Hysterectomy with Preservation of both Ovaries does not Result in Premature Ovarian Failure

Atay, Vedat; Ceyhan, Tevfik; Başer, İskender; Güngör, Şafak; Göktolga, Ümit; Muhçu, Murat

doi:10.1177/147323000703500317

Cited by 11 publications

(7 citation statements)

References 16 publications

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“…We were also able to adjust for a wide range of potential confounders. We excluded women with hysterectomy or hysterectomy with unilateral ovariectomy from the current analysis because not all women with these surgeries have lower estrogen levels than other women with POF [40], [41]. However, some limitations of this study must be considered.…”

Section: Discussionmentioning

confidence: 99%

Impact of Premature Ovarian Failure on Mortality and Morbidity among Chinese Women

Wu¹,

Cai

Kallianpur³

et al. 2014

PLoS ONE

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ObjectiveTo evaluate associations of premature ovarian failure (POF) with mortality and morbidity in Asian populations.MethodsWe identified 1,003 cases of POF among 36,402 postmenopausal women who participated in the Shanghai Women's Health Study, a population-based cohort study. Cox regression and logistic regression models were applied in data analysis.ResultsAfter adjustment for potential confounding factors, we found that POF increased the risk of total and cancer-specific mortality (HR (95%CIs): 1.29 (1.08–1.54) and 1.38 (1.05–1.81), respectively). POF was also associated with high prevalence of autoimmune disease (OR (95%CI): 1.56 (1.04–2.35)) but decreased incidence of breast cancer (OR (95%CI): 0.59 (0.38–0.91)). Similar results were observed when hormone replacement therapy users were excluded from the analysis. POF is associated with high waist-to-hip ratio.ConclusionsOur results suggest that women with POF experience increased mortality and that these women may benefit from heightened surveillance and appropriate interventions.

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Section: Discussionmentioning

confidence: 99%

Impact of Premature Ovarian Failure on Mortality and Morbidity among Chinese Women

Wu¹,

Cai

Kallianpur³

et al. 2014

PLoS ONE

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“…This also helped in controlling many potential confounders such as socioeconomic, demographic, and lifestyle factors. It was also possible to exclude women who had undergone hysterectomy, since women with this surgery have lower estrogen levels than other women who have attained premature or early menopause naturally 54 . However, the study also comes with drawbacks owing to the nature of the data, which were cross‐sectional, and the limitations of recall bias of the last menstrual cycle.…”

Section: Discussionmentioning

confidence: 99%

“…It was also possible to exclude women who had undergone hysterectomy, since women with this surgery have lower estrogen levels than other women who have attained premature or early menopause naturally. 54 However, the study also comes with drawbacks owing to the nature of the data, which were crosssectional, and the limitations of recall bias of the last menstrual cycle. The possibility of more confounders should not be ignored, but the study controlled for all possibilities to get the best estimates.…”

Section: Discussionmentioning

confidence: 99%

Study on depletion of ovarian function and late‐life chronic diseases in India

Kundu

Acharya

2023

Intl J Gynecology & Obste

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ObjectiveThe current study aims to understand premature and early menopausal age in association with chronic conditions.MethodsThe present cross‐sectional study analyzed nationally representative data from LASI (Longitudinal Aging Study in India) from 2017 to 2018. Bivariate analysis including cross‐tabulation and χ2 tests were performed. Further multiple regression analysis was performed, using the generalized linear model of logit link.ResultsApproximately 2533 (8%) older women reported that they had experienced premature menopause (before age 40), while 3889 (12.4%) reported having early menopause (age 40–44). The likelihood of a woman with premature menopause developing cardiovascular diseases (CVDs) is 15% higher (adjusted odds ratio [AOR], 1.15; P < 0.05) than those who do not experience premature menopause, while women with early menopause have a 13% higher risk (AOR, 1.13; P < 0.05). For women who experienced premature menopause and were also smokers, the probability of developing CVDs was higher. Other chronic diseases such as bone or joint problems, diabetes, and eye vision problems were also shown to be significant health problems among women who had premature ovarian failure.ConclusionOur results show significant association between women with premature or early depletion of ovarian function and chronic health conditions such as cardiovascular diseases, bone or joint problems, vision problems, and neurological or psychiatric disorders at their later life ages. Comprehensive strategies in the form of lifestyle changes may regulate hormonal levels and allow the body to reach menopause at the appropriate age.

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“…Beyond these immediate surgical complications, hysterectomy for uterus donation may also have long-term medical consequences that affect quality-of-life. For example, despite some disagreement in the literature (Atay et al 2007), premenopausal women may be at increased risk for ovarian failure after hysterectomy and may require hormone replacement therapy for early menopause (Ahn et al 2002) (Chan et al 2005) (Moorman et al 2011) (Nahás et al 2003). There may also be some risk of sexual dysfunction after hysterectomy.…”

Section: Living Donationmentioning

confidence: 99%

Uterus Transplantation: The Ethics of Using Deceased Versus Living Donors

Bruno

Arora

2018

The American Journal of Bioethics

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Research teams have made considerable progress in treating absolute uterine factor infertility through uterus transplantation, though studies have differed on the choice of either deceased or living donors. While researchers continue to analyze the medical feasibility of both approaches, little attention has been paid to the ethics of using deceased versus living donors as well as the protections that must be in place for each. Both types of uterus donation also pose unique regulatory challenges, including how to allocate donated organs; whether the donor / donor's family has any rights to the uterus and resulting child; how to manage contact between the donor / donor's family, recipient, and resulting child; and how to track outcomes moving forward.

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Hysterectomy with Preservation of both Ovaries does not Result in Premature Ovarian Failure

Cited by 11 publications

References 16 publications

Impact of Premature Ovarian Failure on Mortality and Morbidity among Chinese Women

Impact of Premature Ovarian Failure on Mortality and Morbidity among Chinese Women

Study on depletion of ovarian function and late‐life chronic diseases in India

Uterus Transplantation: The Ethics of Using Deceased Versus Living Donors

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