Hysteresis heating for the treatment of tumours

Borrelli, N. F.; Luderer, Albert A.; Panzarino, Joseph N.

doi:10.1088/0031-9155/29/5/001

Cited by 39 publications

(18 citation statements)

References 10 publications

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“…The authors heated up various damaged tissue samples with 20-100 nm size particles of -Fe 2 O 3 exposed to a 1.2 MHz magnetic field. Since then the scientists have been developing numerous methods and schemes using different types of magnetic materials, different field strengths and frequencies of encapsulation and delivery of the www.intechopen.com particles (Mosso et al, 1973, Rand et al, 1976, Gordon et al, 1979, Rand et al, 1981, Borrelli et al, 1984, Hase et al, 1990, Suzuki et al, 1990, Chan et al, 1993, Matsuki et al, 1994, Mitsumori et al, 1994, Suzuki et al, 1995, Moroz et al, 2001, Jones et al, 2002. The hyperthermia procedure involves the dispersion of the magnetic particles throughout the target tissue, followed by applying an AC magnetic field with specific parameters (frequency, strength); the magnetization of the particles is continuously reversed, which translates into a conversion from magnetic to thermal energy and causes the heating of particles.…”

Section: Oxidation Stabilitymentioning

confidence: 99%

Tailored and Functionalized Magnetite Particles for Biomedical and Industrial Applications

Durdureanu-Angheluta¹,

Pinteală²,

Simionescu³

2012

Materials Science and Technology

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Section: Oxidation Stabilitymentioning

confidence: 99%

Tailored and Functionalized Magnetite Particles for Biomedical and Industrial Applications

Durdureanu-Angheluta¹,

Pinteală²,

Simionescu³

2012

Materials Science and Technology

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“…The specific energy absorption multiplied by the particle density yields the thermal emission powers in unit volume P 1 and P 2 which allow the efficiency of heating of magnetic particles with different sizes to be compared [3,[30][31][32][33][34]. A comparison demonstrates that the conventional ferromagnetic material requires application of ac magnetic fields with strength of ∼100 kA·m -1 or higher, which is less than the saturation field strength.…”

Section: Mechanisms Of Nanoparticle Heating In a Magnetic Liquidmentioning

confidence: 99%

“…Gilchrist et al [16] placed various specimens of tumor tissue with 20-100 nm γ-Fe 2 O 3 nanoparticles injected into them in an ac magnetic field with a frequency of 1.2 MHz. Then numerous publications followed describing various schemes and using various types of magnetic materials, magnetic field strengths and frequencies, methods of preparation and covering with coatings, and nanoparticle delivery [23,26,30,[38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53]. The procedure involves concentration of magnetic nanoparticles scattered in an organism in a tumor tissue and subsequent application of an ac magnetic field of sufficient strength and frequency to cause nanoparticle heating.…”

Section: Application Of Magnetic Hyperthermia In Oncologymentioning

confidence: 99%

Magnetic induction hyperthermia

Никифоров

2007

Russ Phys J

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A review of physical principles and experimental data on magnetic hyperthermia are presented. The main principles of magnetic hyperthermia are considered. Results of its application in the therapy of oncology diseases are presented. PHYSICAL PRINCIPLES OF HYPERTHERMIATwo components of ac electromagnetic fields E and H can cause heating of tissues. Based on the Maxwell equations and thermodynamic relations, not only the electrocaloric effect, namely, the heat absorption in substance caused by the electric field component E [6], but also the magnetocaloric effect caused by variations in H can be calculated. These effects are mainly determined by the dielectric (ε and δε/δТ) and magnetic (μ) properties of substances, respectively. Because magnetism of biological objects is negligibly small, biologically compatible nontoxic magnetic nanoparticles (based on magnetite and so on) are used to strengthen the influence of an external magnetic field.Thermodynamic relations for a magnet in a magnetic field are similar to those for a dielectric in an electric field [6]. However, an essential difference is that the magnetic field, unlike the electric field, does no work on charges moving in it, because the Lorentz force is perpendicular to the velocity vector of the moving charge. To calculate a change in the energy of the medium when the magnetic field is switched on, electric fields induced by magnetic field variations should be considered. In their turn, high-frequency electromagnetic fields cause heating due to the electric field component. At low frequencies, this effect is insignificant. At the same time, the role of the magnetic field component in magnet heating is significant only at low frequencies [6]. Therefore, inclusion of electromagnetic induction hyperthermia in a separate class of high-frequency phenomena [1], on the one hand, and of magnetic hyperthermia as a low-frequency influence, on the other hand, though relative, is justified.Low-frequency (less than 100 kHz) electromagnetic fields can cause heating of magnetic nanoparticles at the expense of the magnetocaloric effect [7], magnetic reversal in the presence of a hysteresis loop, and magnetic crystal anisotropy of superparamagnetic particles. Physics of the magnetocaloric effect of this phenomenon is the following: elementary magnetic moments are directed chaotically without magnetic field, and hence the magnetic contribution to the entropy is significant. As the magnetic field increases, the magnetic moments are ordered along the field. As a result, the magnetic entropy component S M decreases. Because the magnetization process is close to adiabatic one, the total entropy S does not change, but the entropy component caused by thermal motion increases. Thus, the ferromagnet temperature increases with the magnetic field. Quantitatively, the temperature change is calculated from the formula From the above formula it follows that the temperature can raise when the magnetic moment М S changes with temperature, since the heat capacity C is always positive. The ...

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“…If this condition is satis®ed then only tissue containing magnetic particles is heated. A number of authors over the years have described various schemes whereby magnetically induced heating of small particles might be used to heat cancers [8][9][10][11][12][13][14] . However, only relatively few have examined the potential therapeutic bene®ts of heating arterially embolized magnetic particles speci®cally to treat liver cancer 15;16 .…”

Section: Introductionmentioning

confidence: 99%

Treatment of experimental rabbit liver tumours by selectively targeted hyperthermia

Jones

Winter

Gray

2002

International Journal of Hyperthermia

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Experimental rabbit liver tumours were preferentially heated to therapeutic temperatures without compromising the surrounding normal hepatic parenchyma. This was achieved by the use of hepatic arterially infused ferromagnetic microspheres that heat as a result of magnetic hysteresis loss when exposed to an alternating magnetic field. Treatment sessions involving a single 20-min exposure to the alternating field resulted in total suppression of tumour growth at 14 days compared to controls, in which tumour sizes increased dramatically over the same period. Histopathological examination of treated tumour sections showed total tumour destruction in some cases. Separate animal groups used to control for the effects of the embolized microspheres alone and for the effect of the applied magnetic field yielded similar tumour growth responses to a control group with no intervention whatsoever. The achievement of positive temperature differentials between tumour and normal liver and the consequent therapeutic responses encourages further development of this technology for the treatment of liver cancer in humans.

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Hysteresis heating for the treatment of tumours

Cited by 39 publications

References 10 publications

Tailored and Functionalized Magnetite Particles for Biomedical and Industrial Applications

Tailored and Functionalized Magnetite Particles for Biomedical and Industrial Applications

Magnetic induction hyperthermia

Treatment of experimental rabbit liver tumours by selectively targeted hyperthermia

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