I-123 labeled hexadecenoic acid in comparison with Thallium-201 for myocardial imaging in coronary heart disease

Wall, Ernst E. van der; Heidendal, G. A. K.; Hollander, W. den; Westera, G.; Roos, J. P.

doi:10.1007/bf00261781

Cited by 82 publications

(16 citation statements)

References 12 publications

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“…A few arguments favour this concept: in ischaemic myocardium the rate of elimination is delayed when compared with normal myocardium' 4 '. Simultaneous administration with glucose-insuline also decreases the rate of elimination' 3 ', demonstrating the effect of substrate availability in myocardial metabolism. Other data, however, suggest that the elimination rate is not closely related to fatty acid metabolism but merely related to washout of the radiolabel, being split off during betaoxidation 16 ' of the carbon chain.…”

Section: Introductionmentioning

confidence: 93%

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Kinetics of Radioiodinated Heptadecanoic Acid and Metabolites in the Normal and Ischaemic Canine Heart

Visser¹,

Eenige²,

Westera³

et al. 1985

European Heart Journal

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Section: Introductionmentioning

confidence: 93%

“…One of these fatty acids is heptadecanoic acid labelled with radioiodine in the omega position (I-HDA). With this agent, scintigraphic images can be obtained, clearly distinguishing between normal and ischaemic or infarcted myocardium"" 3 '.…”

Section: Introductionmentioning

confidence: 99%

Kinetics of Radioiodinated Heptadecanoic Acid and Metabolites in the Normal and Ischaemic Canine Heart

Visser¹,

Eenige²,

Westera³

et al. 1985

European Heart Journal

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confidence: 99%

Non-significant left main disease; truly non-significant?

Wall

Schuijf

Jukema

et al. 2009

Int J Cardiovasc Imaging

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Amongst the advanced cardiac imaging modalities, multislice computed tomography (MSCT) coronary angiography is emerging as a reliable non-invasive method for the assessment of coronary artery disease (CAD), coronary anatomy and cardiac function [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. Improvements in computed tomography technology hold the promise of replacing the standard invasive procedure of conventional coronary angiography in selected patient groups. Multiple studies involving over several thousands of patients have established that MSCT angiography is highly accurate for delineation of the presence and severity of coronary atherosclerosis [18][19][20][21][22][23]. The technique provides independent prognostic information over baseline clinical risk factors in patients with known and suspected CAD [24]. MSCT may also reveal the total plaque burden, i.e., both calcified and non-calcified components, for individual patients with coronary atherosclerosis [25][26][27][28][29][30][31][32]. This holds in particular for detecting patients with left main disease as this disease is associated with a poor prognosis. Timely detection of atherosclerosis of the left main stem is crucial as it may determine future interventional therapy. The standard of care for left main coronary artery disease is coronary artery bypass surgery (CABG), but technical advances in percutaneous coronary intervention (PCI) and stenting technology have emboldened the interventional cardiology community to test the feasibility of and document the procedural results for stenting the left main coronary artery [33][34][35][36]. MSCT may therefore play an important role for guiding interventional therapy by early detection and establishing the severity and extent of coronary atherosclerosis of the left main coronary artery.Rodriquez-Granillo et al.[34] explored the differences in plaque burden at different segments of the left main bifurcation and its relationship with the bifurcation angle using high-resolution MSCT. A total of 50 patients were evaluated using a 40-row MSCT scanner. The localization, severity and distribution of plaques within the left main bifurcation were determined. Seventeen (34%) patients presented wall irregularities in the left main stem and in the ostial left circumflex coronary artery, whereas the ostial left descending coronary artery was affected in 32 (64%) patients. More than 90% of plaques were located opposite to the flow divider. Of the 18 patients with a normal ostial left anterior descending coronary artery, 13 (72%) had a bifurcation angle \88.5°, whereas the 63% of the patients with any disease of left anterior descending coronary artery had an angle C88.5°(P = 0.018). At the left main bifurcation, atherosclerotic plaques were commonly eccentric and located opposite to the flow divider. A Editorial comment to the article of Gemici et al.

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“…Noninvasive techniques to detect vulnerable atherosclerotic plaque are critically needed. In recent years, radionuclide imaging [3][4][5][6], magnetic resonance imaging (MRI) [7][8][9][10][11][12][13], and computed tomography (CT) have been put forward as the most relevant imaging modalities to identify atherosclerotic vascular disease and the vulnerable plaque [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. Positron emission tomography with fluorodeoxyglucose (FDG-PET) has become one of the advanced imaging approaches for the detection of vulnerable plaques [31].…”

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Atherosclerotic plaque imaging by PET/CT; can inactive, active and mixed plaques be discerned?

Wall

Schuijf

Jukema

et al. 2008

Int J Cardiovasc Imaging

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I-123 labeled hexadecenoic acid in comparison with Thallium-201 for myocardial imaging in coronary heart disease

Cited by 82 publications

References 12 publications

Kinetics of Radioiodinated Heptadecanoic Acid and Metabolites in the Normal and Ischaemic Canine Heart

Kinetics of Radioiodinated Heptadecanoic Acid and Metabolites in the Normal and Ischaemic Canine Heart

Non-significant left main disease; truly non-significant?

Atherosclerotic plaque imaging by PET/CT; can inactive, active and mixed plaques be discerned?

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