I-18 Nanomedicine and Osteoarthritis:what Can We Expect for the Future?

Yudoh, Kazuo; Karasawa, Ryo; Masuko, K.; Shishido, Kanji; Takeuchi, M.; Yamana, Satoshi; Aoshima, H.; Kato, Toyoaki

doi:10.1016/s1063-4584(10)60023-4

Cited by 5 publications

(6 citation statements)

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“…Recent studies have shown that in degenerated articular cartilage, there is significant accumulation of ROS and chondrocyte aging. Studies have also disclosed that there is significant involvement of 8-oxyguanine (oxidative form of guanine) accumulation and impairment of mitochondrial DNA repair enzymes in the pathogenesis of OA and ROS is the major causative agent of 8-oxoguanine production in both DNA and nucleotide pools [139].…”

Section: Therapeutic Strategiesmentioning

confidence: 99%

[Retracted] Multifunctional Therapeutic Approach of Nanomedicines against Inflammation in Cancer and Aging

Rahman

Islam

Mim

et al. 2022

Journal of Nanomaterials

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Cancer is a fatal disorder that affects people across the globe, yet existing therapeutics are ineffective. The development of submicrometer transport for optimizing the biodistribution of systemically provided medications is the focus of nanomedicine. Nanoparticle- (NP-) based treatments may enable the development of novel therapeutic approaches to combat this deadly disorder. In multifunctional, multimodal imaging, and drug delivery carriers, NPs generally play a major role. They have emerged as potential strategies for the invention of innovative therapeutic procedures in the last decade. The exponential growth of nanotechnologies in recent years has increased public awareness of the application of these innovative therapeutic approaches. Many tumor-targeted nanomedicines have been studied in cancer therapy, and there is clear evidence for a significant improvement in the therapeutic index of antineoplastic drugs. Age-related factors such as metabolic and physiological alterations in old age and inadequate animal models are currently understudied in nanomedicine and pharmacology. This review highlighted the most important targeting approaches, as well as public awareness, therapeutic advancements, and future prospects in age-related metabolic variations, and tumor-targeted nanomedicine studies.

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Section: Therapeutic Strategiesmentioning

confidence: 99%

[Retracted] Multifunctional Therapeutic Approach of Nanomedicines against Inflammation in Cancer and Aging

Rahman

Islam

Mim

et al. 2022

Journal of Nanomaterials

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“…These results suggest that the sugar-pendant fullerenes act as a radicalscavenging antioxidant with the activity similar to the phenolic antioxidants. 186 The potential of a strong free-radical scavenger, water-soluble C 60 fullerene, as a protective agent against synovitis 187 and against osteoclastogenesis and osteoclastic bone destruction 188 in arthritis, both in vitro and in vivo were investigated.…”

Section: Advanced Materialsmentioning

confidence: 99%

Fullerenes

Darwish¹

2010

Annu. Rep. Prog. Chem., Sect. A: Inorg. Chem.

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“…Dellinger et al found that fullerenols inhibit the development of rheumatoid arthritis and decrease bone damage . Yudoh et al confirmed that fullerenols can suppress osteoclast formation and bone destruction in arthritis . Therefore, we speculate that fullerenols may inhibit RB formation by reorganizing B‐actins, which hampers bone resorption of osteoclasts.…”

Section: Introductionmentioning

confidence: 57%

Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca²⁺ Bundles

Chen

Xiu-ling

et al. 2018

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Osteoporosis, a common and serious bone disorder affecting aged people and postmenopausal women, is characterized by osteoclast overactivity. One therapeutic strategy is suppressing the bone resorption function of hyperactive osteoclasts, but there is no effective drug in clinical practice so far. Herein, it is demonstrated that fullerenols suppress the bone resorption of osteoclasts by inhibiting ruffled borders (RBs) formation. The RBs formation, which is supported by well‐aligned actin bundles (B‐actins), is a critical event for osteoclast bone resorption. To facilitate this function, osteoclast RBs dynamics is regulated by variable microenvironments to bundle F‐actins, protrude cell membrane, and so on. B‐actin perturbation by fullerenols is determined here, offering an opportunity to regulate osteoclast function by destroying RBs. In vivo, the therapeutic effect of fullerenols on overactive osteoclasts is confirmed in a mouse model of lipopolysaccharide‐induced bone erosion. Collectively, the findings suggest that fullerenols adhere to F‐actin surfaces and inhibit RBs formation in osteoclasts, mainly through hampering Ca2+ from bundling F‐actins, and this is likely due to the stereo‐hindrance effect caused by adherent fullerenols.

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I-18 Nanomedicine and Osteoarthritis:what Can We Expect for the Future?

Cited by 5 publications

References 0 publications

[Retracted] Multifunctional Therapeutic Approach of Nanomedicines against Inflammation in Cancer and Aging

[Retracted] Multifunctional Therapeutic Approach of Nanomedicines against Inflammation in Cancer and Aging

Fullerenes

Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca²⁺ Bundles

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I-18 Nanomedicine and Osteoarthritis:what Can We Expect for the Future?

Cited by 5 publications

References 0 publications

[Retracted] Multifunctional Therapeutic Approach of Nanomedicines against Inflammation in Cancer and Aging

[Retracted] Multifunctional Therapeutic Approach of Nanomedicines against Inflammation in Cancer and Aging

Fullerenes

Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca2+ Bundles

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Product

Resources

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Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca²⁺ Bundles