<i>ABCB1</i> C3435T Polymorphism and the Risk of Coronary Heart Disease: A Meta-Analysis

Jin, Yinji; Wang, Qi; Wang, Guofeng; Zhang, Xueying; Yan, Bin; Hu, Weina

doi:10.1089/gtmb.2013.0407

Cited by 1 publication

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“…ABCB1’ s promoter region contains multiple transcription factor binding sequences, including specific protein 1, activator protein 1, nuclear factor interleukin (IL) 6, and forehead transcription factor or T cell factor/lymphoid enhancer factor, suggesting the presence of a complex regulatory mechanism [ 18 ]. A previous study has shown that certain specific polymorphisms in the promoter region of ABCB1 may play an important regulatory role in coronary heart disease occurrence and development [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…ABCB1 has been reported to mediate the process of systemic inflammation [ 19 ]. On the one hand, ABCB1 can secrete endogenous inflammatory mediators, such as prostaglandins and leukotrienes.…”

Section: Discussionmentioning

confidence: 99%

“…ABCB1 thus can act as a highly sensitive indicator of inflammation. The increase in serum ABCB1 levels can be related to the future dangers of coronary heart disease [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

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Expression of ATP-binding cassette subfamily B member 1 gene in peripheral blood of patients with acute myocardial infarction

et al. 2022

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This study aimed to determine the amount of expression of the ATP-binding cassette subfamily B member 1 (ABCB1) gene chip as a prospective diagnostic marker for acute myocardial infarction (AMI) in a wide population . In the AMI and control groups, 113 patients with AMI and 83 persons with non-coronary artery disease were selected for peripheral venous leukocyte collection. Western blot and real-time polymerase chain reaction (RT-PCR) were employed to detect relative ABCB1 expression in both groups. The results showed that the ABCB1 transcription and protein levels in the AMI group were higher than in the control. The relative mRNA expression of ABCB1 was 0.26 (0.03–0.79) in the AMI group and 0.13 (0.01–0.52) in the control group (P < 0.05). The expression of the ABCB1 gene at the protein level in the AMI group was 1.65 times that in the control (P < 0.05). Further, the subjects in the AMI group were older (P < 0.001), had lower levels of high-density lipoprotein cholesterol (P = 0.038), and had higher incidence of type II diabetes mellitus (P = 0.003) compared with the control. Logistic regression analysis showed that the expression of ABCB1 in peripheral blood was correlated with the occurrence of AMI (P = 0.003). High ABCB1 expression, type II diabetes, and advanced age were found to serve as potential independent risk factors for AMI, with a 4.88-fold, 2.99-fold, and 2.63-fold increased risk of AMI. Overall, the high expression of ABCB1 in peripheral blood might be related to the occurrence of AMI.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Expression of ATP-binding cassette subfamily B member 1 gene in peripheral blood of patients with acute myocardial infarction

et al. 2022

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ABCB1 C3435T Polymorphism and the Risk of Coronary Heart Disease: A Meta-Analysis

Abstract: The current meta-analysis suggests that ABCB1 C3435T polymorphism may contribute to the risk of CHD, especially for MI and ACS, among Caucasian populations. Thus, detection of ABCB1 C3435T polymorphism may be a promising biomarker for the early detection of CHD.

Cited by 1 publication

References 41 publications

Expression of ATP-binding cassette subfamily B member 1 gene in peripheral blood of patients with acute myocardial infarction

Expression of ATP-binding cassette subfamily B member 1 gene in peripheral blood of patients with acute myocardial infarction

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