Acanthopanax senticosus: Photochemistry and Anticancer Potential

Abstract

Acanthopanax senticosus (previously classified as Eleutherococcus senticosus), commonly known as Ciwujia or Siberian Ginseng, is a traditional Chinese medicine (TCM), widely used for its high medicinal value, such as antifatigue, anti-inflammation, antistress, anti-ulcer and cardiovascular functions, in China, Korea, Japan and Russia. In the past decades, researchers worldwide have conducted systematic investigations on this herb, from chemistry to pharmacology, and a large number of chemical components have been characterized for their significant pharmacological effects. However, reports about the anticancer effects of this plant had been rare until recently, when considerable pharmacological experiments both in vitro and in vivo were conducted to study the anticancer effects of this herb. A. senticosus has been found to have inhibitory effects on malignant tumors, such as those in the lung and liver, suggesting that A. senticosus has potential to be developed as an effective anticancer drug. This paper reviews recent findings on the pharmacological properties of A. senticosus, with a focus on its anticancer effects.

Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

“…Eleutherococcus senticosus ( E. senticosus ) belongs to the family of Araliaceae and is mostly found in China, Japan and Korea [ 269 ]. E. senticosus is used for the treatment of chronic coughing, ischemic heart disease, diabetes, cancer, altitude sickness, neurodegenerative disorders, and chronic fatigue [ 149 , 159 , 269 , 270 ]. Moreover, its leaves are used as food in the form of tea, wine, soups and many others [ 271 ].…”

Improved Resting-State Functional Dynamics in Post-stroke Depressive Patients After Shugan Jieyu Capsule Treatment

“…Shugan Jieyu Capsule (SG) is a Chinese herbal medicine that is primarily made up of Acanthopanax and Hypericum perforatum (Yang, 2015) and has been licensed and widely prescribed for depression in China since 2008 (Sun et al, 2009). Acanthopanax, commonly known as ciwujia or Siberian ginseng, is a traditional Chinese medicine that ameliorates cognitive dysfunction induced by cholinergic blockade (Li et al, 2016). Hypericum perforatum, also called St. John's wort, has been used as an antidepressant agent and a cognitive enhancer in rodents (Avila et al, 2018).…”

Discrimination and quality evaluation of fifteen components in Stauntonia hexaphylla leaves from different harvest time by HPLC–PDA–ESI–MS/MS and ELSD coupled with multivariate statistical analysis and anti-inflammatory activity evaluation

“…Moreover, in the MS and MS/MS spectra in positive mode, aglycone ions were observed at m/z 439.4 and 457.2, which corresponded to oleanolic acid. According to our previous experimental data and previous literature, peak 5 was tentatively identified as anhuienside C [11,12]. Peaks 13,14, and 15 are attributed to the same aglycone ions as that of peak 5; they were tentatively assigned as araliasaponin II, hexaphyloside A, and ciwujianoside C3, respectively, by comparison with known compounds isolated from S. hexaphylla and their families [13][14][15][16][17] Figure S4).…”