“…The cell envelope of M. tuberculosis, a Gram-positive bacterium with a G + C-rich genome, contains an additional layer beyond the peptidoglycan that is exceptionally rich in unusual lipids, glycoli-pids and polysaccharides 4,5 . Novel biosynthetic pathways generate cell-wall components such as mycolic acids, mycocerosic acid, phenolthiocerol, lipoarabinomannan and arabinogalactan, and several of these may contribute to mycobacterial longevity, trigger inflammatory host reactions and act in pathogenesis.…”