Achatina fulicaHaemocyanin-Derived Peptides as Novel Antimicrobial Agents
Andrés Pereira,
Libardo Suarez,
Tanya Roman
et al.
Abstract:Anteriorly we found Haemocyanin-derived peptides in semi-purified fractions of mucus secretion ofAchatina fulicathat showed an inhibitory effect onS. aureusstrains. Here, we appliedin silicorational design strategy to obtain new potential Antimicrobial Peptides (AMPs) fromA. fulicahaemocyanin-derived peptides (AfH). Designed peptides were chemically synthetized using the Fmoc strategy and antimicrobial activity againstE. coliandS. aureusstrains was investigated using the broth microdilution method. Cytotoxic a… Show more
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