<i>Acinetobacter baumannii</i>
            : Emergence of a Successful Pathogen

Peleg, Anton Y.; Seifert, Harald; Paterson, David L.

doi:10.1128/cmr.00058-07

Cited by 2,959 publications

(3,233 citation statements)

References 599 publications

(829 reference statements)

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“…OXA-type carbapenemases have predominated in A. baumannii, especially worldwide outbreaks of OXA-23 [1]. Recently the GES-1-like carbapenemases have also been reported for A. baumannii [9,14,23,24,25].…”

Section: Discussionmentioning

confidence: 99%

“…[CHDLs]), the latter being the most disseminated worldwide [1,2]. As elsewhere [4,5,6], occurrence of carbapenem resistance in A. baumannii in North Africa has been mainly attributed to the production of CHDLs, with OXA-23 and OXA-58-like enzymes being the most prevalent [3,7,8].…”

Section: Ndm) or To Class D (Carbapenem-hydrolyzing Class D B-lactamasesmentioning

confidence: 99%

“…In addition, community-acquired A. baumannii infections are now reported [1]. Through the acquisition of antibiotic resistance genes by lateral gene transfer, A. baumannii has an extraordinary ability to become resistant to almost all antibiotics, leading to multidrug-resistant isolates [2,3].…”

Section: Introductionmentioning

confidence: 99%

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Multidrug-resistant Acinetobacter baumannii strains carrying the blaOxA-23 and the blaGES-11 genes in a neonatology center in Tunisia

Charfi

Mansour²,

Khalifa³

et al. 2014

Microbial Pathogenesis

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Multidrug-resistant and difficult-to-treat Acinetobacter baumannii may be responsible for nosocomial infections. The production of carbapenem-hydrolyzing class D b-lactamases (CHDLs) and extendedspectrum b-lactamase (ESBLs) of the GES type possessing a carbapenemase activity has been increasingly reported worldwide in A. baumannii. The aim of this study was to analyze the resistance mechanisms of two carbapenem resistant A. baumannii clinical isolates recovered in a neonatology center in the center-east of Tunisia.Two carbapenem resistant A. baumannii isolates were recovered. The first isolate co-harbored the bla GES-11 ESBL gene and the bla OxA-23 CHDL gene. Analyses of the genetic location indicated that the bla GES-11 gene was plasmid located (Gr6). However, the bla OxA-23 gene was located on the chromosome. The second strain had only the bla OxA-23 CHDL gene, which was plasmid located.This study showed the first description of the GES-type b-lactamase in A. baumannii in Tunisia.

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Section: Discussionmentioning

confidence: 99%

Section: Ndm) or To Class D (Carbapenem-hydrolyzing Class D B-lactamasesmentioning

confidence: 99%

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Multidrug-resistant Acinetobacter baumannii strains carrying the blaOxA-23 and the blaGES-11 genes in a neonatology center in Tunisia

Charfi

Mansour²,

Khalifa³

et al. 2014

Microbial Pathogenesis

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“…External quality control involved participation in ring tests. We defined MDR as resistance to three or more classes of recommended drugs [2,11]. If two antibiotics from one class were tested, both needed to be resistant in order to meet the definition.…”

Section: Antimicrobial Susceptibility Testing and Definition Of Mdrmentioning

confidence: 99%

Increasing Occurrence of Multidrug-Resistance in Acinetobacter baumannii Isolates From Four German University Hospitals, 2002–2006

et al. 2010

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Background: Acinetobacter baumannii can cause severe infections, mainly in critically ill inpatients. Treatment is complicated by multidrug-resistance (MDR). In Germany, to date, little is known on the extent of MDR in A. baumannii isolated from inpatients in German hospitals (OR 1.8,). The lowest in vitro antibiotic resistance was found in meropenem, imipenem and ampicillin/sulbactam, with 33, 37 and 39% for multidrugresistant and 0.4, 1 and 3% in non-multidrug-resistant A. baumannii

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“…Acinetobacter baumannii infection may result in pneumonia, bloodstream infection, urinary tract infection, meningitis and wound infection as well as other manifestations of infection [1].…”

Section: Introductionmentioning

confidence: 99%

Outbreaks of multidrug-resistant Acinetobacter baumannii strains in a Kenyan teaching hospital

Huber

Sartor

McOdimba

et al. 2014

Journal of Global Antimicrobial Resistance

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Acinetobacter baumannii is a serious nosocomial pathogen with a high propensity to cause outbreaks. Whilst outbreaks of A. baumannii have been reported in many regions worldwide, few data are available from East Africa. In this study, 25 A.baumannii isolates derived from a single institution located in Nairobi, Kenya, between September 2010 and September 2011 were examined. Antimicrobial susceptibility testing was performed by the disk diffusion method and the relatedness among the isolates was examined by pulsed-field gel electrophoresis, repetitive sequence-based PCR (rep-PCR) and multilocus sequence typing. The examined isolates clustered into three distinct groups. The most prevalent sequence type (ST) was ST110 (17 isolates), followed by ST92 (5 isolates) and ST109 (3 isolates). All isolates exhibited resistance to cefepime, ceftazidime, ticarcillin/clavulanic acid, cefotaxime/clavulanic acid, piperacillin/tazobactam, cefoxitin, ciprofloxacin, gentamicin, nitrofurantoin, fosfomycin trometamol, trimethoprim/sulfamethoxazole, amikacin, meropenem and imipenem, with the exception of four isolates. Two isolates belonging to ST92 and two isolates belonging to ST109 were susceptible to amikacin; one of these amikacin-susceptible ST109 isolates was also susceptible to meropenem and imipenem. All isolates were positive for OXA 51-like and all carbapenem-resistant isolates were OXA-23 positive.

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Acinetobacter baumannii : Emergence of a Successful Pathogen

Cited by 2,959 publications

References 599 publications

Multidrug-resistant Acinetobacter baumannii strains carrying the blaOxA-23 and the blaGES-11 genes in a neonatology center in Tunisia

Multidrug-resistant Acinetobacter baumannii strains carrying the blaOxA-23 and the blaGES-11 genes in a neonatology center in Tunisia

Increasing Occurrence of Multidrug-Resistance in Acinetobacter baumannii Isolates From Four German University Hospitals, 2002–2006

Outbreaks of multidrug-resistant Acinetobacter baumannii strains in a Kenyan teaching hospital

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