“…Studies have shown that the diterpenoid alkaloids from A. coreanum had anti-arrhythmic effects on cardiac sodium current [ 30 ], the total alkaloids from A. coreanum were correlation with atrial fibrillation [ 31 ], Guanfu base A and Guanfu base G had effect on HERG K + channel [ 32 ]. As a commonly used traditional Chinese medicine in clinical practice, A. coreanum also has a long history and good clinical efficacy in treating CIS [ 33 ]. However, there is a lack of research on the relationship between the components of A. coreanum and efficacy in treating CIS.…”