<i>ACTINOBACILLUS MURIS</i> SP. NOV. ISOLATED FROM MICE

Bisgaard, Magne

doi:10.1111/j.1699-0463.1986.tb03013.x

Cited by 20 publications

(12 citation statements)

References 15 publications

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“…Phenotypic characters shared by all strains investigated (some included for genus-level separation; Table 1) were in accordance with the description of [A. ] muris (Bisgaard, 1986) except for variable reactions in acid formation from (2)-Dmannitol as well as variable reactions for indole production, urease and hydrolysis of aesculin. The a-glucosidase test (PNPG; 4-nitrophenyl a-D-glucopyranoside) was found to be positive.…”

supporting

confidence: 62%

“…[Actinobacillus] muris was originally described based on 19 strains isolated from the oral cavity of healthy mice, with the provisional designation Bisgaard taxon 12 and the selection of a previously described reference strain (Ackerman80-443D T 5NCTC 12432 T ) as the type strain (Bisgaard, 1986) (Table S1, available in the online Supplementary Material). DNA reassociation studies showed that [A. ]…”

mentioning

confidence: 99%

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Reclassification of Actinobacillus muris as Muribacter muris gen. nov., comb. nov.

Nicklas

Bisgaard²,

Aalbæk

et al. 2015

International Journal of Systematic and Evolutionary Microbiology

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Reclassification of Actinobacillus muris as Muribacter muris gen. nov., comb. nov. To reinvestigate the taxonomy of [Actinobacillus ] muris, 474 strains, mainly from mice and rats, were characterized by phenotype and 130 strains selected for genotypic characterization by 16S rRNA and partial rpoB gene sequencing. The type strain was further investigated by wholegenome sequencing. Phylogenetic analysis of the DNA sequences showed one monophyletic group with intragroup similarities of 96.7 and 97.2 % for the 16S rRNA and rpoB genes, respectively. The highest 16S rRNA gene sequence similarity to a taxon with a validly published name outside the group was 95.9 %, to the type strain of [Pasteurella] pneumotropica. The closest related taxon based on rpoB sequence comparison was 'Haemophilus influenzaemurium', with 88.4 % similarity. A new genus and a new combination, Muribacter muris gen. nov., comb. nov., are proposed based on a distinct phylogenetic position based on 16S rRNA and rpoB gene sequence comparisons, with major divergence from the existing genera of the family Pasteurellaceae. The new genus has the characteristics of [A.] muris with the emendation that acid formation from (2)-D-mannitol and hydrolysis of aesculin are variable, while the a-glucosidase test is positive. There is no requirement for exogenously supplied NAD (V factor) for the majority of strains investigated; however, one strain was found to require NAD. The major fatty acids of the type strain of Muribacter muris were C 14 : 0 , C 14 : 0 3-OH/iso-C 16 : 1 I, C 16 : 1 v7c and C 16 : 0 , which is in line with most genera of the Pasteurellaceae. The type strain of Muribacter muris is CCUG 16938 T (5NCTC 12432 T 5ATCC 49577 T ).

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supporting

confidence: 62%

mentioning

confidence: 99%

Reclassification of Actinobacillus muris as Muribacter muris gen. nov., comb. nov.

Nicklas

Bisgaard²,

Aalbæk

et al. 2015

International Journal of Systematic and Evolutionary Microbiology

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“…For each colony morphotype, the highest scoring aligned sequence from the RDP database is associated with mice. Actinobacillus muris [43], L. murinus [44] and Staphylococcus saprophyticus [45] are murine commensal oral bacteria. Corynebacteria are commensals of the skin and mucous membranes of humans and animals, with C. mastitidis recently identified as an opportunistic infectious resident of the epidermis of laboratory mice [46].…”

Section: Discussionmentioning

confidence: 99%

Oral colonization by Streptococcus mutans and caries development is reduced upon deletion of carbonic anhydrase VI expression in saliva

Culp

Robinson

Parkkila

et al. 2011

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Carbonic anhydrase VI (CA VI), encoded by type A transcripts of the gene Car6, is a secretory product of salivary glands and is found in the enamel pellicle. Because higher caries prevalence is associated with lower salivary concentrations of CA VI in humans, we tested whether CA VI protects enamel surfaces from caries induced by Streptococcus mutans, using Car6−/− mice, in which salivary CA VI expression is absent. We detected aberrant Car6 type A transcripts in Car6−/− mice, likely targets for nonsense-mediated mRNA decay. Expression of the intracellular stress-induced isoform of CA VI encoded by type B transcripts was restricted to parotid and submandibular glands of wild type mice. The salivary function of Car6−/− mice was normal as assessed by the histology and protein/glycoprotein profiles of glands, salivary flow rates and protein/glycoprotein compositions of saliva. Surprisingly, total smooth surface caries and sulcal caries in Car6−/− mice were more than 6-fold and 2-fold lower than in wild type mice after infection with S. mutans strain UA159. Recoveries of S. mutans and total microbiota from molars were also lower in Car6−/− mice. To explore possible mechanisms for increased caries susceptibility, we found no differences in S. mutans adherence to salivary pellicles, in vitro. Interestingly, higher levels of Lactobacillus murinus and an unidentified Streptococcus species were cultivated from the oral microbiota of Car6−/− mice. Collective results suggest salivary CA VI may promote caries by modulating the oral microbiota to favor S. mutans colonization and/or by the enzymatic production of acid within plaque.

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“…16 S rRNA gene sequences from white colonies of cocci most closely align to uncultured bacteria assigned to the genus Streptococcus (designated S. unassigned). Five of the six species identified were shown previously to colonize mice (42)(43)(44)(45)(46), whereas Streptococcus thoraltensis has been found in rabbits (47). For comparisons with human oral microbiota, each consensus sequence was also aligned to the annotated Human Oral Microbiome Database 16 S rRNA reference sequences from the human oral microbiome.…”

Section: Caries Development and Recovery Of Bacteria-muc19mentioning

confidence: 99%

Salivary Mucin 19 Glycoproteins

Culp¹,

Robinson²,

Cash³

et al. 2015

Journal of Biological Chemistry

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Background:We investigated murine salivary Muc19, in vivo and in vitro, to protect against dental infections. Results: Muc19 attenuates dental infections by Streptococcus mutans and promotes its aggregation. Evidence for human salivary MUC19 is presented. Conclusion: Murine Muc19 helps limit colonization via clearance of S. mutans. Significance: A role for Muc19 in clearance expands upon acknowledged innate immune functions of salivary gel-forming mucins.

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ACTINOBACILLUS MURIS SP. NOV. ISOLATED FROM MICE

Cited by 20 publications

References 15 publications

Reclassification of Actinobacillus muris as Muribacter muris gen. nov., comb. nov.

Reclassification of Actinobacillus muris as Muribacter muris gen. nov., comb. nov.

Oral colonization by Streptococcus mutans and caries development is reduced upon deletion of carbonic anhydrase VI expression in saliva

Salivary Mucin 19 Glycoproteins

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