ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney Disease

Abstract

Background. This meta-analysis was performed to obtain a more comprehensive estimation of the role of the single nucleotide polymorphism (SNP) rs2241766 in the ADIPOQ gene in the occurrence of diabetic kidney disease (DKD). Methods. Relevant studies were identified from digital databases such as Embase, PubMed, Medline, Cochrane Library, Google Scholar, WanFang, and Chinese National Knowledge Infrastructure (CNKI). Odds ratios (ORs) with their corresponding 95% confidence intervals (95% CIs) were pooled by means of fixed- or random-effects models. Interstudy heterogeneity was examined using the Q test and I2 statistic, and sensitivity analysis was implemented to test the statistical stability of the overall estimates. Begg’s funnel plot and Egger’s test were applied to inspect potential publication bias among the included studies. Results. The overall ORs reflected a positive correlation between the ADIPOQ rs2241766 polymorphism and susceptibility to DKD in the GG vs. TT and GG vs. TT+TG comparisons (OR=1.51, 95%CI=1.16−1.95; OR=1.43, 95%CI=1.11−1.85). After stratification analyses by ethnicity and disease type, a similar trend was also revealed in the Caucasian and African subgroups as well as in the type 2 diabetes mellitus (T2DM) subgroup. Conclusion. The ADIPOQ rs2241766 polymorphism may be associated with an increased risk of DKD, especially in Caucasian and African populations as well as in T2DM patients.

Urinary sediment microRNAs can be used as potential noninvasive biomarkers for diagnosis, reflecting the severity and prognosis of diabetic nephropathy

“…The incidence of diabetes mellitus (DM) has gradually increased with the development of a social economy, and the number of patients with diabetes is expected to exceed 693 million by 2045 [ 1 ]. Approximately 40% of diabetic patients are prone to the development of diabetic nephropathy (DN) [ 2 – 4 ]. DN is one of the most common microvascular complications of diabetes and is considered the most common cause of end-stage renal disease (ESRD) [ 5 , 6 ].…”

Susceptibility of ApoB and PCSK9 Genetic Polymorphisms to Diabetic Kidney Disease Among Chinese Diabetic Patients

“…DKD is a polygenic disease ( 18 ). A long list of genes have been identified to play a contributory role in the pathogenesis of DKD, such as ADIPOQ gene ( 19 ) and IL-6 gene ( 20 ). However, the results are not often reproducible at a population level.…”

The role of adiponectin and its receptor in patients with idiopathic membranous nephropathy complicated with hyperuricemia

“…UA has recently been certified as a risk factor for the development, prognosis, and progression of IMN [5,6,7,9,21,22], which also leads to kidney inflammation in a lens-dependent and -independent manner [23]. The research showed that UA may firstly activate the NLRP3 inflammatory pathway.…”