<i>Akkermansia muciniphila</i>attenuated lipopolysaccharide-induced acute lung injury by modulating the gut microbiota and SCFAs in mice

Shen, Jian; Wang, Shuting; Xia, He; Han, Shengyi; Wang, Qiangqiang; Wu, Zhengjie; Zhuge, Aoxiang; Li, Shengjie; Chen, Hui; Lv, Longxian; Chen, Yanfei; Li, Lanjuan

doi:10.1039/d3fo04051h

Cited by 14 publications

(4 citation statements)

References 69 publications

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“…However, the MPTP + Akk treatment significantly decreased the C S /C F of isobutyric acid and isovaleric acid compared to the MPTP + Vehicle group. Taken together, these results suggest that Akk treatment led to a reduction in intestinal permeability in PD mice to some extent, which is consistent with previous research suggesting that Akk improves intestinal barrier function [9,11,21].…”

Section: Akk Treatment Regulated Production Of Serum and Fecal Scfas ...supporting

confidence: 92%

“…In the present study, we also investigated the role of Akk in neurogenesis. As for the mechanisms of Akk, it has been reported that it may exert beneficial effects on the host through its major metabolites, which are short-chain fatty acids (SCFAs) [ 20 , 21 ]. Another study demonstrated that decreased SCFAs in feces and increased SCFAs in plasma in PD patients correlated with specific alterations in the gut microbiota and the extent of PD clinical severity [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Akkermansia muciniphila Is Beneficial to a Mouse Model of Parkinson’s Disease, via Alleviated Neuroinflammation and Promoted Neurogenesis, with Involvement of SCFAs

Qiao,

Huang,

Zhou

et al. 2024

Brain Sciences

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Increasing evidence suggests that the gut microbiota may represent potential strategies for Parkinson’s disease (PD) treatment. Our previous research revealed a decreased abundance of Akkermansia muciniphila (Akk) in PD mice; however, whether Akk is beneficial to PD is unknown. To answer this question, the mice received MPTP intraperitoneally to construct a subacute model of PD and were then supplemented with Akk orally for 21 consecutive days. Motor function, dopaminergic neurons, neuroinflammation, and neurogenesis were examined. In addition, intestinal inflammation, and serum and fecal short-chain fatty acids (SCFAs) analyses, were assessed. We found that Akk treatment effectively inhibited the reduction of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and partially improved the motor function in PD mice. Additionally, Akk markedly alleviated neuroinflammation in the striatum and hippocampus and promoted hippocampal neurogenesis. It also decreased the level of colon inflammation. Furthermore, these aforementioned changes are mainly accompanied by alterations in serum and fecal isovaleric acid levels, and lower intestinal permeability. Our research strongly suggests that Akk is a potential neuroprotective agent for PD therapy.

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Section: Akk Treatment Regulated Production Of Serum and Fecal Scfas ...supporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Akkermansia muciniphila Is Beneficial to a Mouse Model of Parkinson’s Disease, via Alleviated Neuroinflammation and Promoted Neurogenesis, with Involvement of SCFAs

Qiao,

Huang,

Zhou

et al. 2024

Brain Sciences

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“…Akkermansia muciniphila is a promising candidate probiotic that has beneficial effects on host immunologic and metabolic functions [ 48 ]. The causal evidence of its anti-inflammatory property via reducing the levels of inflammatory cytokines has been reported in a variety of mouse model studies [ 49 , 50 ]. On the other hand, the close intra-system interactions indicated that our findings were reliable, such as that slaughter weight was intimately associated with carcass weight and the different stress status indicators were positively or negatively correlated with production performance.…”

Section: Discussionmentioning

confidence: 99%

Seasonal Variations in Production Performance, Health Status, and Gut Microbiota of Meat Rabbit Reared in Semi-Confined Conditions

Ye,

Ding,

Pang

et al. 2023

Animals

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In this study, we investigated the variations in production performance, health status, and gut microbiota of meat rabbits raised in the semi-confined barn during summer and winter. Compared to summer, rabbits reared in winter possessed significantly higher slaughter weight and carcass weight. Rabbits fed in the summer were more vulnerable to different stressors, which led to increased protein levels of HSP90, IL-1α, IL-1β, IL-2, and concentrations of MDA, but declined GSH and SOD activities. Additionally, significant differences in gut microbial communities were observed. Compared to the winter, rabbits fed in the summer had significantly lower and higher alpha and beta diversity. Both Firmicutes and Verrucomicrobiota were the dominant phyla, and they accounted for greater proportions in the winter than in the summer. At lower microbial taxa levels, several seasonal differentially enriched microbes were identified, such as Akkermansia muciniphila, the Oscillospiraceae NK4A214 group, the Christensenellaceae R-7 group, Alistipes, and Muribaculaceae. Functional capacities linked to microbial proliferation, nutrient metabolism, and environmental adaptive responses exhibited significantly different abundances between summer and winter. Moreover, strong interactions among different indicators were presented. Based on our findings, we not only proposed several potential strategies to ameliorate the undesirable effects of seasonal changes on the productivity and health of meat rabbits but also underscored the directions for future mechanistic studies of adaptation physiology.

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“…A. muciniphila has the function of reducing FFA levels by alleviating obesity. In addition, A. muciniphila improved the structure and composition of the intestinal microbiota and promoted the production of short-chain fatty acid ( 88 ). Acetic acid, propionic acid and butyric acid targeted G protein-coupled receptors 41 and 43 on the surface of intestinal L cells, which activated downstream molecular signaling and ultimately promoted the secretion of glucagon-like peptide-1(GLP-1) ( 89 ).…”

Section: The Utility Of a Muciniphila In Metabolic...mentioning

confidence: 99%

Akkermansia muciniphila: a potential candidate for ameliorating metabolic diseases

Niu,

Zhou,

Zogona

et al. 2024

Front. Immunol.

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Metabolic diseases are comprehensive disease based on obesity. Numerous cumulative studies have shown a certain correlation between the fluctuating abundance of Akkermansia muciniphila and the occurrence of metabolic diseases. A. muciniphila, a potential probiotic candidate colonized in the human intestinal mucus layer, and its derivatives have various physiological functions, including treating metabolic disorders and maintaining human health. This review systematically explicates the abundance change rules of A. muciniphila in metabolic diseases. It also details the high efficacy and specific molecules mechanism of A. muciniphila and its derivatives in treating obesity, type 2 diabetes mellitus, cardiovascular disease, and non-alcoholic fatty liver disease.

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Akkermansia muciniphilaattenuated lipopolysaccharide-induced acute lung injury by modulating the gut microbiota and SCFAs in mice

Abstract: Akkermansia muciniphila attenuated lipopolysaccharide-induced acute lung injury by modulating the gut microbiota and SCFAs in mice.

Cited by 14 publications

References 69 publications

Akkermansia muciniphila Is Beneficial to a Mouse Model of Parkinson’s Disease, via Alleviated Neuroinflammation and Promoted Neurogenesis, with Involvement of SCFAs

Akkermansia muciniphila Is Beneficial to a Mouse Model of Parkinson’s Disease, via Alleviated Neuroinflammation and Promoted Neurogenesis, with Involvement of SCFAs

Seasonal Variations in Production Performance, Health Status, and Gut Microbiota of Meat Rabbit Reared in Semi-Confined Conditions

Akkermansia muciniphila: a potential candidate for ameliorating metabolic diseases

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