2023
DOI: 10.15252/embr.202357485
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Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL‐1R/TLR signals

Yuxin Wang,
Tatsuya Morishima,
Maiko Sezaki
et al.

Abstract: Bacterial infections can activate and mobilize hematopoietic stem and progenitor cells (HSPCs) from the bone marrow (BM) to the spleen, a process termed extramedullary hematopoiesis (EMH). Recent studies suggest that commensal bacteria regulate not only the host immune system but also hematopoietic homeostasis. However, the impact of gut microbes on hematopoietic pathology remains unclear. Here, we find that systemic single injections of Akkermansia muciniphila (A. m.), a mucin‐degrading bacterium, rapidly act… Show more

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