<i>Akt-interacting proteins: attractive opposites</i>. Focus on “Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways”

Franke, Thomas

doi:10.1152/ajpcell.00451.2007

Cited by 20 publications

(34 citation statements)

References 27 publications

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“…This shared property suggests that their interaction with Akt isoforms affects enzymatic activity, access to upstream regulatory components, or intracellular localization and distribution. Thus, consequences of binding for Akt function are diverse and may differ depending on cell types and experimental conditions (for review, see Franke, 2007).…”

Section: Mouse Models Of Altered Akt Functionmentioning

confidence: 99%

PI3K/Akt: getting it right matters

2008

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Section: Mouse Models Of Altered Akt Functionmentioning

confidence: 99%

PI3K/Akt: getting it right matters

2008

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“…Them4 is released from mitochondria in response to stimuli that promote apoptosis and helps to facilitate apoptosis by inhibiting Akt activation 28 . In a separate study of relatively similar design, Them4 was shown to induce Akt phosphorylation and reduce apoptosis, 30 although the reason for this discrepancy is unclear 31 . In hippocampal neurons, Them4 was found within cytosol, where it suppressed Akt activity and promoted ischemia-induced neuronal cell death 32 .…”

Section: Them4mentioning

confidence: 99%

New players on the metabolic stage

Cohen

2013

Adipocyte

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Members of the acyl-CoA thioesterase (Acot) gene family catalyze the hydrolysis of fatty acyl-CoA thioesters. Thioesterase superfamily member (Them) 1 (synonym: Acot11) is enriched in brown adipose tissue and is markedly upregulated when mice are exposed to cold ambient temperatures. In a recent study, we demonstrated that Them1−/− mice exhibit increased energy expenditure and are resistant to diet-induced obesity and its metabolic consequences. This mini-review places these findings in the context of an emerging understanding of Them/Acot genes.

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“…Although, CTMP has been emerged as one of Akt regulating protein, there are disparate views regarding the direction of regulation and no report about the association between CTMP and Akt regulation1011. To evaluate the association between CTMP expression and Akt activation, we evaluated Akt phosphorylation at Ser 473 after CTMP up-/down-regulation.…”

Section: Resultsmentioning

confidence: 99%

Carboxyl-Terminal Modulator Protein Positively Acts as an Oncogenic Driver in Head and Neck Squamous Cell Carcinoma via Regulating Akt phosphorylation

Chang

Jung

Kim

et al. 2016

Sci Rep

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The exact regulatory mechanisms of carboxyl-terminal modulator protein (CTMP) and its downstream pathways in cancer have been controversial and are not completely understood. Here, we report a new mechanism of regulation of Akt serine/threonine kinase, one of the most important dysregulated signals in head and neck squamous cell carcinoma (HNSCC) by the CTMP pathway and its clinical implications. We find that HNSCC tumor tissues and cell lines had relatively high levels of CTMP expression. Clinical data indicate that CTMP expression was significantly associated with positive lymph node metastasis (OR = 3.8, P = 0.033) and correlated with poor prognosis in patients with HNSCC. CTMP was also positively correlated with Akt/GSK-3β phosphorylation, Snail up-regulation and E-cadherin down-regulation, which lead to increased proliferation and epithelial-to-mesenchymal transition, suggesting that CTMP expression results in enhanced tumorigenic and metastatic properties of HNSCC cells. Moreover, CTMP suppression restores sensitivity to cisplatin chemotherapy. Intriguingly, all the molecular responses to CTMP regulation are identical regardless of p53 status in HNSCC cells. We conclude that CTMP promotes Akt phosphorylation and functions as an oncogenic driver and prognostic marker in HNSCC irrespective of p53.

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Akt-interacting proteins: attractive opposites. Focus on “Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways”

Cited by 20 publications

References 27 publications

PI3K/Akt: getting it right matters

PI3K/Akt: getting it right matters

New players on the metabolic stage

Carboxyl-Terminal Modulator Protein Positively Acts as an Oncogenic Driver in Head and Neck Squamous Cell Carcinoma via Regulating Akt phosphorylation

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