2002
DOI: 10.1002/cyto.10133
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Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: Potential therapeutic use in the treatment of inflammatory bowel disease

Abstract: BackgroundCytokines involved in inflammatory bowel disease (IBD) direct a predominantly cell‐mediated T‐ helper‐1 (Th1) immune response. The nonspecific anti‐inflammatory treatment being used in the management of patients with IBD has not changed much since the 1970s and new therapeutic agents are keenly sought. Several compounds isolated from Allium sativum (garlic) modulate leukocyte cell proliferation and cytokine production.MethodsTo investigate the possible therapeutic effects of garlic in the treatment o… Show more

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Cited by 186 publications
(131 citation statements)
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“…Allicin exhibits antiinflammatory effect by inhibiting cell-mediated T-helper 1 and inflammatory cytokines (TNF-a, IL-1a, IL-6, IL-8, T-cell IFN-g and IL-2) while upregulating IL-10 production (Hodge et al, 2002).…”
Section: Discussionmentioning
confidence: 99%
“…Allicin exhibits antiinflammatory effect by inhibiting cell-mediated T-helper 1 and inflammatory cytokines (TNF-a, IL-1a, IL-6, IL-8, T-cell IFN-g and IL-2) while upregulating IL-10 production (Hodge et al, 2002).…”
Section: Discussionmentioning
confidence: 99%
“…Reuter et al [16] have reviewed the therapeutic effects of garlic on cardiovascular system as well as its antibiotic, anticancer, antioxidant, immunomodulator y, antiinflammatory, hypoglycemic and hormone-like effects. Garlic also increases anti-inflammatory monocyte IL-10 production and decreases proinflammatory cytokines such as TNF-α, IL-1β, IL-6, IL-8, T cell interferon gamma, IL-2 [17] . Garlic, a natural substance, has also been shown to inhibit LPO [18] .…”
Section: Discussionmentioning
confidence: 99%
“…It has been reported that garlic extract suppresses the production of leukocyte inflammatory cytokines such as tumor necrosis factor-a (TNF-a), interleukin (IL)-1a, IL-6, and interferon-c in vitro and shows a therapeutic potential in the treatment of inflammatory bowel disease. 10 Its characteristic flavor and potent biological activities are due to its organosulfur compounds. 11 Garlic contains diverse organosulfur compounds such as S-allyl-l-cysteine, diallyl disulfide, diallyl trisulfide, ajoene, and allicin, which have potent antioxidative, antibacterial, antiviral, and anticancer properties.…”
Section: Introduction Gmentioning
confidence: 99%