ALOX5,LPA,MMP9andTPOgene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans

Camacho-Mejorado, Rafael; Gómez, Rocío; Torres‐Sánchez, Luisa; Hernández-Tobías, Esther Alhelí; Noris, Gino; Santana, Carla; Magaña, Jonathan J.; Orozco, Lorena; Peña-Dı́az, Aurora de la; Arenas-Sordo, María de la Luz; Meraz-Ríos, Marco Antonio; Majluf‐Cruz, Abraham

doi:10.1098/rsos.190775

Cited by 5 publications

(2 citation statements)

References 88 publications

(133 reference statements)

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“…The first one demonstrates the existence of single-nucleotide polymorphisms of genes that encode angiotensin-converting enzyme and angiotensinogen, which are specifically associated with the risk of cerebrovascular ischemic events in Mexican patients 57 . The second explores AOX, LPA, MMP9, and TPO genes single-nucleotide polymorphisms and their relationship with increased susceptibility to atherothrombosis in Mexican adults 58 .…”

Section: Atherogenesis Cardio-and Cerebrovascular Diseasementioning

confidence: 99%

Medical research at the Mexican Institute of Social Security: Seven decades of work, achievements, and challenges

Mercado¹,

Torres²,

Guerrero‐Romero³

et al. 2023

GMM

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Since its foundation, more than 75 years ago, the Mexican Institute of Social Security (IMSS) has carried out multidisciplinary research -biomedical, clinical and epidemiological-focused on understanding and solving the medical problems that afflict its beneficiaries (more than 50% of the Mexican population). Initially, research was the result of individual and isolated efforts. In the 1960s, a small number of researchers formed the first research groups. Currently, 240 full-time scientists work at five centers and 40 research units located in different states of Mexico. In addition, approximately 270 doctors carry out clinical research at different primary, secondary and tertiary care units. During these seven decades, IMSS scientists have made relevant contributions to medicine, which have not only helped increase knowledge on the etiopathogenesis of numerous diseases, but also their diagnosis, prognosis and treatment. This article presents an overview of medical research carried out at IMSS, based on a historical approach and a review of some of the most relevant contributions in different fields of research.

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Section: Atherogenesis Cardio-and Cerebrovascular Diseasementioning

confidence: 99%

Medical research at the Mexican Institute of Social Security: Seven decades of work, achievements, and challenges

Mercado¹,

Torres²,

Guerrero‐Romero³

et al. 2023

GMM

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“…57 El segundo explora polimorfismos de un solo nucleótido de los genes AOX, LPA, MMP9 y TPO y su relación con el aumento en la susceptibilidad de aterotrombosis en adultos mexicanos. 58…”

Section: Aterogénesis Enfermedad Cardio Y Cerebrovascularunclassified

La investigación médica en el Instituto Mexicano del Seguro Social: siete décadas de trabajo, logros y retos

Mercado¹,

Torres²,

Guerrero‐Romero³

et al. 2021

GMM

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The pathogenesis and potential therapeutic targets in sepsis

Zhang,

Jiang,

et al. 2023

MedComm

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Sepsis is defined as “a life‐threatening organ dysfunction caused by dysregulated host systemic inflammatory and immune response to infection.” At present, sepsis continues to pose a grave healthcare concern worldwide. Despite the use of supportive measures in treating traditional sepsis, such as intravenous fluids, vasoactive substances, and oxygen plus antibiotics to eradicate harmful pathogens, there is an ongoing increase in both the morbidity and mortality associated with sepsis during clinical interventions. Therefore, it is urgent to design specific pharmacologic agents for the treatment of sepsis and convert them into a novel targeted treatment strategy. Herein, we provide an overview of the molecular mechanisms that may be involved in sepsis, such as the inflammatory response, immune dysfunction, complement deactivation, mitochondrial damage, and endoplasmic reticulum stress. Additionally, we highlight important targets involved in sepsis‐related regulatory mechanisms, including GSDMD, HMGB1, STING, and SQSTM1, among others. We summarize the latest advancements in potential therapeutic drugs that specifically target these signaling pathways and paramount targets, covering both preclinical studies and clinical trials. In addition, this review provides a detailed description of the crosstalk and function between signaling pathways and vital targets, which provides more opportunities for the clinical development of new treatments for sepsis.

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ALOX5,LPA,MMP9andTPOgene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans

Cited by 5 publications

References 88 publications

Medical research at the Mexican Institute of Social Security: Seven decades of work, achievements, and challenges

Medical research at the Mexican Institute of Social Security: Seven decades of work, achievements, and challenges

La investigación médica en el Instituto Mexicano del Seguro Social: siete décadas de trabajo, logros y retos

The pathogenesis and potential therapeutic targets in sepsis

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