<i>Aloysia citriodora</i> Palau (lemon verbena) for insomnia patients: A randomized, double‐blind, placebo‐controlled clinical trial of efficacy and safety

Afrasiabian, Farshid; Ardakani, Mehran Mirabzadeh; Rahmani, Khaled; Azadi, Nammam Ali; Alemohammad, Zahra Banafsheh; Bidaki, Reza; Karimi, Mehrdad; Emtiazy, Majid; Hashempur, Mohammad Hashem

doi:10.1002/ptr.6228

Cited by 41 publications

(33 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Few studies have clinically demonstrated that lemon verbena can improve sleep quality and stress. For example, a clinical study in patients with insomnia reported improved perceived sleep quality after 4 weeks of lemon verbena intake [ 31 ]. In another study, lemon verbena extract reduced the number of awakenings during the night, and less reported anxiety after 3 weeks of intake in amateur athletes [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Anxiolytic Effect and Improved Sleep Quality in Individuals Taking Lippia citriodora Extract

et al. 2022

View full text Add to dashboard Cite

The current fast-moving, hectic lifestyle has increased the number of individuals worldwide with difficulties in managing stress, which in turn is also affecting their sleep quality. Therefore, the objective of the current study was to assess a natural plant-based dietary supplement comprised of lemon verbena (Lippia citriodora) extract, purified in phenylpropanoids, in alleviating stress and improving quality of sleep. A double-blind, placebo-controlled study was conducted for 8 weeks, followed by a 4-week washout period. Both validated questionnaires and functional tests were performed during the study, whereas questionnaires were used after the washout. As a result, the group taking the lemon verbena extract significantly reduced their perception of stress after 8 weeks, which was corroborated by a significant decrease in cortisol levels. After the washout period, the subjects reported to present even lower stress levels, due to the lasting effect of the ingredient. As for sleep quality, the subjects taking the supplement reported feeling better rested, with a stronger effect observed in women. Sleep tracking using a wearable device revealed that the supplement users improved their times in the deeper stages of sleep, specifically their percentage of time in deep sleep and REM. In conclusion, lemon verbena extract purified in phenylpropanoids is revealed as a natural solution to help individuals to improve their stress and sleep quality.

show abstract

Section: Discussionmentioning

confidence: 99%

Anxiolytic Effect and Improved Sleep Quality in Individuals Taking Lippia citriodora Extract

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Association of insomnia with chronic diseases, such as obesity, type 2 diabetes, cardiovascular disease, neurological issues including mood swings, increased mortality has been established as evidenced by available literature [5]. A survey suggests, more than 80% global population use plant extracts as medication for primary health care [6,7]. Ashwagandha found across India and south Asia, is a respected herb in traditional Indian Ayurveda, scientifically known as Withania somnifera (L.) Dunal.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study

Langade

Kanchi

Salve³

et al. 2019

Cureus

View full text Add to dashboard Cite

Introduction Insomnia is a prevalent sleep disorder that can profoundly impact a person's physical health and mental wellbeing. Most of the currently available drugs for insomnia exert adverse effects. Hence, alternative herbal therapies could be effective in treating insomnia. Ashwagandha, a proven "Rasayana" from ancient Ayurveda is having the required potential to treat insomnia. Objective To determine the efficacy and safety of Ashwagandha root extract in patients with insomnia and anxiety. Methods This was a randomized, double-blind, placebo-controlled study conducted at Prakruti Hospital, Kalwa, Maharashtra, India. A total of 60 patients were randomly divided into two groups: test (n = 40) and placebo (n = 20) in a randomization ratio of 2:1. Test product was a capsule containing highest concentration full-spectrum Ashwagandha root extract 300 mg, and the placebo was an identical capsule containing starch. Both treatments were given twice daily with milk or water for 10 weeks. Sleep actigraphy (Respironics Philips) was used for assessment of sleep onset latency (SOL), total sleep time (TST), sleep efficiency (SE) and wake after sleep onset (WASO). Other assessments were total time in bed (sleep log), mental alertness on rising, sleep quality, Pittsburgh Sleep Quality Index (PSQI), and Hamilton Anxiety Rating Scale (HAM-A) scales. Results Two patients, one from each group, did not complete study and the per-protocol dataset (n = 58) included 29 and 19 patients from test and placebo, respectively. The baseline parameters were similar in the two groups at baseline. The sleep onset latency was improved in both test and placebo at five and 10 weeks. However, the SOL was significantly shorter (p, 0.019) after 10 weeks with test [29.00 (7.14)] compared to placebo [33.94 (7.65)]. Also, significant improvement in SE scores was observed with Ashwagandha which was 75.63 (2.70) for test at the baseline and increased to 83.48 (2.83) after 10 weeks, whereas for placebo the SE scores changed from 75.14

show abstract

“…Questionnaires were used at three intervals; at the baseline, 2 and 4 weeks after the enrollment. Data analysis showed that scores of global PSQI (measuring sleep latency, habitual sleep efficiency, daytime dysfunction, and subjective sleep quality) and ISI in the Aloysia citriodora group were higher after 2 and 4 weeks of treatment when compared with the placebo group [131].…”

Section: Migrainementioning

confidence: 93%

Neuroprotective Potential of Limonene and Limonene Containing Natural Products

et al. 2021

View full text Add to dashboard Cite

Limonene is a monoterpene confined to the family of Rutaceae, showing several biological properties such as antioxidant, anti-inflammatory, anticancer, antinociceptive and gastroprotective characteristics. Recently, there is notable interest in investigating the pharmacological effects of limonene in various chronic diseases due to its mitigating effect on oxidative stress and inflammation and regulating apoptotic cell death. There are several available studies demonstrating the neuroprotective role of limonene in neurodegenerative diseases, including Alzheimer’s disease, multiple sclerosis, epilepsy, anxiety, and stroke. The high abundance of limonene in nature, its safety profile, and various mechanisms of action make this monoterpene a favorable molecule to be developed as a nutraceutical for preventive purposes and as an alternative agent or adjuvant to modern therapeutic drugs in curbing the onset and progression of neurodegenerative diseases. This manuscript presents a comprehensive review of the available scientific literature discussing the pharmacological activities of limonene or plant products containing limonene which attribute to the protective and therapeutic ability in neurodegenerative disorders. This review has been compiled based on the existing published articles confined to limonene or limonene-containing natural products investigated for their neurotherapeutic or neuroprotective potential. All the articles available in English or the abstract in English were extracted from different databases that offer an access to diverse journals. These databases are PubMed, Scopus, Google Scholar, and Science Direct. Collectively, this review emphasizes the neuroprotective potential of limonene against neurodegenerative and other neuroinflammatory diseases. The available data are indicative of the nutritional use of products containing limonene and the pharmacological actions and mechanisms of limonene and may direct future preclinical and clinical studies for the development of limonene as an alternative or complementary phytomedicine. The pharmacophore can also provide a blueprint for further drug discovery using numerous drug discovery tools.

show abstract

Aloysia citriodora Palau (lemon verbena) for insomnia patients: A randomized, double‐blind, placebo‐controlled clinical trial of efficacy and safety

Cited by 41 publications

References 37 publications

Anxiolytic Effect and Improved Sleep Quality in Individuals Taking Lippia citriodora Extract

Anxiolytic Effect and Improved Sleep Quality in Individuals Taking Lippia citriodora Extract

Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study

Neuroprotective Potential of Limonene and Limonene Containing Natural Products

Contact Info

Product

Resources

About