2018
DOI: 10.1136/thoraxjnl-2017-210325
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Alternaria sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics

Abstract: In the non-selected birth cohort Tucson Children's Respiratory Study, early sensitisation to was associated with increased airway hyper-responsiveness (AHR) into adult life among non-asthmatics. The increase in AHR was of a similar magnitude to that seen for sensitised asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitisation to aeroallergens other than and AHR among non-asthmatics. Why this group of sensitised i… Show more

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Cited by 4 publications
(5 citation statements)
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“…The increase in AHR was of a similar magnitude to that seen for Alternaria-sensitized asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitization to aeroallergens other than Alternaria and AHR among nonasthmatics [80]. These observations indicate that, in clinical practice, physicians should always ask about the "atopic march" (atopic dermatitis, food allergy, and allergic rhinitis) in childhood.…”
Section: Atopy Allergy Eczema: the Atopic Marchmentioning
confidence: 82%
“…The increase in AHR was of a similar magnitude to that seen for Alternaria-sensitized asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitization to aeroallergens other than Alternaria and AHR among nonasthmatics [80]. These observations indicate that, in clinical practice, physicians should always ask about the "atopic march" (atopic dermatitis, food allergy, and allergic rhinitis) in childhood.…”
Section: Atopy Allergy Eczema: the Atopic Marchmentioning
confidence: 82%
“…Adults with asthma who are sensitive to mold have more hospital admissions overall and admissions to the intensive care unit for asthma exacerbations 810. In addition, sensitization to Alternaria is associated with airway hyper-responsiveness in non-asthmatic adults15 and in children with mild to moderate asthma 3. Interestingly, as in adult populations, our general pediatric population had an association of sensitization to Alternaria with airway dysfunction, as determined by resistance at 10 Hz, 15 Hz and 20 Hz, but not at Rrs20-5 (which represents small airway dysfunction) 16.…”
Section: Discussionmentioning
confidence: 99%
“…4,5 Alternaria alternata has been described as the most important mold agent associated with respiratory allergies and severe asthma, 6,7 especially in children. [8][9][10] The most intense exposure to A. alternata allergens is likely to occur outdoors; however, Alternaria and other allergenic fungi can colonize indoor environments and thereby increase the fungal aeroallergen exposure levels. A consequence of human exposure to fungal aeroallergens, sensitization to A. alternata, has been unequivocally associated with increased asthma severity and persistence.…”
Section: Introductionmentioning
confidence: 99%