<i>Angiostrongylus cantonensis</i> Infection of Central Nervous System, Guiana Shield

Defo, Antoine; Lachaume, Noémie; Cuadro-Alvarez, Emma; Maniassom, Chimène; Martin, Élise; Njuieyon, Falucar; Henaff, Fanny; Mrsic, Yajaira; Brunelin, Annabelle; Epelboin, Loïc; Blanchet, Denis; Harrois, Dorothée; Desbois‐Nogard, Nicole; Qvarnström, Yvonne; Demar, Magalie; Dard, Céline; Elenga, Narcisse

doi:10.3201/eid2406.180168

Cited by 13 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…La frecuencia de las infecciones por A. cantonensis en humanos probablemente no se notifica debido a una combinación de factores, incluido el frecuente curso autolimitado de la infección, la falta de conocimiento del parásito, la disponibilidad limitada de pruebas de diagnóstico y la falta de vigilancia nacional. Aunque en la mayoría de los casos la enfermedad se resuelve espontáneamente, las tasas de letalidad pueden alcanzar el 5 % (40,41).…”

Section: Discussionunclassified

Angiostrongylus (Parastrongylus) cantonensis en huéspedes intermediarios y definitivos en Ecuador, 2014-2017

2019

View full text Add to dashboard Cite

Introducción. Angiostrongylus cantonensis es un serio problema de salud pública y está ampliamente distribuido en el país. Cuando el parásito infecta a los caracoles terrestres Achatina, se enquista en su interior y puede infectar accidentalmente a las personas y otros mamíferos.Objetivo. Establecer la distribución geográfica de A. cantonensis en huéspedes intermediarios (Achatina fulica) y definitivos (Rattus spp.) en Ecuador entre el 2014 y el 2017.Materiales y métodos. Se recolectaron 2.908 ejemplares de A. fulica en 16 provincias utilizando el método de captura por unidad de esfuerzo durante 30 minutos. Se capturaron 211 ejemplares de las especies huéspedes, de los cuales 20 eran Rattus rattus y 191 R. norvegicus. Los ejemplares fueron transportados para su análisis al Instituto Nacional de Salud Pública e Investigación en Guayaquil.En los tejidos del caracol se identificaron y se contabilizaron larvas L3 que luego se inocularon en ratas de laboratorio para reproducir el ciclo de vida. En los roedores se disecaron los cerebros, los corazones, las arterias pulmonares y los pulmones, y se identificaron los parásitos por morfología taxonómica.Resultados. De los caracoles recolectados se encontraron 441 positivos para A. cantonensis (15,2 %) y un total de 6.166 larvas L3. En los ejemplares Rattus spp. capturados (211), 77 (36,5 %) estaban infectados con A. cantonensis, con un total de 220 parásitos (larvas L4-L5 y adultos).Conclusiones. Se constató la presencia de A. cantonensis en varias provincias, lo que confirma el carácter endémico de esta zoonosis en el territorio nacional. La presencia de Rattus spp., huésped definitivo del parásito, y de huéspedes intermediarios, indica el potencial zoonótico de esta infección parasitaria.

show abstract

Section: Discussionunclassified

Angiostrongylus (Parastrongylus) cantonensis en huéspedes intermediarios y definitivos en Ecuador, 2014-2017

2019

View full text Add to dashboard Cite

show abstract

“…The global distribution, by country, of combined reported presence of Angiostrongylus cantonensis and cases of human or animal neuroangiostrongyliasis (red circles), with cases in returning travelers to nonendemic areas distinguished (blue circles). 2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] If part of a country is distant from the main part of the country-Guam, Saipan, Hawaii, American Samoa, and Puerto Rico (United States); Ryukyu and Ogasawara Islands (Japan); New Caledonia, Tahiti, Mayotte, R eunion, Guadeloupe, and Martinique (France); and Canary Islands and Mallorca (Spain)-dots are placed on those locations in addition to the main part of country (if also present there). For most countries/territories, a single dot has been placed roughly where the greatest concentration of records occurs.…”

Section: Infection Pathwaysmentioning

confidence: 99%

Neuroangiostrongyliasis: Global Spread of an Emerging Tropical Disease

Cowie

Ansdell

Dunavan

et al. 2022

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Neuroangiostrongyliasis (NAS) is an emerging parasitic disease caused by the neurotropic nematode Angiostrongylus cantonensis. Since it was first discovered, in rats in southern China in the 1930s, this tropical to subtropical parasite has spread to much of Southeast Asia, the Pacific Islands (including Hawaii), Australia, Japan, South America, the southeastern United States, the Caribbean, Africa, the Canary Islands, and the Balearic Islands. The parasite completes its natural life cycle in snails and slugs (intermediate hosts), and rats (definitive hosts). Humans become accidental hosts after ingesting infective third-stage larvae contained within uncooked or undercooked intermediate or paratenic hosts, an event that sometimes results in NAS, also known as rat lungworm disease. Although A. cantonensis larvae cannot complete their life cycle in humans, their migration into the brain and spinal cord combined with a powerful inflammatory reaction often leads to eosinophilic meningitis and can, in rare instances, lead to coma, paralysis, and death or, in other cases, chronic, disabling neurologic sequelae. Symptoms of NAS are diverse, which often makes it difficult to diagnose. Treatment may include administration of analgesics, corticosteroids, anthelminthics, and repeat lumbar punctures to reduce intracranial pressure. Unfortunately, few medical providers, even in endemic areas, are familiar with A. cantonensis or its epidemiology, diagnosis, and treatment. As the parasite continues to spread and NAS affects more people, medical practitioners, as well as the general public, must become more aware of this emerging zoonosis and the potentially devastating harm it can cause.

show abstract

“…Aspergillus is a classical cause of meningitis, vasculitis and brain abscess in immunosuppressed patients [29] but diffuse encephalitis as observed in our case is very unusual, particularly in immunocompetent subjects [30]. Myelitis caused by infection of Angiostrongillus cantonensis is a rare condition [31] although it is the most common eosinophilic meningitis worldwide.…”

Section: Discussionmentioning

confidence: 76%

Central nervous system infections in a tropical area: influence of emerging and rare infections

Chaumont

Roze

Tressières³

et al. 2020

Euro J of Neurology

View full text Add to dashboard Cite

Background and purpose: The frequency of infectious encephalitis and the distribution of causative pathogens in tropical areas are poorly known and may be influenced by emerging and rare infections. The aim was to characterize a large series of acute infectious encephalitis and myelitis in immunocompetent patients from the Caribbean island of Guadeloupe identifying clinical, biological and radiological features according to pathogens. Methods: Using a hospital database, detailed information on a comprehensive series of immunocompetent patients with acute infectious myelitis and encephalitis over the 2012-2018 period was retrospectively collected. Results: From 259 suspected cases with acute central nervous system infection, 171 cases were included for analysis, comprising 141 encephalitis, 22 myelitis and eight encephalomyelitis. The annual incidence peaked at 15.0/ 100 000 during the Zika 2016 outbreak. Children accounted for 22.2% of cases. Eight adults died during hospital stay, all encephalitis. Seventeen infectious agents, two of which had never been described in Guadeloupe so far, were identified in 101 cases (59.1%), including 35 confirmed cases (34.7%), 48 probable cases (47.5%), 15 possible cases (14.9%) and three clinical cases (3.0%). The most frequent etiologic agents were Zika virus in 23 cases (13.5%), herpes simplex in 12 (7.0%), varicella zoster virus in 11 (6.4%), dengue virus in 11 (6.4%) and leptospirosis in 11 (6.4%). Conclusions: The Zika outbreak had a major influence on the annual incidence of acute central nervous system infection. Acute neuroleptospirosis is over-represented in our series. Further efforts are mandatory to develop new diagnostic tools for pathogen profiling.

show abstract

Angiostrongylus cantonensis Infection of Central Nervous System, Guiana Shield

Cited by 13 publications

References 8 publications

Angiostrongylus (Parastrongylus) cantonensis en huéspedes intermediarios y definitivos en Ecuador, 2014-2017

Angiostrongylus (Parastrongylus) cantonensis en huéspedes intermediarios y definitivos en Ecuador, 2014-2017

Neuroangiostrongyliasis: Global Spread of an Emerging Tropical Disease

Central nervous system infections in a tropical area: influence of emerging and rare infections

Contact Info

Product

Resources

About