<i>Angiotensin-converting enzyme</i> insertion/deletion gene polymorphism and risk of intracranial aneurysm in a Chinese population

Liu, Yi; Li, Peng; Hu, Xiao; Hu, Yu; Sun, Hao-Gen; Ma, Weichao; Qiao, Fang; He, Min; You, Chao

doi:10.1177/0300060513487625

Cited by 5 publications

(6 citation statements)

References 48 publications

(76 reference statements)

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“…Polymorphisms within the kallikrein gene cluster are associated with intracranial aneurysms suggesting that the kallikreins are important candidate genes for intracranial aneurysms [ 22 ]. Evidence from a case-control study suggested that the angiotensin-converting enzyme DD genotype might be a protective factor for intracranial aneurysms in a Chinese population [ 23 ]. Evidence from a meta-analysis of case-control studies also suggested that there was a close relationship between angiotensin-converting enzyme I/D polymorphism and intracranial aneurysms risk [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein E polymorphism and the risk of intracranial aneurysms in a Chinese population

et al. 2016

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BackgroundThe relationship between the apolipoprotein E (APOE) polymorphism and intracranial aneurysms has previously only been studied in Russia and Japan but not in Chinese populations. The purpose of this study was to investigate the association between APOE polymorphism and the risk of intracranial aneurysms in a Chinese population.MethodsThe study population consisted of 150 intracranial aneurysms patients and 150 matched control subjects. The APOE gene polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).ResultsPatients with intracranial aneurysms had a significantly higher frequency of APOE E2/E2 genotype [odds ratio (OR) =9.51, 95 % confidence interval (CI) = 1.19, 76.04; P = 0.03] and APOE E2/E3 genotype (OR = 1.87, 95 % CI = 1.03, 3.40; P = 0.04) than healthy controls. The APOE E4/E4 genotype frequencies (OR = 0.09, 95 % CI = 0.01, 0.74; P = 0.03) in the intracranial aneurysms group were significantly lower than those in the controls group. When stratified by the site, shape, size and the Fisher Grade of intracranial aneurysms, no statistically significant result was observed.ConclusionOur study suggested that APOE polymorphism might be associated with intracranial aneurysms in Chinese population. Additional studies are needed to confirm this finding.

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Section: Discussionmentioning

confidence: 99%

Apolipoprotein E polymorphism and the risk of intracranial aneurysms in a Chinese population

et al. 2016

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“…A recent study showed that patients with LVH tend to have higher rates of DD genotype. 26 So, the LVH is also a common complication in coronary disease. Altogether, comparison of the distribution of patients' characteristics according to the genotypes of the ACE I/D polymorphism showed no significant differences in all characteristics except for the percentage of patients' survival after SCA and patients' death by SCA, which is an interesting result.…”

Section: Discussionmentioning

confidence: 99%

“…Peripheral blood was collected and DNA was extracted from leukocytes as described earlier. 26 Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze ACE I/D gene polymorphisms.…”

Section: The Ace I/d Genotypementioning

confidence: 99%

Role of angiotensin‐converting enzyme insertion/deletion polymorphism in sudden cardiac arrest

Liu

Wang

Zhang

et al. 2018

J of Cellular Biochemistry

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Objective: This study aimed to investigate the relationship between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and to understand sudden cardiac arrest (SCA) in the Chinese population. Methods: In this study, 232 patients were divided into the SCA group and the coronary disease group with coronary disease, but no SCA occurred during the treatment period. After comparing the genotype frequencies of the two groups, all patients were further divided into three groups as the II homozygotes, ID heterozygotes, and DD homozygotes to investigate the relationship in ACE I/D polymorphism and other risk factors of SCA.Results: The frequencies of DD genotype in the SCA group were significantly higher than the coronary disease group, as well as the D allele frequencies in the SCA group were high when compared with the coronary disease group. According to the genotypes of the ACE I/D polymorphism, the distribution of patients' characteristics had no significant differences among all the characteristics. Both, the patients who survived SCA, with II genotype and the ones who died of SCA, with DD genotype had significant higher percentages. Conclusion:The DD genotype was associated with a higher prevalence of SCA and might be a risk factor of survival rate in sudden cardiac death. K E Y W O R D Sangiotensin-converting enzyme, insertion/deletion polymorphism, sudden cardiac arrest

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“…In addition, Liu et al (17) reported that no statistically significant differences were identified between genotypes in patients with IA, when stratified by the site, shape, size and Fisher Grade of aneurysms (17). In future studies, greater focus on clinical characteristics, such as gender, alcohol consumption, smoking, family history, and site, shape, size and Fisher Grade of IA should be taken into consideration to provide a more powerful analytical framework.…”

Section: Codominant Model -------------------------------------------mentioning

confidence: 99%

“…Certain previous studies investigated the influence of ACE I/D gene polymorphisms on IA susceptibility (17)(18)(19)(20)(21)(22)(23); however, the results of these studies remain inconsistent. As a single study might not be powered to demonstrate the overall effects, Association between angiotensin-converting enzyme insertion/deletion polymorphisms and intracranial aneurysm susceptibility: A meta-analysis a meta-analysis using currently available data was performed in the present study to detect the potential association of ACE I/D gene polymorphisms on IA risk.…”

Section: Introductionmentioning

confidence: 99%

Association between angiotensin-converting enzyme insertion/deletion polymorphisms and intracranial aneurysm susceptibility: A meta-analysis

et al. 2017

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Abstract.Various studies have evaluated the association between polymorphisms of angiotensin-converting enzyme (ACE) and intracranial aneurysm (IA) risk; however, the results remain inconsistent. The PubMed, Embase, and Wanfang Data databases were systematically searched until January 6th 2016. Case-control studies investigating the association between the ACE polymorphism and IA risk were included. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated with the fixed or random-effects model assuming allele, homozygote comparison of codominant, heterozygote comparison of codominant, dominant, and recessive models. Seven studies including 1,074 cases and 1,500 controls were included in the current meta-analysis. The results of the analysis indicated that the ACE polymorphism significantly increased IA risk in the allele, homozygote comparison of codominant and dominant models. According to the further stratified analysis by ethnicity, source of control and sample sizes, a significant association was identified between the ACE variant and IA risk in Asian individuals, hospital-based, or large (>300) subgroups in all of the genetic models, not including the recessive model. Furthermore, no significantly increased risk was indicated in Caucasian individuals, population-based, or small (<300) subgroups in the heterozygote comparison of codominant, dominant and recessive models. The available evidence indicates that the ACE polymorphism is associated with an increased risk of IA, particularly in Asian individuals. However, other factors may impact this association. Further large, well-designed multicenter studies are required to validate the findings from the present study.

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Angiotensin-converting enzyme insertion/deletion gene polymorphism and risk of intracranial aneurysm in a Chinese population

Cited by 5 publications

References 48 publications

Apolipoprotein E polymorphism and the risk of intracranial aneurysms in a Chinese population

Apolipoprotein E polymorphism and the risk of intracranial aneurysms in a Chinese population

Role of angiotensin‐converting enzyme insertion/deletion polymorphism in sudden cardiac arrest

Association between angiotensin-converting enzyme insertion/deletion polymorphisms and intracranial aneurysm susceptibility: A meta-analysis

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