“…Alkynes are one of the most flexible building blocks and widely used as sustainable feedstocks for chemical synthesis, as well as in the production of numerous medications and materials. , Catalytic difunctionalization of these π systems is a direct and efficient method to access a variety of structurally diverse trisubstituted compounds. − Trisubstituted alkenes are pivotal structural motifs in the structure of numerous medicines − and materials, as well as helpful precursors for other functional groups and chiral centers . The methods employed, however, rely heavily on the use of organometallic species and require high-temperature or multistep reactions (Scheme a). − More recently, radical-mediated reactions have been devised, which provide an effective technique for difunctionalizing terminal alkynes. − In general, a radical is generated from various radical precursors, such as sulfonyl chlorides, α,β-unsaturated ketones, activated alkyl bromides, fluoroalkyl iodides, etc., − which is via a single electron transfer (SET) process employing transition metal species, − photocatalysts, − or electrocatalysis (Scheme b). These processes are usually transition metal-catalyzed multicomponent reactions, and heavy metal residues are long-standing issues.…”