<i>Artemisia sieversiana</i> Ehrhart ex Willd. Essential Oil and Its Main Component, Chamazulene: Their Photoprotective Effect against UVB-Induced Cellular Damage and Potential as Novel Natural Sunscreen Additives

Zhou, Ying; He, Lei; Wang, Wencui; Wei, Guodong; Ma, Li; Liu, Huanyan; Yao, Lei

doi:10.1021/acssuschemeng.3c04804

Cited by 5 publications

(4 citation statements)

References 70 publications

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“…Among the volatile oil components of chamomile, besides chamazulene, the oxygenated sesquiterpenes are the most characteristic, with bisabolol oxide B, α -bisabolol, bisabolone oxide, and bisabolol oxide A being the most notable compounds [ 18 ]. Chamazulene offers photoprotective effects on the human keratinocyte cell line (HaCaT) and provides ultraviolet blocking capabilities [ 26 ]; α-Bisabolol inhibited glioblastoma cell migration and invasion by downregulating central mucoepidermoid tumor (c-Met); α -Bisabolol oxide A from chamomile flowers is reported to inhibit the migration of Caco-2 colon cancer cells and deactivate the vascular epidermal growth factor receptor-2 (VEGFR2) angiogenic enzymes [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

GC–MS Combined with Fast GC E-Nose for the Analysis of Volatile Components of Chamomile (Matricaria chamomilla L.)

Lu,

Jiang,

Dang

et al. 2024

Foods

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Chamomile has become one of the world’s most popular herbal teas due to its unique properties. Chamomile is widely used in dietary supplements, cosmetics, and herbal products. This study aimed to investigate the volatile aromatic components in chamomile. Two analytical techniques, gas chromatography–mass spectrometry (GC-MS) and an ultra-fast gas chromatography electronic nose, were employed to examine samples from Xinjiang (XJ), Shandong (SD), and Hebei (HB) in China, and imported samples from Germany (GER). The results revealed that all chamomile samples contained specific sesquiterpene compounds, including α-bisabolol, bisabolol oxide, bisabolone oxide, and chamazulene. Additionally, forty potential aroma components were identified by the electronic nose. The primary odor components of chamomile were characterized by fruity and spicy notes. The primary differences in the components of chamomile oil were identified as (E)-β-farnesene, chamazulene, α-bisabolol oxide B, spathulenol and α-bisabolone oxide A. Significant differences in aroma compounds included geosmin, butanoic acid, 2-butene, norfuraneol, γ-terpinene. This study demonstrates that GC–MS and the ultra-fast gas chromatography electronic nose can preliminarily distinguish chamomile from different areas, providing a method and guidance for the selection of origin and sensory evaluation of chamomile. The current study is limited by the sample size and it provides preliminary conclusions. Future studies with a larger sample size are warranted to further improve these findings.

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Section: Resultsmentioning

confidence: 99%

GC–MS Combined with Fast GC E-Nose for the Analysis of Volatile Components of Chamomile (Matricaria chamomilla L.)

Lu,

Jiang,

Dang

et al. 2024

Foods

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“…Hence, CA has indirect antioxidant properties, beside showing reactivity toward different radicals [11]. EOs are well-perceived natural sources of bioactives of widespread use in cosmetics and food products [12,13], and CA, has gained popularity as an ingredient in cosmetic skin-and hair-care products, also owing to its reported photoprotective activity, able to prevent UVB-induced photodamage [14]. Paradoxically, this last property might actually turn into a matter of concern.…”

Section: Introductionmentioning

confidence: 99%

Photochemical and Oxidative Degradation of Chamazulene Contained in Artemisia, Matricaria and Achillea Essential Oils and Setup of Protection Strategies

Gabbanini,

Neba,

Matera

et al. 2024

Preprint

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Chamazulene (CA) is an intensely blue molecule with a wealth of biological properties. In cosmetics chamazulene is exploited as a natural coloring and soothing agent. CA is unstable and tends to spontaneous degradation accelerated by light. We studied the photodegradation of CA upon controlled exposure to UVB-UVA irradiation by multi-ple techniques, including GC-MS, UHPLC-PDA-ESI-MS/MS and by direct infusion in ESI-MSn, which were matched to in silico mass spectral simulations to identify degra-dation products. Seven byproducts formed upon UVA exposure for 3 h at 70mW/cm2 (blue-to-green color change) were identified, including CA dimers and CA benzenoid which were not found on extended 6 h irradiation (green-to-yellow fading). Photosta-bility tests with reduced irradiance conducted in various solvents in the pres-ence/absence of air indicated highest degradation in acetonitrile in the presence of ox-ygen, suggesting a photo-oxidative mechanism. Testing in the presence of antioxidants (tocopherol, ascorbyl palmitate, hydroxytyrosol, bakuchiol, γ-terpinene, TEMPO and their combinations) indicated highest protection by tocopherol and TEMPO. Sun-screens ethylhexyl methoxycinnamate and particularly Tinosorb® S (but not octo-crylene) showed good CA photoprotection. Thermal stability tests indicated no degra-dation of CA in acetonitrile at 50°C in the dark for 50 days; however, accelerated deg-radation occurred in the presence of ascrorbyl palmitate.

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“…Hence, CA has indirect antioxidant properties, besides showing reactivity toward different radicals [ 11 ]. EOs are well-perceived natural sources of bioactives of widespread use in cosmetics and food products [ 12 , 13 ], and CA has gained popularity as an ingredient in cosmetic skin- and hair-care products, also owing to its reported photoprotective activity, making it able to prevent UVB-induced photodamage [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Photochemical and Oxidative Degradation of Chamazulene Contained in Artemisia, Matricaria and Achillea Essential Oils and Setup of Protection Strategies

Gabbanini,

Neba,

Matera

et al. 2024

Molecules

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Chamazulene (CA) is an intensely blue molecule with a wealth of biological properties. In cosmetics, chamazulene is exploited as a natural coloring and soothing agent. CA is unstable and tends to spontaneously degrade, accelerated by light. We studied the photodegradation of CA upon controlled exposure to UVB-UVA irradiation by multiple techniques, including GC-MS, UHPLC-PDA-ESI-MS/MS and by direct infusion in ESI-MSn, which were matched to in silico mass spectral simulations to identify degradation products. Seven byproducts formed upon UVA exposure for 3 h at 70 mW/cm2 (blue-to-green color change) were identified, including CA dimers and CA benzenoid, which were not found on extended 6 h irradiation (green-to-yellow fading). Photostability tests with reduced irradiance conducted in various solvents in the presence/absence of air indicated highest degradation in acetonitrile in the presence of oxygen, suggesting a photo-oxidative mechanism. Testing in the presence of antioxidants (tocopherol, ascorbyl palmitate, hydroxytyrosol, bakuchiol, γ-terpinene, TEMPO and their combinations) indicated the highest protection by tocopherol and TEMPO. Sunscreens ethylhexyl methoxycinnamate and particularly Tinosorb® S (but not octocrylene) showed good CA photoprotection. Thermal stability tests indicated no degradation of CA in acetonitrile at 50 °C in the dark for 50 days; however, accelerated degradation occurred in the presence of ascorbyl palmitate.

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Artemisia sieversiana Ehrhart ex Willd. Essential Oil and Its Main Component, Chamazulene: Their Photoprotective Effect against UVB-Induced Cellular Damage and Potential as Novel Natural Sunscreen Additives

Cited by 5 publications

References 70 publications

GC–MS Combined with Fast GC E-Nose for the Analysis of Volatile Components of Chamomile (Matricaria chamomilla L.)

GC–MS Combined with Fast GC E-Nose for the Analysis of Volatile Components of Chamomile (Matricaria chamomilla L.)

Photochemical and Oxidative Degradation of Chamazulene Contained in Artemisia, Matricaria and Achillea Essential Oils and Setup of Protection Strategies

Photochemical and Oxidative Degradation of Chamazulene Contained in Artemisia, Matricaria and Achillea Essential Oils and Setup of Protection Strategies

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