Aspergillus fumigatus peritonitis in ambulatory peritoneal dialysis: A case report and notes on the therapeutic approach (Case Report)

Abstract

Aspergillus peritonitis is a rare disease in continuous peritoneal dialysis. It is a severe form of peritonitis, which is frequently lethal. We report a case of Aspergillus fumigatus peritonitis in a female patient on automated peritoneal dialysis (APD), who was successfully treated with intravenous amphotericin B and the removal of the peritoneal catheter. As delayed treatment has an increased mortality rate, it is mandatory to remove the catheter and to start intravenous treatment with amphotericin B empirically.

Fungal Biofilms, Drug Resistance, and Recurrent Infection

“…Dialysis catheters (Bonfante et al 2005;Jeloka et al 2011) A. fumigatus Galactomannan, a-1,3-glucans, monosaccharides, polyols, melanins, and proteins such as hydrophobins ) and DNA (Rajendran et al 2013) Hyphal cells embedded in ECM (Loussert et al 2010;Rajendran et al 2013) other cells and surfaces is vital for biofilm stability. Consistent with this conclusion, some biofilm-defective mutants, such as bcr1D/D or rhr2D/D, are able to form hyphae under biofilm conditions, but fail to express hyphal adhesin genes (Nobile et al 2006;Finkel et al 2012;Desai et al 2013).…”

Peritonitis Due to Blastobotrys proliferans in a Patient Undergoing Continuous Ambulatory Peritoneal Dialysis

“…Aspergillus spp. are responsible for a severe form of peritonitis, frequently lethal, and require prompt removal of the Tenckoff catheter while starting intravenous amphotericin B (2,22,23). Zygomycetes remain an uncommon cause of peritonitis associated with a high mortality rate of 57% (23).…”

Aspergillus fumigatus a rare cause of peritonitis in a peritoneal dialysis patient: a case report

“…Although it rarely causes peritonitis in the PD population, Aspergillus is associated with mortality rates of up to 50% [ 5 ]. This is attributed to delays in diagnosis, failure to remove the Tenckhoff catheter, and limited therapeutic options [ 6 ]. Confirmation of invasive Aspergillus spp infection is challenging due to potential specimen contamination, frequent respiratory colonization, potential laboratory contamination of culture specimens and suboptimal sensitivity for isolation of Aspergillus spp using routine culture methods [ 7 ].…”