<i>Aspergillus</i>-related lung disease in people with cystic fibrosis: can imaging help us to diagnose disease?

Lv, Qianting; Elders, Bernadette; Warris, Adilia; Caudri, Daan; Ciet, Pierluigi; Tiddens, Harm A.W.M.

doi:10.1183/16000617.0103-2021

Cited by 9 publications

(7 citation statements)

References 129 publications

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“…These coinfected pathogens might release cytotoxic substances that cause damages to the epithelium, favoring the colonization and germination of A. fumigatus. The medicine used for other co-infected pathogens might also counteract antifungal medicine (Lv et al, 2021). In this study, we found that A. fumigatus could stimulate G-CSF production, which contributed to the activation of neutrophils with lower apoptosis rate (Figures 6A,B and Supplementary Figures 1B,C), which implies a pleiotropic role of G-CSF and neutrophils during infections.…”

Section: Discussionmentioning

confidence: 56%

Suppression of Aspergillus fumigatus Germination by Neutrophils Is Enhanced by Endothelial-Derived CSF3 Production

Zhang

Wei

et al. 2022

Front. Microbiol.

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Infection with Aspergillus fumigatus can cause life-threatening diseases in immunocompromised patients with an unacceptable mortality rate. Angioinvasion is one of the features of severe invasive aspergillosis. Neutrophils are short-lived immune cells regulated by colony-stimulating factor 3 (CSF3) that play a key role in anti-fungal immune responses. To investigate the interactions between A. fumigatus and the host immune cells, such as neutrophils, we stimulated human umbilical vein endothelial cells (HUVECs) with the conidia of A. fumigatus, and co-cultured them with human neutrophils. Apoptosis and functions of neutrophils were analyzed. Our results showed that HUVECs upregulate the expression of CSF3, which could reduce the apoptosis of neutrophils while enhancing their functions. Lack of CSF3 was associated with enhanced apoptosis of neutrophils with impaired function. This work indicated that the CSF3 is required for neutrophil survival and function, at least in the early stages of A. fumigatus infection.

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Section: Discussionmentioning

confidence: 56%

Suppression of Aspergillus fumigatus Germination by Neutrophils Is Enhanced by Endothelial-Derived CSF3 Production

Zhang

Wei

et al. 2022

Front. Microbiol.

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“…The lack of evaluating chest imaging is also a limitation of our study because it has been shown that Aspergillus spp. is associated with structural lung disease 15,39,40 . On the other hand, the strength of our study is its prospective longitudinal design.…”

Section: Discussionmentioning

confidence: 95%

“…is associated with structural lung disease. 15,39,40 On the other hand, the strength of our study is its prospective longitudinal design.…”

Section: In Conclusion Althoughmentioning

confidence: 99%

A case‐control study of the effects of Aspergillus clinical phenotypes on pulmonary functions in patients with cystic fibrosis

Büyükşahin

Doğru

Emiralioğlu

et al. 2023

Pediatric Pulmonology

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Introduction There are no precise data about the effect of Aspergillus infection on lung function other than allergic bronchopulmonary aspergillosis (ABPA) in patients with cystic fibrosis (pwCF). Here, we aimed to determine clinical phenotypes caused by Aspergillus spp. using laboratory and immunologic parameters and to compare Aspergillus phenotypes in terms of pulmonary function tests (PFT) prospectively. Methods Twenty‐three pwCF who had Aspergillus isolation from respiratory cultures in the last year (case group) and 20 pwCF without Aspergillus isolation in sputum (control group) were included. Aspergillus immunoglobulin (Ig)‐G, Aspergillus IgE, Aspergillus polymerase chain reaction (PCR), galactomannan, total IgE from blood samples, and Aspergillus PCR and galactomannan from sputum, and skin prick test reactivity to Aspergillus antigen were used to distinguish different Aspergillus phenotypes. Pulmonary functions and frequency of pulmonary exacerbations were evaluated during a 1‐year follow‐up. Results Of 23 pwCF, 11 (47.8%) had Aspergillus colonization, nine (39.1%) had Aspergillus bronchitis, and three (13%) had ABPA. Aspergillus infection was not associated with worse z‐scores of forced expiratory volume in the first second (FEV1) (p = 0.612), forced vital capacity (p = 0.939), and the median FEV 1% decline (0.0%/year vs. −4.7%/year, p = 0.626). The frequency of pulmonary exacerbations in the Aspergillus infected and noninfected groups was similar. Conclusion Although Aspergillus spp. Isolation in pwCF was not associated with decreased lung function, a further decline was seen in the ABPA subgroup, and frequent pulmonary exacerbations during the 1‐year follow‐up.

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“…[6] Patients with pre-existing conditions such as asthma or cystic fibrosis are more likely to develop allergic forms of aspergillosis. [7] The chronic forms of aspergillosis are associated with long-term cough or other pulmonary and systemic symptoms. It is most commonly observed in patients with lung damage but with no significant immunocompromise.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Overview of Various Fungal Menaces Amidst Corona Virus Disease

C¹

2023

Journal of Pharmaceutical Negative Results

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The disastrous Coronavirus Disease outbreak declared as a global pandemic, has become a potential hazard to public health. The second wave of COVID-19 in India has been strongly linked to the rising cases of various fungal infections including mucormycosis, aspergillosis, candidiasis, and mucor septicus. These fungal infections have been a cause for alarm for the general public. The color-coding of the fungal infections is primarily based on the symptoms observed in the infected patients and not based on the color of the fungi itself. For busting the myths behind fungal infections, a comprehensive and deeper understanding of the facts is needed to overcome this challenge. Rapid diagnosis, reversal of underlying predispositions, surgical excision or debridement, and optimal antifungal therapy are some of the crucial factors in combating these fungal infections. This article provides a comparative review of literature on various fungal infections during COVID-19, that have been threatening worldwide, predominantly in India. A well-established databases literature search was conducted.

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Aspergillus-related lung disease in people with cystic fibrosis: can imaging help us to diagnose disease?

Cited by 9 publications

References 129 publications

Suppression of Aspergillus fumigatus Germination by Neutrophils Is Enhanced by Endothelial-Derived CSF3 Production

Suppression of Aspergillus fumigatus Germination by Neutrophils Is Enhanced by Endothelial-Derived CSF3 Production

A case‐control study of the effects of Aspergillus clinical phenotypes on pulmonary functions in patients with cystic fibrosis

A Comparative Overview of Various Fungal Menaces Amidst Corona Virus Disease

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