Astragalus Polysaccharide Enhances Voriconazole Metabolism under Inflammatory Conditions through the Gut Microbiota
Xiaokang Wang,
Xianjing Hu,
Chunxiao Ye
et al.
Abstract:Background and Aims
Voriconazole (VRC), a widely used antifungal drug, often causes hepatotoxicity, which presents a significant clinical challenge. Previous studies demonstrated that
Astragalus
polysaccharide (APS) can regulate VRC metabolism, thereby potentially mitigating its hepatotoxic effects. In this study, we aimed to explore the mechanism by which APS regulates VRC metabolism.
Methods
First, we assessed the association of abnormal VRC… Show more
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