2023
DOI: 10.1101/2023.10.18.562892
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Ataxia-telangiectasia mutated(Atm) disruption sensitizes spatially-directed H3.3K27M/TP53 diffuse midline gliomas to radiation therapy

Avani Mangoli,
Sophie Wu,
Harrison Q. Liu
et al.

Abstract: Diffuse midline gliomas (DMGs) are lethal brain tumors characterized by p53-inactivating mutations and oncohistone H3.3K27M mutations that rewire the cellular response to genotoxic stress, which presents therapeutic opportunities. We used RCAS/tv-a retroviruses and Cre recombinase to inactivate p53 and induce K27M in the native H3f3a allele in a lineage- and spatially-directed manner, yielding primary mouse DMGs. Genetic or pharmacologic disruption of the DNA damage response kinase Ataxia-telangiectasia mutate… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 46 publications
(125 reference statements)
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?