<i>Atriplex halimus</i>aqueous extract abrogates carbon tetrachloride-induced hepatotoxicity by modulating biochemical and histological changes in rats

Slama, Kheira; Boumendjel, Mahieddine; Taibi, Faiza; Boumendjel, Amel; Messarah, Mahfoud

doi:10.1080/13813455.2018.1489852

Cited by 21 publications

(25 citation statements)

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“…Also, the administration of olive oil was reported to improve principal parameters of oxidative stress, histopathological alterations and enzymatic indicators of hepatic injury [36]. These results are in accordance with the previous studies which reported the aqueous extract of A. halimus and J. phoenicea abrogates the CCl 4 -induced hepatotoxicity by modulating biochemical, antioxidant and histological changes [37,38].…”

Section: Discussionsupporting

confidence: 88%

Antioxidant, anti-inflammatory and hepatoprotective effects of olive fruit pulp extract: in vivo and in vitro study

Almatroodi

Almatroudi

Anwar

et al. 2020

Journal of Taibah University for Science

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Section: Discussionsupporting

confidence: 88%

Antioxidant, anti-inflammatory and hepatoprotective effects of olive fruit pulp extract: in vivo and in vitro study

Almatroodi

Almatroudi

Anwar

et al. 2020

Journal of Taibah University for Science

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“…18 NF-κB acts as a key transcriptional factor which can induce the expression of many other inflammatory genes, and thus modulates several steps in the inflammatory pathway. 24,40 It has been demonstrated that CCl 4intoxication results in the activation of liver macrophages 44 with the subsequent production of proinflammatory mediators including TNF-α which in turn exaggerate the CCl 4 -induced hepatic injury. 45,46 Furthermore, CCl 4 -induced free radicals lead to the activation of NF-κB and the release of inflammatory mediators into injured livers.…”

Section: Discussionmentioning

confidence: 99%

“…Group II (CCl 4 ) rats received the vehicle daily via gavage and a single CCl 4 dose was injected intraperitoneally (1 ml kg −1 of 1 : 1 v/v CCl 4 : olive oil) on the fifth day. 24 Groups III, IV, V, and VI (RK + CCl 4 ) received an oral administration of 25, 50, 100, and 200 mg kg −1 RK daily for 5 days via an oral tube, 12 respectively, and were injected intraperitoneally with a single dose of CCl 4 (1 ml kg −1 of 1 : 1 v/v CCl 4 : olive oil) on the fifth day of the experiment, 1 h after the administration of the last RK dose.…”

Section: Experimental Designmentioning

confidence: 99%

“…Hepatoprotective effects of RK (200 mg kg −1 ): Twenty-four adult male rats were divided into four groups: Group I rats (Control) received a vehicle daily via gavage and were injected intraperitoneally with a single dose of olive oil on the fifth day of the experiment. Group II (CCl 4 ) rats received the vehicle daily via gavage, and a single CCl 4 dose was injected intraperitoneally (1 mL kg −1 of 1 : 1 v/v CCl 4 : olive oil) on the fifth day (Slama et al, 2018). 24 Group III rats (RK: 200 mg kg −1 + CCl 4 ) received an oral administration of 200 mg kg −1 RK daily for 5 days via an oral tube and were injected intraperitoneally with a single dose of CCl 4 (1 mL kg −1 of 1 : 1 v/v CCl 4 : olive oil) on the fifth day of the experiment, 1 h after RK administration.…”

Section: Experimental Designmentioning

confidence: 99%

“…Group II (CCl 4 ) rats received the vehicle daily via gavage, and a single CCl 4 dose was injected intraperitoneally (1 mL kg −1 of 1 : 1 v/v CCl 4 : olive oil) on the fifth day (Slama et al, 2018). 24 Group III rats (RK: 200 mg kg −1 + CCl 4 ) received an oral administration of 200 mg kg −1 RK daily for 5 days via an oral tube and were injected intraperitoneally with a single dose of CCl 4 (1 mL kg −1 of 1 : 1 v/v CCl 4 : olive oil) on the fifth day of the experiment, 1 h after RK administration. Group IV (RK control: received an oral administration of 200 mg kg −1 RK daily for 5 days via oral tube and were injected intraperitoneally with a single dose of olive oil on the fifth day of the experiment; 1 h after the RK administration.…”

Section: Experimental Designmentioning

confidence: 99%

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Hepatoprotective activity of raspberry ketone is mediated via inhibition of the NF-κB/TNF-α/caspase axis and mitochondrial apoptosis in chemically induced acute liver injury

Fouad

Badr

Attia

2019

Toxicology Research

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Raspberry Ketone (RK) is a natural phenolic compound which is marketed nowadays as a popular weight-reducing remedy, with reported antioxidant and anti-inflammatory activities. However, its biological activity is not fully elucidated. Hepatotoxicity is the leading cause of acute liver failure in Europe and North America, and its management is still challenging. Therefore, this study aimed to assess the therapeutic detoxification activity of RK against liver injury in vivo and to explore the underlying mechanisms using carbon tetrachloride (CCl4)-induced hepatotoxicity as a model. First, a dose–response study using 4 different doses, 25, 50, 100, and 200 mg kg−1 day−1, of RK was conducted. RK was administered for 5 days as a pretreatment, followed by a single dose of CCl4 (1 ml kg−1, 1 : 1 v/v CCl4 : olive oil). The RK dose of 200 mg kg−1 showed the greatest protective effect and was selected for further investigations. CCl4 hepatotoxicity was confirmed by elevation of liver enzymes, and histopathological examination. CCl4-induced oxidative stress was evident from increased lipid peroxidation measured as thiobarbituric acid reactive substances (TBARS) along with depleted superoxide dismutase (SOD), reduced glutathione (GSH), and total antioxidant capacity (TAC). Increased oxidative stress was associated with increased cytochrome c expression with subsequent activation of caspase-9 and caspase-3, in addition to DNA fragmentation reflecting apoptosis. CCl4 also induced the expression of inflammatory cytokines (NF-κB and TNF-α). Interestingly, RK hepatoprotective activity was evident from the reduction of liver enzymes, and maintenance of hepatocyte integrity and microstructures as evaluated by histopathological examination using H and E, and transmission electron microscopy. The antioxidant activity of RK was demonstrated by the increase of TAC, SOD, and GSH, with a concomitant decrease of the TBARS level. Moreover, RK pretreatment inhibited CCl4-induced upregulation of inflammatory mediators. RK antiapoptotic activity was indicated by the reduction of the expression of cytoplasmic cytochrome-C, a decrease of caspases, and inhibition of DNA fragmentation. In conclusion, this study demonstrates that RK is a promising hepatoprotective agent. The underlying mechanisms include antioxidant, anti-inflammatory, and anti-apoptotic activities. This is the first study reporting RK hepatoprotective activity in acute hepatic injury and approves its antiapoptotic effect in the liver.

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Potential Hepatoprotective Effect of Matricaria Pubescens on High‐Fat Diet‐Induced Non‐Alcoholic Fatty Liver Disease in Rats

Chenna,

Khelef,

Halimi

et al. 2024

Chemistry & Biodiversity

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This study aimed to identify the phytochemical compounds of Matricaria pubescens by LC–MS/MS and evaluate the potential protective effect of its supplementation in high‐fat diet (HFD)‐induced non‐alcoholic fatty liver disease (NAFLD) in adult rats through modulation of oxidative stress and histopathological changes. Twenty‐four male rats were randomly divided into four groups. The first group served as control and received the standard diet. The second group (HFD) received a high‐fat diet only (30 % of sheep fat). The third group‘s (control+MP) animals received a standard diet supplemented with 5 % M. pubescens (w/w). The fourth group (HFD+MP) received a high‐fat diet supplemented with 5 % M. pubescens for 16 weeks. LC–MS/MS analysis showed that M. pubescens contains many phytochemical compounds. It was observed that the ethanolic extract of M. pubescens has a higher phenolic content than the aqueous extract. The supplementation of M. pubescens (5 % w/w) to HFD rats decreased significantly (p<0.01) body weight, liver and epididymal adipose tissue relative weights, glycemia, triglycerides (TG), insulin resistance, liver markers, TNF‐α, malondialdehyde (MDA), protein carbonyl (PCO), advanced oxidation protein products (AOPP) level, and increased reduced glutathione (GSH) level, glutathione peroxidase (GPx), glutathione‐S‐transferase (GST), superoxide dismutase (SOD), and catalase activities as well as ameliorated histological alterations through the reduction hepatic lipid deposition and adipocytes hypertrophy compared to the HFD group. We conclude that M. pubescens powder may be effective for correcting hyperglycemia, hypertriglyceridemia, insulin resistance, and liver markers while decreasing inflammation and oxidative stress in the liver of high‐fat diet‐fed rats.

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Atriplex halimusaqueous extract abrogates carbon tetrachloride-induced hepatotoxicity by modulating biochemical and histological changes in rats

Cited by 21 publications

References 56 publications

Antioxidant, anti-inflammatory and hepatoprotective effects of olive fruit pulp extract: in vivo and in vitro study

Antioxidant, anti-inflammatory and hepatoprotective effects of olive fruit pulp extract: in vivo and in vitro study

Hepatoprotective activity of raspberry ketone is mediated via inhibition of the NF-κB/TNF-α/caspase axis and mitochondrial apoptosis in chemically induced acute liver injury

Potential Hepatoprotective Effect of Matricaria Pubescens on High‐Fat Diet‐Induced Non‐Alcoholic Fatty Liver Disease in Rats

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