Baccharis dracunculifoliamethanol extract enhances glucose-stimulated insulin secretion in pancreatic islets of monosodium glutamate induced-obesity model rats

Abstract

Treatment with B. dracunculifolia extracts protected pancreatic islets and prevented the irreversible cellular damage observed in animals in obesity and diabetes models.

Polyphenol-Rich Extract of Syzygium cumini Leaf Dually Improves Peripheral Insulin Sensitivity and Pancreatic Islet Function in Monosodium L-Glutamate-Induced Obese Rats

“…Although we did not measure circulating levels of free fatty acids, a limitation in this report, obese+HESc rats showed strong decrease of triglyceride levels ( Figure 5B ; Table 2 ), which may lead to lower GPR40 activation and consequent decrease of insulin secretion. Our data are further supported by recent findings that methanol extract of Baccharis dracunculifolia (400 mg/Kg/day, 30 days) decreased serum insulin levels in MSG-obese rats subsequent to improved peripheral insulin sensitivity ( Hocayen et al, 2015 ), in spite of insulin oversecretion caused by high parasympathetic activity on pancreatic islets of MSG-obese rodents ( Miranda et al, 2014 ). Authors attributed this effect to the high antioxidant capacity of the extract ( Hocayen et al, 2015 ), a property well-demonstrated by HESc.…”

“…For instance, catechin-derivatives like ( epi )gallocatechin-( epi )gallocatechin- O -gallate, which is present in our HESc extract ( Table 1 ), were shown to promote insulin secretion by improving β-cell mitochondrial function, in addition to other effects like antioxidant, antiinflammatory, and glucotoxicity prevention ( Cai and Lin, 2009 ). Nevertheless, HESc-treated obese rats had reduced serum insulin levels ( Figure 6E ), in spite of a higher ex vivo insulin release response under hyperglycemic conditions ( Figure 7A ), very similar to the effects of Baccharis dracunculifolia methanol extract on MSG-obese rats ( Hocayen et al, 2015 ). This particular set of data is suggestive of a role for HESc as an activator of peripheral pathways evoked either by recovery of peripheral insulin sensitivity ( Figure 6F ), or by lowering of serum lipids ( Figure 5 ), which may promote decreased in vivo insulin release in our obese+HESc rats.…”

Daidzin decreases blood glucose and lipid in streptozotocin-induced diabetic mice

“…There are many approaches to efficiently decrease blood glucose level such as promoting insulin secretion [24], inhibiting glucose absorption [25], stimulating glucose uptake by tissues [26] and increasing insulin sensitivity [27]. Insulinotropic agents such as glibenclamide, stimulate insulin secretion and dramatically decrease blood glucose level in both normal and diabetic animals.…”

Encapsulated Microparticles of (1→6)-β-d-Glucan Containing Extract of Baccharis dracunculifolia: Production and Characterization

“…Baccharis dracunculifolia , popularly known in Brazil as alecrim-do-campo (field rosemary) or vassourinha do campo, is a medicinal plant used to treat human disease conditions and from which green propolis is produced by honeybees [5,6,7]. Several biological properties related to B. dracunculifolia , including antidiabetic [8], anti-inflammatory [7], bactericidal [9], and antioxidant [10] activities, have been reported in the scientific literature.…”