<i>Bacopa monniera</i> extract mitigates isoproterenol-induced cardiac stress via Nrf2/Keap1/NQO1 mediated pathway

Manu, T. Mohan; Anand, T.; Babu, G R Sharath; Patil, M. M.; Khanum, Farhath

doi:10.1080/13813455.2019.1683583

Cited by 6 publications

(5 citation statements)

References 53 publications

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“…"Reactive oxygen species (ROS) induce lipid peroxidation, promote malondialdehyde (MDA) formation, and contribute to the release of proapoptotic factors from mitochondria" [24]. "It has been confirmed that isoprenaline (ISO), a non-selective synthetic agonist of beta-adrenergic receptors, induces MI at high doses (85 -340 mg/kg) in the rat" [25,26] which causes an imbalance between the production of free radicals and antioxidants and antioxidants. ISO-induced IM is documented in numerous studies in laboratory animals with properties similar to those of humans.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Role of Caralluma indica Stem Extract in Isoproterenol Induced Oxidative Stress in Albino Rats

Vadivu,

Velavan

2023

UPJOZ

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Plants are important for human life on earth and serve as the food. Another important aspect of the plant is therapeutic use. Medicinal plants afford a best source of active compounds to find new medicines that have no adverse effects, such as those that are a very respectable source of disease treatment, that are associated with oxidative stress. Oxidative stress plays a significant role in the pathogenesis of a myocardial infarction (MI) and has been well recognized in the properties of isoproteinol-induced MI. Current research aims to investigate the role of antioxidants in the Caralluma indica stem extract (CISE) in isoproterenol -induced oxidative stress in albino rats. Depending on the results achieved, CISE can be a suitable candidate to reduce the oxidative stress induced by isoproterenol. CISE management shows an increase in antioxidant status in the treatment of isoproterenol as follows. The cardioprotective properties of CISE can be attributed to the antioxidant components of CISE. Graphical abstract of antioxidant role of Caralluma indica stem extract

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Section: Discussionmentioning

confidence: 99%

Antioxidant Role of Caralluma indica Stem Extract in Isoproterenol Induced Oxidative Stress in Albino Rats

Vadivu,

Velavan

2023

UPJOZ

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“…Bacopa monnieri: B. monnieri has shown good results in maintaining cardiac rhythm and myocardial integrity and decreasing oxidative stress by strengthening the endogenous defense system through Nrf2 modulation 25 . Additionally, B. monnieri has been shown to increase coronary flow by 63% (30 g/ml) and 216% (100 g/ml), compared to control (5%) making it the perfect treatment for ischemia/reperfusion injury.…”

Section: Glycyrrhiza Glabramentioning

confidence: 99%

Untitled

2023

IJPSR

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Cardiovascular diseases (CVDs) are related to heart and blood vessel disorders. The changing lifestyles of unhealthy diets, physical inactivity, and tobacco and alcohol consumption have increased the risk factors of heart diseases. A literature search reveals that the rise in risk of CVD's is higher after a SARS-COV2 infection. Also, CVDs independently are one of the leading cause of death globally. There is hence a need of research of new molecules with improved therapeutics. Herbal medications have been utilized to treat cardiovascular diseases for many years around the world. The advancement of herbal nanotechnology in the field of CVDs has been shown to have astounding benefits over herbal crude drug formulations or herbal extracts, including better solubility, bioavailability, toxicity protection, pharmacological activity augmentation, dose reduction, and stability. This paper discusses the traditional herbal drugs and the herbal formulations, specifically herbal nanoparticles (NPs), for the treatment of CVDs and their advantages. INTRODUCTION:CVDs are the biggest cause of death worldwide and are expected to continue to be so. Coronavirus disease 2019 (COVID-19), caused by a coronavirus strain known as SARS-CoV-2, has spread worldwide, affecting billions of people. COVID-19 and cardiovascular disease appear to be linked, according to research. Patients with COVID-19 with pre-existing cardiovascular illness had the worst results and were more likely to die, whereas COVID-19 can also cause myocardial damage, arrhythmia, acute coronary syndrome, and venous thromboembolism, which has become a severe concern 1 .

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“…The experimental studies from Table 1 demonstrated that modulating natural products via Nrf2 pathways exerts beneficial antioxidant and anti-inflammatory effects [ 132 , 137 , 140 ] in severe heart failure [ 133 ], in radiation-induced OS [ 134 ], in induced-cardiac stress [ 136 ], in renal impairment [ 139 ], in atherosclerosis [ 142 ], and in ochratoxin-induced toxicity [ 143 ] and also shows cytoprotective and antimicrobial properties [ 135 ]; cytoprotective and cancer chemopreventive effects [ 138 ]; and anti-inflammatory, antioxidant, hepatoprotective, neuroprotective, cardioprotective, renoprotective, antiobesity, antidiabetic, and anticancer effects [ 141 ] in other chronic diseases. Although the studies mentioned did not directly explore the effect of natural products in hypertension, the administration of these natural products leads to an Nrf2 response with subsequent activation of various protective pathways which can be linked to vascular protection.…”

Section: Therapeutic Options In Htnmentioning

confidence: 99%

Oxidative Stress in Arterial Hypertension (HTN): The Nuclear Factor Erythroid Factor 2-Related Factor 2 (Nrf2) Pathway, Implications and Future Perspectives

et al. 2022

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Arterial hypertension (HTN) is one of the most prevalent entities globally, characterized by increased incidence and heterogeneous pathophysiology. Among possible etiologies, oxidative stress (OS) is currently extensively studied, with emerging evidence showing its involvement in endothelial dysfunction and in different cardiovascular diseases (CVD) such as HTN, as well as its potential as a therapeutic target. While there is a clear physiological equilibrium between reactive oxygen species (ROS) and antioxidants essential for many cellular functions, excessive levels of ROS lead to vascular cell impairment with decreased nitric oxide (NO) availability and vasoconstriction, which promotes HTN. On the other hand, transcription factors such as nuclear factor erythroid factor 2-related factor 2 (Nrf2) mediate antioxidant response pathways and maintain cellular reduction–oxidation homeostasis, exerting protective effects. In this review, we describe the relationship between OS and hypertension-induced endothelial dysfunction and the involvement and therapeutic potential of Nrf2 in HTN.

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Bacopa monniera extract mitigates isoproterenol-induced cardiac stress via Nrf2/Keap1/NQO1 mediated pathway

Cited by 6 publications

References 53 publications

Antioxidant Role of Caralluma indica Stem Extract in Isoproterenol Induced Oxidative Stress in Albino Rats

Antioxidant Role of Caralluma indica Stem Extract in Isoproterenol Induced Oxidative Stress in Albino Rats

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Oxidative Stress in Arterial Hypertension (HTN): The Nuclear Factor Erythroid Factor 2-Related Factor 2 (Nrf2) Pathway, Implications and Future Perspectives

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