<i>Bacteroides uniformis</i>
            and its preferred substrate, α-cyclodextrin, enhance endurance exercise performance in mice and human males

Morita, Hiroto; Kano, Chie; Ishii, Chiharu; Kagata, Noriko; Ishikawa, Takamasa; Hirayama, Akiyoshi; Uchiyama, Yoshihide; Hara, Shotaro; Nakamura, T.; Fukuda, Shinji

doi:10.1126/sciadv.add2120

Cited by 31 publications

(20 citation statements)

References 70 publications

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“…Deconditioning and reconditioning periods affected relative abundance of the Bacteroidetes phylum in this study. A greater abundance of Bacteroidetes has been reported in lean or aerobically trained humans (Morita et al., 2023 ; Motiani et al., 2020 ) and animals (Evans et al., 2014 ). Correspondingly, we observed a decrease and an increase in some of the Bacteroidetes OTUs following deconditioning and reconditioning, respectively.…”

Section: Discussionmentioning

confidence: 94%

Effects of astaxanthin on gut microbiota of polo ponies during deconditioning and reconditioning periods

Kawaida,

Maas,

Moore

et al. 2024

Physiological Reports

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To determine the effects of astaxanthin (ASTX) supplementation on the equine gut microbiota during a deconditioning–reconditioning cycle, 12 polo ponies were assigned to a control (CON; n = 6) or supplemented (ASTX; 75 mg ASTX daily orally; n = 6) group. All horses underwent a 16‐week deconditioning period, with no forced exercise, followed by a 16‐week reconditioning program where physical activity gradually increased. Fecal samples were obtained at the beginning of the study (Baseline), after deconditioning (PostDecon), after reconditioning (PostRecon), and 16 weeks after the cessation of ASTX supplementation (Washout). Following DNA extraction from fecal samples, v4 of 16S was amplified and sequenced to determine operational taxonomic unit tables and α‐diversity and β‐diversity indices. The total number of observed species was greater at Baseline than PostDecon, PostRecon, and Washout (p ≤ 0.02). A main effect of ASTX (p = 0.01) and timepoint (p = 0.01) was observed on β‐diversity, yet the variability of timepoint was greater (13%) than ASTX (6%), indicating a greater effect of timepoint than ASTX. Deconditioning and reconditioning periods affected the abundance of the Bacteroidetes and Fibrobacteres phyla. Physical activity and ASTX supplementation affect the equine gut microbiome, yet conditioning status may have a greater impact.

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Section: Discussionmentioning

confidence: 94%

Effects of astaxanthin on gut microbiota of polo ponies during deconditioning and reconditioning periods

Kawaida,

Maas,

Moore

et al. 2024

Physiological Reports

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“…The most significant discrepancy was noted for Bacteroides uniformis , which drastically decreased in abundance in the low-power group and increased in the high-power group. Bacteroides uniformis facilitates glucose production and enhances physical performance [ 59 ]. Roseburia inulinivorans showed the highest sensitivity with regards to VO 2 max, with a slightly more significant decrease in the low group than in the high group.…”

Section: Resultsmentioning

confidence: 99%

Microbiome features associated with performance measures in athletic and non-athletic individuals: A case-control study

Humińska-Lisowska,

Zielińska,

Mieszkowski

et al. 2024

PLoS ONE

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The influence of human gut microbiota on health and disease is now commonly appreciated. Therefore, it is not surprising that microbiome research has found interest in the sports community, hoping to improve health and optimize performance. Comparative studies found new species or pathways that were more enriched in elites than sedentary controls. In addition, sport-specific and performance-level-specific microbiome features have been identified. However, the results remain inconclusive and indicate the need for further assessment. In this case-control study, we tested two athletic populations (i.e. strength athletes, endurance athletes) and a non-athletic, but physically active, control group across two acute exercise bouts, separated by a 2-week period, that measured explosive and high intensity fitness level (repeated 30-s all-out Wingate test (WT)) and cardiorespiratory fitness level (Bruce Treadmill Test). While we did not identify any group differences in alpha and beta diversity or significant differential abundance of microbiome components at baseline, one-third of the species identified were unique to each group. Longitudinal sample (pre- and post-exercise) analysis revealed an abundance of Alistipes communis in the strength group during the WT and 88 species with notable between-group differences during the Bruce Test. SparCC recognized Bifidobacterium longum and Bifidobacterium adolescentis, short-chain fatty acid producers with probiotic properties, species strongly associated with VO2max. Ultimately, we identified several taxa with different baseline abundances and longitudinal changes when comparing individuals based on their VO2max, average power, and maximal power parameters. Our results confirmed that the health status of individuals are consistent with assumptions about microbiome health. Furthermore, our findings indicate that microbiome features are associated with better performance previously identified in elite athletes.

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“…35 Additionally, a study of Japanese longdistance runners found an association between Bacteroides uniformis and endurance exercise performance, with α-cyclodextrin supplementation increasing B. uniformis and improving endurance exercise performance. 36 Moreover, Bacteroides plebeius has been reported to inhibit chronic kidney disease-induced muscle atrophy in animal models. 37 These findings may suggest a beneficial association between the Bacteroides genus and sarcopenia and skeletal muscle phenotypes.…”

Section: Discussionmentioning

confidence: 99%

“…An aerobic exercise training intervention for older Japanese women increased the relative abundance of Bacteroides and was positively correlated with walking performance 35 . Additionally, a study of Japanese long‐distance runners found an association between Bacteroides uniformis and endurance exercise performance, with α‐cyclodextrin supplementation increasing B. uniformis and improving endurance exercise performance 36 . Moreover, Bacteroides plebeius has been reported to inhibit chronic kidney disease–induced muscle atrophy in animal models 37 .…”

Section: Discussionmentioning

confidence: 99%

Association of skeletal muscle function, quantity, and quality with gut microbiota in Japanese adults: A cross‐sectional study

Iwasaka,

Nanri,

Nakagata

et al. 2023

Geriatrics Gerontology Int

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AimThe gut microbiota has emerged as a new intervention target for sarcopenia. Prior studies in humans have focused on the association between gut microbiota and skeletal muscle quantity, while the evidence on muscle function and quality is lacking. This study aimed to identify gut microbiota genera associated with skeletal muscle function, quantity, and quality in a general population of Japanese adults.MethodsThis cross‐sectional study included 164 participants aged 35–80 years, women and men recruited from urban areas of Japan. Fecal samples were collected and analyzed using 16S rRNA gene amplicon sequencing. Skeletal muscle function was measured using handgrip strength and leg extension power (LEP), while skeletal muscle mass was estimated using bioelectrical impedance analysis. Phase angle was used as a measure of skeletal muscle quality. Multivariate linear regression analysis stratified by age group was used to examine the association between the dominant genera of the gut microbiota and skeletal muscle variables.ResultsA significant association was found between Bacteroides and Prevotella 9 with LEP only in the ≥60 years group. When both Bacteroides and Prevotella 9 were included in the same regression model, only Bacteroides remained consistently and significantly associated with LEP. No significant associations were observed between skeletal muscle mass, handgrip strength, and phase angle and major gut microbiota genera.ConclusionsIn this study, we observed a significant positive association between Bacteroides and leg muscle function in older adults. Further studies are required to elucidate the underlying mechanisms linking Bacteroides to lower‐extremity muscle function. Geriatr Gerontol Int 2024; 24: 53–60.

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Bacteroides uniformis and its preferred substrate, α-cyclodextrin, enhance endurance exercise performance in mice and human males

Cited by 31 publications

References 70 publications

Effects of astaxanthin on gut microbiota of polo ponies during deconditioning and reconditioning periods

Effects of astaxanthin on gut microbiota of polo ponies during deconditioning and reconditioning periods

Microbiome features associated with performance measures in athletic and non-athletic individuals: A case-control study

Association of skeletal muscle function, quantity, and quality with gut microbiota in Japanese adults: A cross‐sectional study

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