Bacteroides uniformis combined with fiber amplifies metabolic and immune benefits in obese mice

Abstract

Gut microbiota represents a therapeutic target for obesity. We hypothesize that B. uniformis CECT 7771 combined with wheat bran extract (WBE), its preferred carbon source, may exert superior anti-obesity effects. We performed a 17-week intervention in diet-induced obese mice receiving either B. uniformis , WBE, or their combination to identify interactions and independent actions on metabolism and immunity. B. uniformis combined with WBE was the most effective intervention, curbing weight gain and adiposity, while exerting more modest effects separately. The combination restored insulin-dependent metabolic routes in fat and liver, although the bacterium was the primary driver for improving whole-body glucose disposal. Moreover, B. uniformis -combined with WBE caused the highest increases in butyrate and restored the proportion of induced intraepithelial lymphocytes and type-3 innate lymphoid cells in the intestinal epithelium. Thus, strengthening the first line of immune defense against unhealthy diets and associated dysbiosis in the intestine. This intervention also attenuated the altered IL22 signaling and liver inflammation. Our study shows opportunities for employing B. uniformis , combined with WBE, to aid in the treatment of obesity.

Variations in Gut Microbiome are Associated with Prognosis of Hypertriglyceridemia-Associated Acute Pancreatitis

“…These results suggested that the decrease in gut microflora which produced SCFAs may be responsible for the poor outcome of HTGAP patients. Some Bacteroides species within the family Bacteroidaceae , including Bacteroides ovatus , Bacteroides xylanisolvens , and Bacteroides uniformis , were essential species to induce the production of gut IgA, which acted as a protective factor for maintaining the stability of the intestinal environment by limiting the bacteria and endotoxin invasive intestinal epithelial cells, facilitating bacterial clearance, and regulating bacterial colonization [ 48 , 49 , 50 ].…”

Protective effects of different Bacteroides vulgatus strains against lipopolysaccharide-induced acute intestinal injury, and their underlying functional genes

“…The roles of different Bacteroides species in alleviating diseases have been demonstrated in a series of studies, including inhibiting tumor [13] , protecting against colitis [14] , alleviating obesity [15] , preventing atherosclerosis [16] , etc. Interestingly, different species of Bacteroides regulated the human health and diseases through different mechanisms.…”

The Synbiotic Combination of Akkermansia muciniphila and Quercetin Ameliorates Early Obesity and NAFLD through Gut Microbiota Reshaping and Bile Acid Metabolism Modulation

“…Nevertheless, obesity-related NAFLD patients, especially children, usually have a low adherence to these type of interventions, and it is necessary to search for new strategies in the treatment of these pathologies [ 11 , 12 ]. Thus, due to the role of gut microbiota alterations in the development of NAFLD and obesity, the administration of prebiotics or probiotics are feasible therapies in the management of these diseases, and the combination of both, namely synbiotics, may potentiate the efficacy of the intervention [ 13 , 14 ]. In fact, the flavonoid quercetin has been reported to counteract NAFLD in in vivo models through a possible prebiotic effect, besides its antioxidant and anti-inflammatory properties [ 7 , 15 ].…”