Balanophora spicataand Lupeol Acetate Possess Antinociceptive and Anti-Inflammatory ActivitiesIn VivoandIn Vitro

Chen, Yuh Fung; Ma, Chien‐Ching; Wu, Tian Shung; Wu, Chi‐Rei; Hsieh, Wen Tsong; Tsai, Huei Yann

doi:10.1155/2012/371273

Cited by 30 publications

(28 citation statements)

References 15 publications

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“…Lupeol acetate has been reported to significantly reduce NO production, inducible nitric oxide synthase (iNOS) protein levels, and lipopolysaccharide- (LPS-) induced cyclooxygenase- (COX-) 2 expression, showing antinociceptive and anti-inflammatory activities [63]. In another animal study, the lupeol also presented antinociceptive properties during inflammatory pain, inhibiting interleukin- (IL-) 1 β and tumor necrosis factor- (TNF-) α production induced by carrageenan [64].…”

Section: Discussionmentioning

confidence: 99%

Neurobehavioral and Antioxidant Effects of Ethanolic Extract of Yellow Propolis

Silveira

Fernandes

Silva

et al. 2016

Oxidative Medicine and Cellular Longevity

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Propolis is a resin produced by bees from raw material collected from plants, salivary secretions, and beeswax. New therapeutic properties for the Central Nervous System have emerged. We explored the neurobehavioral and antioxidant effects of an ethanolic extract of yellow propolis (EEYP) rich in triterpenoids, primarily lupeol and β-amyrin. Male Wistar rats, 3 months old, were intraperitoneally treated with Tween 5% (control), EEYP (1, 3, 10, and 30 mg/kg), or diazepam, fluoxetine, and caffeine (positive controls) 30 min before the assays. Animals were submitted to open field, elevated plus maze, forced swimming, and inhibitory avoidance tests. After behavioral tasks, blood samples were collected through intracardiac pathway, to evaluate the oxidative balance. The results obtained in the open field and in the elevated plus maze assay showed spontaneous locomotion preserved and anxiolytic-like activity. In the forced swimming test, EEYP demonstrated antidepressant-like activity. In the inhibitory avoidance test, EEYP showed mnemonic activity at 30 mg/kg. In the evaluation of oxidative biochemistry, the extract reduced the production of nitric oxide and malondialdehyde without changing level of total antioxidant, catalase, and superoxide dismutase, induced by behavioral stress. Our results highlight that EEYP emerges as a promising anxiolytic, antidepressant, mnemonic, and antioxidant natural product.

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Section: Discussionmentioning

confidence: 99%

Neurobehavioral and Antioxidant Effects of Ethanolic Extract of Yellow Propolis

Silveira

Fernandes

Silva

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…In the seeds, the terpenoids detected using gas chromatography were β -sitosterol, stigmasterol, lupeol, campesterol, and squalene [14, 15]. Interestingly, lupeol was found to possess anticarcinogenic [16], antinociceptive, and anti-inflammatory properties [17]. No flavonoid like quercetin, myricetin, luteolin, kaempferol, or apigenin was detected in the methanolic extract of P. speciosa seeds using a reversed-phase high performance liquid chromatography [18], but it was noted to be present in the ethanolic extract when screened using a colorimetric assay [10].…”

Section: Chemical Compoundsmentioning

confidence: 99%

Parkia speciosaHassk.: A Potential Phytomedicine

Kamisah

Othman

Qodriyah

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Parkia speciosa Hassk., or stink bean, is a plant indigenous to Southeast Asia. It is consumed either raw or cooked. It has been used in folk medicine to treat diabetes, hypertension, and kidney problems. It contains minerals and vitamins. It displays many beneficial properties. Its extracts from the empty pods and seeds have a high content of total polyphenol, phytosterol, and flavonoids. It demonstrates a good antioxidant activity. Its hypoglycemic effect is reported to be attributable to the presence of β-sitosterol, stigmasterol, and stigmast-4-en-3-one. The cyclic polysulfide compounds exhibit antibacterial activity, while thiazolidine-4-carboxylic acid possesses anticancer property. The pharmacological properties of the plant extract are described in this review. With ongoing research conducted on the plant extracts, Parkia speciosa has a potential to be developed as a phytomedicine.

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“…It is noteworthy to report its isolation for the first time from this plant, Chrysophyllum albidum. The compound was reported to possess anti-fertility (Gupta et al, 2005), anti-inflammatory (Lucetti et al, 2010;Chen et al, 2012), anti-nociceptive (Chen et al, 2012), anti-arthritic (Kweifio-Okai and Caroll, 1993), anti-venom (Chatterjee et al, 2006) and anti-diabetic (Lakshmi et al, 2014;Fredjaiyesimi and Ibukunoluwa, 2016) properties. The presence of lupeol-3-acetate appears to account for the hyperglycaemia lowering activity of dichloromethane fraction.…”

Section: Resultsmentioning

confidence: 99%

The isolation and characterization of lupeol-3-acetate from the hyperglycaemia-lowering fraction of the stem bark of Crystophyllum albidum G. Don (Sapotaceae)

Olanudun¹,

Ayoola²,

Famuyiwa³

2018

Ife Journal of Science

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This study investigated the hyperglycaemia-lowering activity of the extract and partitioned fractions of the stem bark of Chrysophyllum albidum, and isolation of a bio-active compound from the most active fraction. Powdered stem bark of the plant was extracted with methanol and the extract (A) was tested in glucose-induced hyperglycaemic rats at 100, 200 and 400 mg/kg. The extract was partitioned to obtain its n-hexane (B), 1 dichloromethane (B), ethyl acetate (B) and mother liquor (B) fractions that were tested for blood glucose 2 3 4 lowering activity using glucose-induced hyperglycaemic model at the most active dose of the extract. The results were subjected to ANOVA followed by Student-Newman-Keuls post hoc tests and p< 0.05 was considered significant. The extract (A) gave dose dependent activity with 400 mg/kg giving the highest percentage blood glucose level reduction of 13% at 4 h that was comparable to the standard, glibenclamide at 5 mg/kg. Fractions B and B gave a time-dependent activity up to the fourth hour similar to glibenclamide, while B and B were 1 2 3 4 devoid of hyperglycaemia-lowering activity. Furthermore, B gave 3, 18, 19 and 29% blood glucose levels 1 reduction at 0.5, 1, 2 and 4 h respectively while B gave 12, 28, 33 and 41% blood glucose levels reduction at 0.5, 1, 2 2 and 4 h respectively. The activity of B was significantly (p<0.05) more active than glibenclamide at all-time 2 point. The dichloromethane fraction (B), most active, was subjected to column and preparative thin layer 2 chromatography and the fraction afforded lupeol-3-acetate. The structure was validated by using Bruker Ascend 400 NMR instrument and the NMR data was compared with literature. The compound was one of the compounds responsible for the biological activity observed as reported by Lakshmi and his co-workers, 2014.

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Balanophora spicataand Lupeol Acetate Possess Antinociceptive and Anti-Inflammatory ActivitiesIn VivoandIn Vitro

Cited by 30 publications

References 15 publications

Neurobehavioral and Antioxidant Effects of Ethanolic Extract of Yellow Propolis

Neurobehavioral and Antioxidant Effects of Ethanolic Extract of Yellow Propolis

Parkia speciosaHassk.: A Potential Phytomedicine

The isolation and characterization of lupeol-3-acetate from the hyperglycaemia-lowering fraction of the stem bark of <i>Crystophyllum albidum</i> G. Don (Sapotaceae)

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