<i>Bartonella henselae</i> Bloodstream Infection in a Boy With Pediatric Acute-Onset Neuropsychiatric Syndrome

Breitschwerdt, Edward B.; Greenberg, Rosalie; Maggi, Ricardo G.; Mozayeni, B. Robert; Lewis, A M; Bradley, Julie M.

doi:10.1177/1179573519832014

Cited by 38 publications

(42 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…36,37 In conjunction with the cases in this report, B henselae bacteremia may contribute to progressive, recalcitrant neuropsychiatric symptoms consistent with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) in a subset of patients and may be misdiagnosed as schizophrenia. 37 There is also evidence that Bartonella spp. infection may play a role in some cases of pediatric mood disorders.…”

Section: Discussionmentioning

confidence: 57%

“…There is increasing microbiologic evidence indicating bloodstream and cerebrospinal fluid infections with one or more Bartonella spp. in patients with neuropsychiatric symptoms 36,37 . In conjunction with the cases in this report, B henselae bacteremia may contribute to progressive, recalcitrant neuropsychiatric symptoms consistent with Pediatric Acute‐onset Neuropsychiatric Syndrome (PANS) in a subset of patients and may be misdiagnosed as schizophrenia 37 .…”

Section: Discussionmentioning

confidence: 58%

See 1 more Smart Citation

Imaging analysis of Bartonella species in the skin using single‐photon and multi‐photon (second harmonic generation) laser scanning microscopy

Maluki

Breitschwerdt

Bemis

et al. 2020

Clinical Case Reports

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 58%

Imaging analysis of Bartonella species in the skin using single‐photon and multi‐photon (second harmonic generation) laser scanning microscopy

Maluki

Breitschwerdt

Bemis

et al. 2020

Clinical Case Reports

Self Cite

View full text Add to dashboard Cite

show abstract

“…Therefore, these results suggest that immune activation in the brain during early-, mid-to late fetal development and adolescence to young adulthood is more likely to interfere with pathways related to synapse formation, structure and remodeling. Consistent with this speculation, accumulating evidence demonstrates that prenatal maternal infections during pregnancy 28,29 and infection events during adolescence are associated with schizophrenia 47,48 .…”

Section: Resultsmentioning

confidence: 72%

Systematic search for schizophrenia pathways sensitive to perturbation by immune activation

Gao

Liang

Ren

et al. 2019

Preprint

View full text Add to dashboard Cite

Immune activation has been recently found to play a large part in the development of schizophrenia, but the underlying mechanism remains largely unknown. Here, we report the construction of a high-quality protein interaction network for schizophrenia (SCZ Network) using a "neighborhood walking" approach to searching across human interactome network for disease-related neighborhoods. The spatiotemporal expression pattern of the immune genes in the SCZ Network demonstrates that this disease network is sensitive to the perturbation of immune activation during mid-to late fetal development and adolescence. The immune genes in the network are involved in pathways regulating the formation, structure and function of synapses and neural connections.Using single-cell transcriptome sequencing on the brains of immune-activated mice, we found that immune activation disturbed the SCZ network in the major brain cell types and the dysregulated pathways were also involved in synapse regulation, demonstrating that our "neighborhood walking" approach enables biological discovery in complex disorders. 1 in the selected neighborhoods for removing nodes from the candidate SCZ networks. Using on these optimal cutoffs, we obtained a SCZ Network, which has a seed ratio of 72.3% and contains 3,975 nodes and 92,318 edges, including 869 immune genes (658 known SCZ candidate genes) and 3,106 non-immune genes (2,215 known SCZ candidate genes) ( Fig. 1e, Supplementary Data 4). The high quality SCZ network.The primary purpose of our "neighborhood walking" approach is to extract a high-quality disease network from human interactome by removing false positives of SCZ candidate genes while keeping the true positives and novel candidate genes in the network. Of the 3,437 SCZ candidate genes, 3,265 were mapped on the human interactome ( Fig. 2a). After the "neighborhood walking" process, 2,873 schizophrenia candidate genes and 1,102 novel candidate genes were kept in the SCZ Network (Fig. 1e). In order to verify that the "neighborhood walking" approach has removed false positives and kept true positives, we evaluated the SCZ relevance of the kept genes (genes inside the SCZ Network) and removed genes (genes outside the SCZ Network) using three datasets collected from literature (Supplementary Data 5): (i) dysregulated genes in the brain of schizophrenia patients 39-42 , (ii) variants associated with schizophrenia 43 and (iii) genes with brain-specific expression (Expression Atlas) 44 . Compared to removed genes, the kept genes showed significant enrichment with dysregulated genes in the brains of schizophrenia patients (p = 0.0007 for all kept genes, two-side Fisher's exact tests) ( Fig. 2b, Supplementary Data 5), SCZ-associated variants (p = 5.9827e-98 for all kept genes, p = 7.5082e-07 for kept seeds, p = 0.0183 for kept nonseeds, two-side Fisher's exact tests) ( Fig. 2c, Supplementary Data 5), and brain-specific genes (p = 2.3283e-99 for all kept genes, p = 6.0824e-11 for kept nonseeds, two-side Fisher's exact tests) ( Fig. 2d, Supplementary Dat...

show abstract

“…A recent case study suggested a candidate infectious mechanism causal agent for schizophrenia may be the bacterium responsible for cat scratch disease (i.e., "cat scratch fever") -Bartonella henselae [23]. This study linked B. henselae seropositivity and a history of cat bites and scratches to onset of schizophrenia symptoms in a 14-year-old boy.…”

Section: Discussionmentioning

confidence: 83%

Childhood Cat Bites Relate to Increased Adulthood Severity of Schizotypy, Psychotic-Like Experiences, and Social Anhedonia in a Transdiagnostic Psychiatric Sample

Bedwell¹,

Spencer²

2020

Psychopathology

View full text Add to dashboard Cite

Introduction: Previous research has linked childhood cat scratches and bites to an increased risk for depression, and childhood cat ownership to increased risk of schizophrenia, bipolar disorder, and social anhedonia. Our group previously reported that childhood cat bites, but not ownership, related to increased schizotypy severity in an undergraduate sample. Methods: The current study expands this research by inquiring about cat bites and ownership in a transdiagnostic adult sample (N = 162; 51% female; mean age = 38.15, SD = 10.65), composed of schizophrenia spectrum disorders (n = 30), bipolar disorders (n = 30), unipolar depression (n = 23), and nonpsychiatric participants (n = 79). Participants completed a diagnostic interview, scales of symptom severity, and a cat interaction history interview. Results: Across the entire sample, self-report of cat bites prior to age 13, but not after, related to greater current severity of overall schizo-typy, self-reported and clinician-rated psychotic-like symptoms, and social anhedonia, when compared to individuals who reported no lifetime cat bites. Cat bites prior to age 13 did not relate to severity of depression, non-social anhedonia, or clinician-rated negative symptoms. Self-report of residing with a cat prior to age 13, or a first cat bite after age 12, did not relate to any symptom severity measure examined. Conclusions: One theory for these findings is that an unknown infectious agent common in cat saliva interacted with brain development in childhood to increase the likelihood of these symptoms. A novel theory for the infectious agent Pasteurella multocida is discussed. Future research can examine candidate infectious agents to identify potential causal mechanisms for these relationships.

show abstract

Bartonella henselae Bloodstream Infection in a Boy With Pediatric Acute-Onset Neuropsychiatric Syndrome

Cited by 38 publications

References 34 publications

Imaging analysis of Bartonella species in the skin using single‐photon and multi‐photon (second harmonic generation) laser scanning microscopy

Imaging analysis of Bartonella species in the skin using single‐photon and multi‐photon (second harmonic generation) laser scanning microscopy

Systematic search for schizophrenia pathways sensitive to perturbation by immune activation

Childhood Cat Bites Relate to Increased Adulthood Severity of Schizotypy, Psychotic-Like Experiences, and Social Anhedonia in a Transdiagnostic Psychiatric Sample

Contact Info

Product

Resources

About