<i>Bartonella</i>infection in urban and rural dogs from the tropics: Brazil, Colombia, Sri Lanka and Vietnam

Brenner, E.; Chomel, Bruno B; Singhasivanon, On-uma; Namekata, David Y.; Kasten, Rickie W.; Kass, Philip H.; Cortés-Vecino, Jesús A.; Gennari, Solange Maria; Rajapakse, R. P. V. J.; Huong, Lam Thi Thu; Dubey, J. P.

doi:10.1017/s0950268812000519

Cited by 33 publications

(28 citation statements)

References 39 publications

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“…Although cats are known to play a major role as B. henselae reservoirs in Chile [13], our results suggest that this species is also circulating in domestic dogs from the country. As observed before in Brazil [9] and Colombia [8], and described in Africa and Asia [1], rural and stray dogs, such as the dogs from Valdivia Province, are more likely to be infected or seroreactive to Bartonella spp. Bartonella vinsonii subsp.…”

Section: Epidemiology and Infection 1203supporting

confidence: 68%

Bartonella vinsonii subsp. berkhoffii andB.henselaein dogs

Müller

Soto

Sepúlveda³

et al. 2018

Epidemiol. Infect.

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This study aimed to molecularly survey Bartonella in dogs from Chile. Quantitative real-time PCR (qPCR) for Bartonella spp. based on nuoG gene was performed in 139 blood samples taken from dogs belonging to rural localities of the Valdivia Province, Los Ríos region, southern Chile. nuoG qPCR-positive samples were submitted to conventional PCR assays for ftsZ, gltA, rpoB and nuoG genes and sequencing for speciation and phylogenetic analysis. Based upon qPCR results, Bartonella spp. occurrence in dogs was 4.3% (6/139). Out of six nuoG qPCR-positive samples, six, three, two and none showed positive results in cPCR assays based on gltA, ftsZ, rpoB and nuoG genes, respectively. Consistent sequencing results were obtained only for the ftsZ gene from sample #1532 (GeneBank accession number: MG252491), and gltA gene from samples #1535 (MG252490) and #1532 (148 bp fragment that was not deposited in GenBank). Phylogenetic analysis of ftsZ and gltA genes allowed speciation of two nuoG-positive samples, one as Bartonella vinsonii subsp. berkhoffii and the other as B. henselae. Bartonella vinsonii subsp. berkhoffii and B. henselae are detected for the first time in dogs from Chile, highlighting the importance of the canine population as a source of zoonotic agents and potential infection risk to humans.

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Section: Epidemiology and Infection 1203supporting

confidence: 68%

Bartonella vinsonii subsp. berkhoffii andB.henselaein dogs

Müller

Soto

Sepúlveda³

et al. 2018

Epidemiol. Infect.

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“…Dogs experimentally infected with single species of Bartonella did not develop cross‐reactive antibodies against other species, but the extent to which serologic cross‐reactivity versus co‐exposure to multiple Bartonella species occurs in naturally infected dogs is unknown. Previous studies have shown poor associations between seroreactivity and bacteremia, with antibody reactivity to Bartonella species antigens detected in ≤50% of dogs and humans in which active infection with B. vinsonii subsp. berkhoffii and B. henselae can be documented .…”

Section: Discussionmentioning

confidence: 94%

BartonellaSeroepidemiology in Dogs from North America, 2008–2014

Lashnits

Correa

Hegarty

et al. 2017

Veterinary Internal Medicne

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BackgroundImproved understanding of Bartonella species seroepidemiology in dogs may aid clinical decision making and enhance current understanding of naturally occurring arthropod vector transmission of this pathogen.ObjectivesTo identify demographic groups in which Bartonella exposure may be more likely, describe spatiotemporal variations in Bartonella seroreactivity, and examine co‐exposures to other canine vector‐borne diseases (CVBD).AnimalsA total of 15,451 serology specimens from dogs in North America were submitted to the North Carolina State University, College of Veterinary Medicine Vector Borne Disease Diagnostic Laboratory between January 1, 2008, and December 31, 2014.Methods Bartonella henselae, Bartonella koehlerae, and Bartonella vinsonii subspecies berkhoffii indirect fluorescent antibody (IFA) serology results, as well as results from a commercial assay kit screening for Dirofilaria immitis antigen and Ehrlichia species, Anaplasma phagocytophilum, and Borrelia burgdorferi antibodies, and Ehrlichia canis, Babesia canis, Babesia gibsoni, and Rickettsia species IFA results were reviewed retrospectively.ResultsOverall, 3.26% of dogs were Bartonella spp. seroreactive; B. henselae (2.13%) and B. koehlerae (2.39%) were detected more frequently than B. vinsonii subsp. berkhoffii (1.42%, P < 0.0001). Intact males had higher seroreactivity (5.04%) than neutered males (2.87%, P < 0.0001) or intact or spayed females (3.22%, P = 0.0003). Mixed breed dogs had higher seroreactivity (4.45%) than purebred dogs (3.02%, P = 0.0002). There was no trend in seasonal seroreactivity; geographic patterns supported broad distribution of exposure, and co‐exposure with other CVBD was common.Conclusions and Clinical Importance Bartonella spp. exposure was documented throughout North America and at any time of year. Male intact dogs, mixed breed dogs, and dogs exposed to other CVBD have higher seroreactivity to multiple Bartonella species.

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“…henselae, when combined with B. quintana, accounts for over 90% of Bartonella endocarditis cases (107). Bartonella species in general have wide geographic distribution, possibly due to the geographic specificity of their respective hosts and vectors (156)(157)(158)(159)(160)(161)(162). For example, DNA of several species of Bartonella was isolated from bat flies and bats in Africa, Asia, Europe, and both North and South America (163).…”

Section: Epidemiology Of Bartonella Endocarditismentioning

confidence: 99%

Bartonella Species, an Emerging Cause of Blood-Culture-Negative Endocarditis

et al. 2017

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Since the reclassification of the genus in 1993, the number of species has grown from 1 to 45 currently designated members. Likewise, the association of different species with human disease continues to grow, as does the range of clinical presentations associated with these bacteria. Among these, blood-culture-negative endocarditis stands out as a common, often undiagnosed, clinical presentation of infection with several different species. The limitations of laboratory tests resulting in this underdiagnosis of endocarditis are discussed. The varied clinical picture of infection and a review of clinical aspects of endocarditis caused by are presented. We also summarize the current knowledge of the molecular basis of pathogenesis, focusing on surface adhesins in the two species that most commonly cause endocarditis, and. We discuss evidence that surface adhesins are important factors for autoaggregation and biofilm formation by species. Finally, we propose that biofilm formation is a critical step in the formation of vegetative masses during-mediated endocarditis and represents a potential reservoir for persistence by these bacteria.

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Bartonellainfection in urban and rural dogs from the tropics: Brazil, Colombia, Sri Lanka and Vietnam

Cited by 33 publications

References 39 publications

Bartonella vinsonii subsp. berkhoffii andB.henselaein dogs

Bartonella vinsonii subsp. berkhoffii andB.henselaein dogs

BartonellaSeroepidemiology in Dogs from North America, 2008–2014

Bartonella Species, an Emerging Cause of Blood-Culture-Negative Endocarditis

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