bb0689
contributes to the virulence of
Borrelia burgdorferi
in a murine model of Lyme disease
Connor Waldron,
Sierra George,
Christina Thompson
et al.
Abstract:Borrelia burgdorferi
, the Lyme disease pathogen, continuously changes its gene expression profile in order to adapt to ticks and mammalian hosts. The alternative sigma factor RpoS plays a central role in borrelial host adaptation. Global transcriptome analyses suggested that more than 100 genes might be regulated by RpoS, but the main part of the regulon remains unexplored. Here, we showed that the expression of
bb0689
, a gene encoding an outer surface lipoprotein wi… Show more
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