<i>Bifidobacterium animalis</i> subsp. <i>lactis</i> XLTG11 improves antibiotic-related diarrhea by alleviating inflammation, enhancing intestinal barrier function and regulating intestinal flora

Xu, Biao; Liang, Shengnan; Zhao, Jian; Li, Xuetong; Guo, Jiayao; Xin, Bowen; Li, Bailiang; Gui-cheng, Huo; Ma, Weiwei

doi:10.1039/d1fo04305f

Cited by 36 publications

(19 citation statements)

References 61 publications

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“…For example, VSL#3 (Cheng et al, 2020), which was considered as medical food, contains eight live strains of bacteria, including four strains of Lactobacillus, three strains of Bifidobacterium and one strain of Streptococcus. B. lactis XLTG11 was isolated from the intestine of healthy infants with excellent probiotic properties, which can regulate the immunity system, alleviate inflammation, enhance intestinal barrier and regulate gut microbiota (Weiwei et al, 2022;Xu et al, 2022). It has been suggested that Lactobacillus plantarum P8 can survive in the host intestine, improve the community structure of intestinal flora, reduce the adhesion, infestation and colonization of harmful bacteria, promote the growth of beneficial bacteria, enhance the barrier function of intestinal flora, and have a positive regulatory effect on humoral immunity, cellular immunity and immunity of intestine-related lymphoid tissues (Wang et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…It was shown that the B. lactis XLTG11, L. casei Zhang and L. plantarum P8 could enhance immune function in mice, respectively (Wang et al, 2013(Wang et al, , 2014Fu et al, 2020;Weiwei et al, 2022;Xu et al, 2022). However, studies on enhancing effects of complex probiotic preparations containing B. lactis XLTG11, L. casei Zhang and L. plantarum P8 have not been reported.…”

Section: Introductionmentioning

confidence: 99%

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Immunomodulatory effects of complex probiotics on the immuno-suppressed mice induced by cyclophosphamide

Li²,

Yu³

et al. 2023

Front. Microbiol.

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IntroductionPrevious studies have reported the beneficial effects of Bifidobacterium animalis subsp. lactis XLTG11, Lacticaseibacillus casei Zhang, and Lactiplantibacillus plantarum P8, respectively. However, studies on the immunomodulatory enhancing effects of three complex probiotics have not been conducted. The aim of our study is to investigate the immunomodulatory effects of complex probiotics effect on the immunosuppressed mice induced by cyclophosphamide (CTX).MethodsAn immunocompromised mouse model was established by intraperitoneal injection of cyclophosphamide, which was gavage of different doses of complex probiotics and levamisole hydrochloride. The splenic and thymic indices, intestinal barrier, leukocyte and lymphocyte counts, percentage of splenic lymphocyte subpopulations, cytokine levels, and gut microbiota were determined.ResultsResults showed that the complex probiotics significantly elevated the spleen and thymus indices, increased the villi and crypt depth and the goblet cells. The leukocyte and lymphocyte counts and the percentage of splenic lymphocyte subpopulations in the CTX-treated mice were significantly elevated by the complex probiotics. In addition, the cytokines (IL-6, IL-10, IL-1β, and IFN-γ) were significantly increased after complex probiotic treatment. The complex probiotics restored the gut microbiota structure to the pattern of the control group by reducing the ratio of Firmicutes/Bacteroidetes and enhancing the relative abundances of specific microbiota that produced short-chain fatty acids.DiscussionThis study provides theoretical support for the immunity-enhancing function of the complex probiotics as well as a pharmacological basis for its further development and utilization.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immunomodulatory effects of complex probiotics on the immuno-suppressed mice induced by cyclophosphamide

Li²,

Yu³

et al. 2023

Front. Microbiol.

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“…AAD is often accompanied by systemic inflammation, characterized by a significant increase in proinflammatory factors and a significant decrease in anti-inflammatory factors [ 53 ]. Changes in proinflammatory cytokines include tumor necrosis factor and interleukins, both of which play a primary role in communicating with immune cells and reflect inflammatory infiltration in the host [ 54 ]. Therefore, the levels of inflammatory cytokines are evaluated in AAD, including TNF and IL-8.…”

Section: Discussionmentioning

confidence: 99%

Effect of Traditional Chinese Medicine on Treating Antibiotic-Associated Diarrhea in Children: A Systematic Review and Meta-Analysis

Sun

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Due to the limited treatment options in antibiotic-associated diarrhea (AAD) in children, more effective treatments should be explored. Traditional Chinese medicine (TCM) has a long history in China, which has produced a pretty effect in clinical practice. Many randomized clinical trials (RCTs) have explored the effect of traditional Chinese medicine on treating AAD in children. However, there has been no systematic review or meta-analysis on the impact of TCM on AAD in children. The aim of this study was to systematically review RCTs on the effect of TCM in children with AAD. Methods. RCTs in the past ten years on TCM for AAD in children were included. We searched Electronic databases as much as possible. This paper was registered in PROSPERO (CRD42022301034). Results. 26 studies were included in this systematic review. 25 studies reported the effects of TCM interventions on the total effective rate (RR = 1.20, CI 1.16 to 1.24; p < 0.001 ). 7 studies reported the effects of TCM interventions on the time to change the shape of feces (MD = −1.37, CI −1.67 to −1.07; p < 0.001 ). 17 studies reported the effects of TCM interventions (MD = −1.43, CI −1.71 to −1.15; p < 0.001 ). The pooled results showed that there were no significant differences between the two groups in CD3+, CD4+, CD8+, CD4 : CD8, time for bowel sounds to return to normal, hs-CRP, and IgM. There was a significant difference between the two groups in frequency of diarrhea on the third day after TCM intervention, vomiting improvement time, diamine oxidase, IL-8, TNF, IgA, IgG, and average hospital stay. Conclusions. TCM interventions combined with conventional therapy can improve the therapeutic effect of AAD in children. However, future studies are still needed for the low methodological quality.

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“…known to be effective in improving diarrhea and IBS-D. For example, L. plantarum 299v is known to be effective in controlling abdominal bloating [ 18 ], and Bifidobacterium animalis spp. XLTG11 is known to be effective in controlling antibiotic-related diarrhea [ 19 ]. Unfortunately, there has been no direct comparative study of whether combinations of probiotics are more effective than a single strain, and conclusions vary from disease to disease and from strain to strain.…”

Section: Discussionmentioning

confidence: 99%

A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Effects of Multi-Strain Synbiotic in Patients with Functional Diarrhea and High Fecal Calprotectin Levels: A Pilot Study

et al. 2022

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Synbiotics, including probiotics and prebiotics, are useful for patients with functional bowel disorders. However, which synbiotics are beneficial for patients with which diseases, especially those with functional diarrhea (FDr) with high fecal calprotectin levels, is currently unknown. FDr is an extension of irritable bowel syndrome with diarrhea (IBS-D). Although fewer studies have been conducted on FDr compared to IBS-D, its importance is increasing as its prevalence increases. The aim of this study was to evaluate the effects of a synbiotic containing a mixture of Lactobacillus and Bifidobacterium and its substrate, fructooligosaccharide, on bowel symptoms, fecal calprotectin levels, fecal microbiota, and safety in FDr patients with high fecal calprotectin levels. Forty patients were randomly assigned to either a synbiotic group or a placebo group. A total of 20 subjects in the synbiotic group and 19 subjects in the placebo group completed the study (8 weeks). Changes in FDr symptoms, fecal calprotectin levels, and gut microbiota were assessed during the intervention period. At 4 and 8 weeks, the number of bowel movements tended to increase in the synbiotic group, with a significant increase in the number of formed stools rather than loose stools (p < 0.05). Bowel movement satisfaction was significantly increased in the synbiotic group, but not in the placebo group. Intestinal flora analysis revealed that Lactobacillales at the order level was increased only in the synbiotic group at the end of the intervention. In contrast, at week 8 of the intervention, log-transformed fecal calprotectin levels were significantly decreased in the synbiotic group, although the change was not significantly different from that of the placebo group. These findings suggest that the intake of a multi-strain-containing synbiotic for 8 weeks could improve gut symptoms and the intestinal microenvironment of FDr patients with high fecal calprotectin levels.

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Bifidobacterium animalis subsp. lactis XLTG11 improves antibiotic-related diarrhea by alleviating inflammation, enhancing intestinal barrier function and regulating intestinal flora

Abstract: Antibiotic-associated diarrhea (AAD) is a common side effect during antibiotic treatment.

Cited by 36 publications

References 61 publications

Immunomodulatory effects of complex probiotics on the immuno-suppressed mice induced by cyclophosphamide

Immunomodulatory effects of complex probiotics on the immuno-suppressed mice induced by cyclophosphamide

Effect of Traditional Chinese Medicine on Treating Antibiotic-Associated Diarrhea in Children: A Systematic Review and Meta-Analysis

A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Effects of Multi-Strain Synbiotic in Patients with Functional Diarrhea and High Fecal Calprotectin Levels: A Pilot Study

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