<i>Bmp4</i>
            and Morphological Variation of Beaks in Darwin's Finches

Abzhanov, Arhat; Protas, Meredith E.; Grant, B. Rosemary; Grant, Peter R.; Tabin, Clifford J.

doi:10.1126/science.1098095

Cited by 702 publications

(635 citation statements)

References 13 publications

Supporting

Mentioning

612

Contrasting

Unclassified

Order By: Relevance

“…Increased expression of BMP2, BMP4, and BMP7 in the FEZ (Fig. 2R, this study; Hu et al, 2003;Abzhanov et al, 2004;Marcucio et al, 2005;Foppiano et al, 2007) and fading of FGF8 expression from the midfacial ectoderm result in downregulation of TBX22 in the medial part of the face. This mode of TBX22 regulation is supported by the results of NOGGIN bead implantations into the lateral nasal or frontonasal processes, which resulted in preservation of TBX22 expression around the nasal pits and in the midfacial area close to the inductive FGF8 signal.…”

Section: Fgf and Bmp Signaling Pathways Converge On The Regulation Ofmentioning

confidence: 52%

Regulation of Tbx22 during facial and palatal development

Fuchs

Inthal

Herrmann

et al. 2010

Developmental Dynamics

View full text Add to dashboard Cite

Mutations in the gene encoding the T-box transcription factor TBX22 cause X-linked cleft palate and ankyloglossia in humans. Here we show that Tbx22 expression during facial and palatal development is regulated by FGF and BMP signaling. Our results demonstrate that FGF8 induces Tbx22 in the early face while BMP4 represses and thus restricts its expression. This regulation is conserved between chicken and mouse, although the Tbx22-expression patterns differ considerably between these two species. We suggest that these species-specific differences may result at least in part from differences in the spatiotemporal patterns of BMP activity, but we exclude a direct repression of Tbx22 by the BMP-inducible transcriptional repressor MSX1. Together these findings help to integrate Tbx22 into the molecular network of factors regulating facial development. Developmental Dynamics 239:2860-2874,

show abstract

Section: Fgf and Bmp Signaling Pathways Converge On The Regulation Ofmentioning

confidence: 52%

Regulation of Tbx22 during facial and palatal development

Fuchs

Inthal

Herrmann

et al. 2010

Developmental Dynamics

View full text Add to dashboard Cite

show abstract

“…The potent influence of BMPs upon many aspects of neural crest development and the wide variety of neural crest phenotypes we observed as alleles of BMP antagonists were deleted in the various single and double mutants suggest that NCC development is very sensitive to modulations in BMP signaling. Variations in BMP levels have been shown to regulate beak morphology in chick embryos by means of modulating outgrowth of the frontonasal mass (Wu et al, 2004;Abzhanov et al, 2004), which involves extensive colonization by NCCs. Moreover, levels of BMP4 expression in the embryonic frontonasal mass correlate with variations in beak morphology among species of Darwin's finches (Abzhanov et al, 2004).…”

Section: Bmp Antagonism and Craniofacial Diversitymentioning

confidence: 99%

“…Variations in BMP levels have been shown to regulate beak morphology in chick embryos by means of modulating outgrowth of the frontonasal mass (Wu et al, 2004;Abzhanov et al, 2004), which involves extensive colonization by NCCs. Moreover, levels of BMP4 expression in the embryonic frontonasal mass correlate with variations in beak morphology among species of Darwin's finches (Abzhanov et al, 2004). Similarly, species variations in the rostral expression of BMP antagonists could facilitate morphological change in craniofacial structures, for example by altering levels of apoptosis during NCC colonization and proliferation of the facial prominences.…”

Section: Bmp Antagonism and Craniofacial Diversitymentioning

confidence: 99%

Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival

Anderson

Stottmann

Choi

et al. 2006

Developmental Dynamics

View full text Add to dashboard Cite

We demonstrate here that Chordin and Noggin function as bone morphogenetic protein (BMP) antagonists in vivo to promote mammalian neural crest development. Using Chrd and Nog single and compound mutants, we find that Noggin has a major role in promoting neural crest formation, in which Chordin is partially redundant. BMP signaling is increased in dorsal tissues lacking Noggin and is further increased when Chordin is also absent. The early neural crest domain is expanded with decreased BMP antagonism in vivo. Noggin and Chordin also regulate subsequent neural crest cell emigration from the neural tube. However, reduced levels of these BMP antagonists ultimately result in perturbation of neural crest cell derived peripheral nervous system and craniofacial skeletal elements. Such defects reflect, at least in part, a function to limit apoptosis in neural crest cells. Noggin and Chordin, therefore, function together to regulate both the generation and survival of neural crest cells in mammalian development. Developmental Dynamics 235:2507-2520, 2006.

show abstract

“…Ideal systems to study the role of chance and necessity in ecological evolution would be related species or populations with readily observable phenotypic variation, living in a tractable ecological setting, and most crucially showing parallel evolution of specific traits within/among species/populations. Examples of such a species complex are the finches of the Galapagos islands, cichlids in the African great lakes are exciting multi-species systems in this respect 6, 7 . The threespine stickleback has also emerged as a model “single species” system 8 .…”

Section: Introductionmentioning

confidence: 99%

The developmental transcriptome of contrasting Arctic charr (Salvelinus alpinus) morphs

et al. 2015

View full text Add to dashboard Cite

Species and populations with parallel evolution of specific traits can help illuminate how predictable adaptations and divergence are at the molecular and developmental level. Following the last glacial period, dwarfism and specialized bottom feeding morphology evolved rapidly in several landlocked Arctic charr Salvelinus alpinus populations in Iceland. To study the genetic divergence between small benthic morphs and limnetic morphs, we conducted RNA-sequencing charr embryos at four stages in early development. We studied two stocks with contrasting morphologies: the small benthic (SB) charr from Lake Thingvallavatn and Holar aquaculture (AC) charr.The data reveal significant differences in expression of several biological pathways during charr development. There was also an expression difference between SB- and AC-charr in genes involved in energy metabolism and blood coagulation genes. We confirmed differing expression of five genes in whole embryos with qPCR, including lysozyme and natterin-like which was previously identified as a fish-toxin of a lectin family that may be a putative immunopeptide. We also verified differential expression of 7 genes in the developing head that associated consistently with benthic v.s.limnetic morphology (studied in 4 morphs). Comparison of single nucleotide polymorphism (SNP) frequencies reveals extensive genetic differentiation between the SB and AC-charr (~1300 with more than 50% frequency difference). Curiously, three derived alleles in the otherwise conserved 12s and 16s mitochondrial ribosomal RNA genes are found in benthic charr.The data implicate multiple genes and molecular pathways in divergence of small benthic charr and/or the response of aquaculture charr to domestication. Functional, genetic and population genetic studies on more freshwater and anadromous populations are needed to confirm the specific loci and mutations relating to specific ecological traits in Arctic charr.

show abstract

Bmp4 and Morphological Variation of Beaks in Darwin's Finches

Cited by 702 publications

References 13 publications

Regulation of Tbx22 during facial and palatal development

Regulation of Tbx22 during facial and palatal development

Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival

The developmental transcriptome of contrasting Arctic charr (Salvelinus alpinus) morphs

Contact Info

Product

Resources

About