<i>Boletus aereus</i> protects against acute alcohol-induced liver damage in the C57BL/6 mouse via regulating the oxidative stress-mediated NF-κB pathway

Zhang, Luping; Meng, Bo; Li, Lanzhou; Wang, Yanzhen; Zhang, Yuan‐Zhu; Fang, Xuexun; Wang, Di

doi:10.1080/13880209.2020.1812672

Cited by 12 publications

(5 citation statements)

References 57 publications

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“…The nutritional composition, including the levels of total sugar, reducing sugar, crude protein, total ash, crude fat, crude fiber, total flavonoids, total triterpenoids, mannitol, total phenol, total sterol, and vitamins in ADe was systematically measured as described in our previous study [ 28 ]. Total saponins and total alkaloids were assessed via UV spectrophotometry [ 29 , 30 ].…”

Section: Methodsmentioning

confidence: 99%

Anti-Obesity Effect of Auricularia delicate Involves Intestinal-Microbiota-Mediated Oxidative Stress Regulation in High-Fat-Diet-Fed Mice

Zhai

Wang

et al. 2023

Nutrients

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Auricularia delicate (ADe), an edible fungus belonging to the family Auriculariaceae and order Auriculariales, possesses antimicrobial, hepatoprotective, and antioxidant effects. In this study, after systematic analysis of its composition, ADe was administered to high-fat-diet (HFD)-fed mice to investigate its anti-obesity effect. ADe significantly controlled body weight; alleviated hepatic steatosis and adipocyte hypertrophy; reduced aspartate aminotransferase, total cholesterol, insulin, and resistin; and increased adiponectin levels in HFD-fed mice serum. Based on intestinal microbiota and lipidomics analysis, ADe treatment regulated the composition and abundance of 49 intestinal microorganisms and influenced the abundance of 8 lipid species compared with HFD-fed mice. Based on a correlation analysis of the intestinal microbiota and lipids, Coprococcus showed significant negative associations with ceramide (d18:0 20:0+O), phosphatidylserine (39:4), sphingomyelin (d38:4), and zymosterol (20:2). Moreover, ADe treatment decreased the levels of ROS and MDA and increased the levels of Nrf2, HO-1, and three antioxidant enzymes in HFD-fed mice livers. Collectively, the anti-obesity effect of ADe involves the regulation of oxidative stress and is mediated by the intestinal microbiota. Hence, this study provides a reference for the application of ADe as a candidate food for obesity.

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Section: Methodsmentioning

confidence: 99%

Anti-Obesity Effect of Auricularia delicate Involves Intestinal-Microbiota-Mediated Oxidative Stress Regulation in High-Fat-Diet-Fed Mice

Zhai

Wang

et al. 2023

Nutrients

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“…Non-starch polysaccharides are important components of dietary fiber, and many non-starch polysaccharides are not easy to be decomposed by human digestive enzymes [26] . Some non-starch polysaccharides can be digested and degraded into reducing sugars by human enzymes [27] .…”

Section: Reduced Sugar Release During In Vitro Digestionmentioning

confidence: 99%

Adsorption, in vitro digestion and human gut microbiota regulation characteristics of three Poria cocos polysaccharides

Zhang,

Zheng,

Zheng

et al. 2024

Food Science and Human Wellness

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Poria cocos (PC) is a famous traditional Chinese medicine (TCM) and a widely used healthcare ingredient, which has antiobesity, enhancing immunity and improving sleep effects. Traditionally, only water-soluble poria polysaccharide (WSP) is extracted and applied for clinical application, while insoluble polysaccharide (alkali-soluble poria polysaccharide, ASP) is discarded as herb residue. However, the whole PC has also been historically utilized as functional herbal food. Considering the benefi cial role of dietary fi ber and the traditional use of PC, ASP may also contribute substantially to the therapy function of PC. Compared to WSP, little attention has been paid to ASP and ASP modifi ed product carboxymethyl poria polysaccharide (CMP) which has been used as an antitumor adjuvant drug. In this study, the oil, cholesterol, metal ions and polyphenols adsorption ability, in vitro simulated digestive and the gut microbiota fermentation characteristics of WSP, ASP and CMP were studied to evaluate the functional values of three P. cocos polysaccharides (PCPs). The results showed that all three PCPs had good adsorption capacity on cholesterol, polyphenols and metal ions (Cd 2+ /Zn 2+ /Mg 2+ ), among which ASP showed the highest capacity than WSP and CMP. The adsorption capacity of all three PCPs on heavy metal ions (Cd 2+ /Zn 2+ ) was stronger than that of non-heavy metal ions (Mg 2+ ); The in vitro digestibility of all three PCPs was very low, but WSP was slightly higher than ASP and CMP; Moreover, the indigestible residue of all three PCPs could improve the richness and diversity of gut microbiota, among which ASP had the greatest infl uence. In general, ASP and CMP could signifi cantly promote the proliferation of some probiotics and inhibit the growth of some harmful bacteria. The gut microbiota diversity of CMP was reduced, but the richness of probiotics, especially Parabacteroides distasonis was significantly enhanced compared with the ASP group, and the growth of harmful bacteria Klebsiella pneumoniae was inhibited after CMP treatment. The short-chain fatty acids (SCFAs) analysis results showed that all three PCPs could signifi cantly promote the production of acetic acid, propionic acid and the total acid content compared with blank control group, and SCFAs producing activity was positively correlated with the proliferative capacity of probiotics. Taken together, the good adsorption characteristics and gut microbiota regulatory activity of ASP may lay foundation for its lipid-lowering and immune-improving function. Additionally, the probiotic effect of CMP and ASP indicated that except for only use the water extract of PC in clinic, CMP and ASP also can be used in healthcare to take full advantage of this valuable medicine.

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“…To date, there were only a few clinical reports on the poisoning activities of Boletus mushrooms [ 27 , 28 ]. While many natural compounds isolated from Boletus mushrooms were reported, such as those with apoptotic effect in cancer cells [ 29 ], antioxidant effect [ 30 ], and a liver-protective effect in mice [ 31 ]. Nevertheless, the immunomodulatory effect of RB is worth further investigating in the future.…”

Section: The Hong Kong Experience: Immunological Properties Of Medicinal Herbs Used Against Cancermentioning

confidence: 99%

Medicinal Plants and Mushrooms with Immunomodulatory and Anticancer Properties—A Review on Hong Kong’s Experience

2021

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The immune modulating effects of selected herbs deserve careful studies to gain evidence-based support for their further development. We have been working hard on many items of medicinal herbs to gain insight into their immunomodulatory effects relevant to cancer treatment in particular, while infection control is not excluded. Nine of them have been selected to give the results of our exploration on their biological, particularly immunomodulatory activities. Since Hong Kong people especially favor one medicinal mushroom, viz. Coriolus versicolor, a number of clinical trials using Coriolus for cancer-related studies are included in this review. While immune modulation platforms are being built for relevant studies, a brief account on the research targets and related procedures are given.

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Boletus aereus protects against acute alcohol-induced liver damage in the C57BL/6 mouse via regulating the oxidative stress-mediated NF-κB pathway

Abstract: (2020) Boletusaereus protects against acute alcohol-induced liver damage in the C57BL/6 mouse via regulating the oxidative stress-mediated NF-κB pathway,

Cited by 12 publications

References 57 publications

Anti-Obesity Effect of Auricularia delicate Involves Intestinal-Microbiota-Mediated Oxidative Stress Regulation in High-Fat-Diet-Fed Mice

Anti-Obesity Effect of Auricularia delicate Involves Intestinal-Microbiota-Mediated Oxidative Stress Regulation in High-Fat-Diet-Fed Mice

Adsorption, in vitro digestion and human gut microbiota regulation characteristics of three Poria cocos polysaccharides

Medicinal Plants and Mushrooms with Immunomodulatory and Anticancer Properties—A Review on Hong Kong’s Experience

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