<i>Bordetella parapertussis</i> Bacteremia: Clinical Expression and Bacterial Genomics

Toubiana, Julie; Azarnoush, Saba; Bouchez, Valérie; Landier, Annie; Guillot, Sophie; Matczak, Soraya; Bonacorsi, Stéphane; Brisse, Sylvain

doi:10.1093/ofid/ofz122

Cited by 13 publications

(8 citation statements)

References 25 publications

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“…[5] Typical symptoms include a paroxysmal cough, post-tussive vomiting, and subconjunctival hemorrhage. B parapertussis can cause severe invasive infections, [3,12] mostly in immunocompromised hosts. [2] Patients with acute EB infection may be considered immunocompromised owing to their susceptibility to infection.…”

Section: Discussionmentioning

confidence: 99%

Case report: Plastic bronchitis associated with Bordetella parapertussis

Li¹,

Xu²,

Shen³

2023

Medicine

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Rationale: Bordetella parapertussis caused by a severe infection is rare in clinical practice. Here, we report a case of plastic bronchitis (PB). Patient concerns: A 4-year-old girl with a 2-day history of fever, paroxysmal cough, and subconjunctival hemorrhage. Diagnoses: The diagnoses were (1) B parapertussis, (2) pulmonary atelectasis, and (3) PB. Interventions: The patient received azithromycin and underwent bronchoscopy. Outcomes: Symptoms disappeared after treatment. The patient had an outpatient follow-up of 2 months without respiratory symptoms. Lessons: PB can lead to respiratory failure if not intervened in the early stages.

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Section: Discussionmentioning

confidence: 99%

Case report: Plastic bronchitis associated with Bordetella parapertussis

Li¹,

Xu²,

Shen³

2023

Medicine

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“…It plays an important role in B. pertussis as a virulence factor mediating adhesion of bacterium to the host cell and is also shown to be expressed in B. parapertussis [36]. The multilocus sequence typing (MLST) analysis according to 7-gene scheme [37] shows IRBP134 belonged to ST19 as it is reported for B. parapertussis strain 12822, FR6242 and some other recently collected isolates [24].…”

Section: Microevolutionary Analysismentioning

confidence: 97%

“…The genetic relationships of the Iranian B. parapertussis isolate, IRBP134, with global available isolates was compared (Figure -1) with 102 available human B. parapertussis genomes representing seven countries from 1974 to 2018 from multiple studies mainly collected from the United States (Supplementary File-3) [15,24]. The maximum parsimony tree was constructed using 896 SNPs against B. parapertussis strain 12822.…”

Section: Global Relationships Of B Parapertussis Isolatesmentioning

confidence: 99%

“…Pertactin is an important surface antigen in B. pertussis and B. parapertussis as an adhesion factor that is also included in ACVs. B. parapertussi isolates that do not express pertacin were reported in France in recent years [12,24]. Since 2007, the majority of collected B. parapertussis isolates 94.3% in France have not expressed Prn suggested to be due the ACV vaccine pressure [25].…”

Section: Prn Expressionmentioning

confidence: 99%

“…Since B. parapertussis cause pertussis with milder symptoms, they isolated and reported less than B. pertussis and there are very few studies investigating the adaptation of clinical B. parapertiussis isolates [3,6,12]. Genotyping of major virulence associated genes revealed IRBP134 had similar virulence associated genes of the reference genome and only exception is in the brkB gene that like other B. parapertussis isolates [24], it carries allele 6 of brkB gene, encoding Bordetella serum resistance (Supplementary File-2). This allele variation is a result of a nonsynonymous SNP changing polar Threonine to nonpolar Alanine in BrkB in position 742 of an immunologic protein of B. pertussis.…”

Section: Microevolutionary Analysismentioning

confidence: 99%

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Genome characteristic of Bordetella parapertussis isolated from Iran

Safarchi

Saedi

Tay

et al. 2022

Preprint

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Pertussis also known as whooping cough is a respiratory infection in humans particularly in infants and usually caused by Bordetella pertussis. However, Bordetella parapertussis can also cause a similar clinical syndrome. During 2012 to 2015, from nasal swabs sent from different provinces to the pertussis reference laboratory of Pasture Institute of Iran for pertussis confirmation, seven B. parapertussis isolates were identified by bacterial culture, biochemical tests, and the presence of IS1001 insertion in the genome by real-time PCR. Furthermore, the expression of pertactin (Prn) as one the major virulence factor for bacterial adhesion was investigated using western blot. Moreover, the genomic characteristic of one recently collected isolate, IRBP134, from a seven-month infant was investigated using Illumina NextSeq sequencing protocol. The results revealed the genome with G+C content 65% and genome size 4.7 Mbp. A total of 81 single nucleotide polymorphisms (SNPs) and 13 short insertion and deletions were found in the genome compared to the B. parapertussis 12822 as a reference genome showing ongoing evolutionary changes in our isolate. A phylogeny relationship of IRBP134 was also investigated using global B. parapertussis available genomes.

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Genome Characteristic of Bordetella parapertussis Isolated from Iran

et al. 2022

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Pertussis also known as whooping cough is a respiratory infection in humans particularly with severe symptoms in infants and usually caused by Bordetella pertussis. However, Bordetella parapertussis can also cause a similar clinical syndrome. During 2012 to 2015, from nasal swabs sent from different provinces to the pertussis reference laboratory of Pasture Institute of Iran for pertussis confirmation, seven B. parapertussis isolates were identified by bacterial culture, biochemical tests, and the presence of IS1001 insertion in the genome. The expression of pertactin (Prn) as one the major virulence factor for bacterial adhesion was investigated using western blot. Moreover, the genomic characteristic of one recently collected isolate, IRBP134, from a seven-month infant was investigated using Illumina NextSeq sequencing protocol. The results revealed the genome with G+C content 65% and genome size 4.7 Mbp. A total of 81 single nucleotide polymorphisms and 13 short insertions and deletions were found in the genome compared to the B. parapertussis 12822 as a reference genome showing ongoing evolutionary changes. A phylogeny relationship of IRBP134 was also investigated using global B. parapertussis available genomes.

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Bordetella parapertussis Bacteremia: Clinical Expression and Bacterial Genomics

Cited by 13 publications

References 25 publications

Case report: Plastic bronchitis associated with Bordetella parapertussis

Case report: Plastic bronchitis associated with Bordetella parapertussis

Genome characteristic of Bordetella parapertussis isolated from Iran

Genome Characteristic of Bordetella parapertussis Isolated from Iran

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