<i>Bordetella pertussis</i>in Adult Pneumonia Patients1

Beynon, Kirsten A.; Young, Sheryl A.; Laing, Richard; Harrison, Timothy G.; Anderson, Trevor P.; Murdoch, David R.

doi:10.3201/eid1104.040822

Cited by 9 publications

(4 citation statements)

References 6 publications

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“…Infections with B . pertussis in humans are primarily associated with colonization of the upper respiratory tract and are more rarely associated with pneumonia [ 37 – 39 ]. To determine if infectious dose and routes had an impact on the distribution of the number of viable bacteria in the upper, middle, and lower respiratory tract of mice, we compared the proportion of viable bacteria from each tissue over time ( Fig 4A ).…”

Section: Resultsmentioning

confidence: 99%

“…Animals challenged with a high dose via aerosol maintained a relatively constant bacterial burden in Distribution of bacterial burden following infection correlates with bacterial dose rather than the method of administration. Infections with B. pertussis in humans are primarily associated with colonization of the upper respiratory tract and are more rarely associated with pneumonia [37][38][39]. To determine if infectious dose and routes had an impact on the distribution of the number of viable bacteria in the upper, middle, and lower respiratory tract of mice, we compared the proportion of viable bacteria from each tissue over time (Fig 4A).…”

Section: Intranasal and Aerosol Administration Of B Pertussis Leads T...mentioning

confidence: 99%

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Intranasal challenge with B. pertussis leads to more severe disease manifestations in mice than aerosol challenge

Weaver,

Bitzer,

Wolf

et al. 2023

PLoS ONE

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The murine Bordetella pertussis challenge model has been utilized in preclinical research for decades. Currently, inconsistent methodologies are employed by researchers across the globe, making it difficult to compare findings. The objective of this work was to utilize the CD-1 mouse model with two routes of challenge, intranasal and aerosol administration of B. pertussis, to understand the differences in disease manifestation elicited via each route. We observed that both routes of B. pertussis challenge result in dose-dependent colonization of the respiratory tract, but overall, intranasal challenge led to higher bacterial burden in the nasal lavage, trachea, and lung. Furthermore, high dose intranasal challenge results in induction of leukocytosis and pro-inflammatory cytokine responses compared to aerosol challenge. These data highlight crucial differences in B. pertussis challenge routes that should be considered during experimental design.

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Section: Resultsmentioning

confidence: 99%

Section: Intranasal and Aerosol Administration Of B Pertussis Leads T...mentioning

confidence: 99%

Intranasal challenge with B. pertussis leads to more severe disease manifestations in mice than aerosol challenge

Weaver,

Bitzer,

Wolf

et al. 2023

PLoS ONE

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“…However, to the best of our knowledge, there has not been a consensus as to whether individuals with GERD have an increased risk for pertussis diagnosis. Data analysis of community-acquired pneumonia cases in New Zealand showed B. pertussis was identified along with other respiratory pathogens such as Streptococcus pneumoniae , Haemophilus influenzae , respiratory syncytial virus, and influenza A virus [ 23 ]. Therefore, GERD as a risk factor for pertussis diagnosis may be in part attributable to GERD patients being susceptible to respiratory complications, and therefore being more likely to have B. pertussis detected.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Pertussis Among Older Adults in South Korea: A Nationwide Health Data-Based Case–Control Study

Kim

Shin

Chen³

et al. 2023

Infect Dis Ther

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Introduction: To better understand the conditions associated with pertussis diagnosis among older adults in South Korea, a matched case-control study was conducted of individuals C 50 years diagnosed with pertussis between 2009 and 2018. Methods: Pertussis cases were identified using the nationwide Health Insurance Review and Assessment service (HIRA) database. Each case was then matched to up to 10 controls identified using the National Health Insurance Service-National Sample Cohort (NHIS-NSC) by age, sex, and geographic region at index date. In the 12 months and 30 days prior to index date,

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“…NATs are now established tests for the detection of the causative agents of pertussis [50][51][52]. While Bordetella pertussis is the major cause of pertussis in humans and can be complicated by pneumonia [53,54], Bordetella bronchiseptica, Bordetella holmesii, and Bordetella parapertussis have all been occasionally associated with (often milder) pertussis-like illnesses [50]. NATs are the most sensitive methods for the detection of B. pertussis and, with rapid turnaround times, have been invaluable tools in outbreak management [55,56].…”

Section: Bordetella Pertussismentioning

confidence: 99%

How recent advances in molecular tests could impact the diagnosis of pneumonia

Murdoch

2016

Expert Review of Molecular Diagnostics

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Molecular diagnostic tests have been the single major development in pneumonia diagnostics over recent years. Nucleic acid detection tests (NATs) have greatly improved the ability to detect respiratory viruses and bacterial pathogens that do not normally colonize the respiratory tract. In contrast, NATs do not yet have an established role for diagnosing pneumonia caused by bacteria that commonly colonize the nasopharynx due to difficulties discriminating between pathogens and coincidental carriage strains. New approaches are needed to distinguish infection from colonization, such as through use of quantitative methods and identification of discriminating cut-off levels. The recent realization that the lung microbiome exists has provided new insights into the pathogenesis of pneumonia involving the interaction between multiple microorganisms. New developments in molecular diagnostics must account for this new paradigm.

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Bordetella pertussisin Adult Pneumonia Patients1

Cited by 9 publications

References 6 publications

Intranasal challenge with B. pertussis leads to more severe disease manifestations in mice than aerosol challenge

Intranasal challenge with B. pertussis leads to more severe disease manifestations in mice than aerosol challenge

Risk Factors of Pertussis Among Older Adults in South Korea: A Nationwide Health Data-Based Case–Control Study

How recent advances in molecular tests could impact the diagnosis of pneumonia

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