<i>Borrelia miyamotoi</i> Infections in Humans and Ticks, Northeastern China

Jiang, Bao-Gui; Jia, Na; Jiang, Jia-Fu; Zheng, Yuan-Chun; Chu, Yan-Li; Jiang, Rui-Ruo; Wang, Yawei; Liu, Hongbo; Wei, Ran; Zhang, Wenhui; Li, Yan; Xu, Xiaowei; Ye, Jinling; Yao, Nan-Nan; Liu, Xiaojing; Huo, Qiu-Bo; Sun, Yi; Song, Jie; Liu, Wei; Cao, Wu‐Chun

doi:10.3201/eid2402.160378

Cited by 56 publications

(61 citation statements)

References 21 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To date, several Ixodes tick species are considered as a vector of B. miyamotoi . For instance, I. scapularis and I. pacificus are the vectors reported in the United States and Canada, I. ricinus in Europe, and I. persulcatus in Europe and Asia [ 16 , 23 , 55 , 56 , 57 ]. So far, the reservoir hosts, based on the geographical distribution, for B. miyamotoi are still not well understood, but rodents and birds have been considered as the reservoir hosts in some regions [ 58 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Detection of Borrelia burgdorferi Sensu Lato and Relapsing Fever Borrelia in Feeding Ixodes Ticks and Rodents in Sarawak, Malaysia: New Geographical Records of Borrelia yangtzensis and Borrelia miyamotoi

Lau

Qiu²,

Moustafa

et al. 2020

Pathogens

View full text Add to dashboard Cite

Members of the Borrelia burgdorferi sensu lato (Bbsl) complex are etiological agents of Lyme disease (LD), and Borrelia miyamotoi is one of the relapsing fever Borrelia (RFB). Despite the serological evidence of LD in Malaysia, there has been no report from Sarawak, Malaysian Borneo. Thus, this study aimed to detect and characterize Borrelia in rodents and Ixodes ticks from primary forests and an oil palm (OP) plantation in Sarawak. Borrelia yangtzensis (a member of the Bbsl complex) was detected in 43.8% (14/32) of Ixodes granulatus; most of the positive ticks were from the OP plantation (13/14). Out of 56 rodents, B. yangtzensis was detected in four Rattus spp. from the OP plantation and B. miyamotoi was detected in one rodent, Sundamys muelleri, from the primary forest. Further, the positive samples of B. yangtzensis were randomly selected for multilocus sequence analysis (MLSA). The MLSA results of successfully amplified tick samples revealed a clustering with the sequences isolated from Japan and China. This study is the first evidence of B. miyamotoi, a known human pathogen in Malaysia, and B. yangtzensis, which is circulating in ticks and rodents in Sarawak, Malaysian Borneo, and presenting a new geographical record of the Borrelia spp.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Among these three, B. miyamotoi is pathogenic to humans [ 18 ], and B. theileri is responsible for bovine borreliosis [ 19 ]. B. miyamotoi infection in humans was first reported in Russia in 2011, and, since then, cases have been documented in the United States, Europe, Japan, and northeastern China [ 18 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Detection of Borrelia burgdorferi Sensu Lato and Relapsing Fever Borrelia in Feeding Ixodes Ticks and Rodents in Sarawak, Malaysia: New Geographical Records of Borrelia yangtzensis and Borrelia miyamotoi

Lau

Qiu²,

Moustafa

et al. 2020

Pathogens

View full text Add to dashboard Cite

show abstract

“…When ticks bit into the nude skin, they can not only cause animal or human itch, anemia and emaciation, but also spread pathogens such as bacteria, viruses, nematodes and protozoa, which would seriously threaten human health, animal husbandry production and wildlife survival. Tick-borne diseases mostly occur in temperate, tropical and subtropical regions (2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Identification of Amblyomma Javanense and Detection of Tick-Borne Ehrlichia Spp. In Confiscated Malayan Pangolins

Zhai

Wu²,

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundDue to habitat destruction and illegal hunting and trade, the number of pangolins has been sharply reduced. To prevent their extinction, relevant departments are combined and active action have been taken. A total of 21 confiscated Malayan pangolins were rescued in 2019, but died continuously for unknown reasons. This study aimed to investigate the reasons for the death of these pangolin and rescue them.MethodsRecused Malayan pangolins were checked for clinical symptoms. Ticks on the surface of pangolins were collected and identified using morphological and molecular biological methods. Dead pangolins were autopsied for the gross lesion and tissues were collected for microscopic lesion using HE staining. Viral and protozoa pathogens’ detection were carried on ticks firstly and further confirmed in dead pangolin pathological tissues using PCR.ResultsWhen rescued, pangolins were in bad situation. More than 90% (19/21) of the rescued pangolins had ticks on their body surfaces. A total of 303 ticks were removed and identified as Amblyomma javanense (A. javanense) according to their morphology and the sequences of PCR product of 16S rRNA and internal transcribed spacer 2 (ITS2). Autopsy of the dead pangolins showed multiorgan damage, especially congestion and hemorrhage in lung, heart and kidney. Histopathological analysis revealed marked presence of inflammation in tissues. Pathogens’ nucleic acid detection showed ticks were only positive for Ehrlichia spp, with 56.7% positive rate of collected ticks (127/224), which was further confirmed in tissues from dead pangolins. Sick pangolins reduced clinical symptoms after medical treatment of intramuscular injection with doxycycline and kept alive before transfer.ConclusionsOur findings confirm that ehrlichiosis caused by Ehrlichia spp. from A. javanense might be one of the reasons for the confiscated pangolins’ death. More attention should be payed to tick-elimination work and the diagnoses and treatment of tick-borne diseases in the follow-up rescue operation.

show abstract

“…Subsequently, DNA of B. miyamotoi have been found in Ixodes ticks in Asia (China, Korea, Japan and Russia), North America (United States and Canada) and Europe (France, Czech Republic, Norway, Poland, Belgium, England, Denmark, Estonia, Sweden, Switzerland, Germany and Hungary, Netherlands and Spain) [1,2,3,4,5]. They had been considered to be non-pathogenic bacteria for humans until the first cases of infected people were diagnosed in Russia in 2009 [6].…”

Section: Introductionmentioning

confidence: 99%

“…Borrelia miyamotoi status as a pathogen was established only recently. Subsequently, cases have been 3 described in the USA, Europe and Japan and China but the incidence rate of the disease in humans is not known [1,7,8,9]. In Poland, B miyamotoi studies were carried out on ticks.…”

Section: Introductionmentioning

confidence: 99%

Borrelia miyamotoi DNA in a patient suspected of Lyme borreliosis

Fiecek

Lewandowska

Roguska

et al. 2019

Preprint

View full text Add to dashboard Cite

Background Clinical manifestations in infection caused by B. miyamotoi can mimick highly variable symptoms of Lyme disease. The aim of our studies was to detect DNA of B. miyamotoi spirochetes in clinical materials from patients suspected of neuroborreliosis(retrospectively).Methods Samples of blood serum and cerebrospinal fluid were collected from 133 patients with clinical manifestations of neuroborreliosis. Diagnosis was established by detection of IgM and / or IgG specific antibodies to B. burgdorferi with ELISA in both sera and CSF. Specificity of positive ELISA results in sera were confirmed with Western-blot test. Bacterial DNA from the collected material was extracted, amplified and sequenced.Results Among 133 patients with clinical manifestations of neuroborreliosis recognized in the years 2010-2018., DNA of B. miyamotoi was detected in CSF from 1 (0.8%) patient with extraocular optic neuritis of the left eye (GenBank accession No. MK674170 and MK674171).Conclusion Detection of B. miyamotoi in patients with central nervous system infections, will allow a better understanding of the epidemiology of infections caused by Borrelia sp. spirochetes. Patients with neurological symptoms and questionable serological findings are a serious diagnostic problem, due to failure to meet the criteria for neuroboreliosis. This indicates the need for further studies of patients with signs of CNS infection.

show abstract

Borrelia miyamotoi Infections in Humans and Ticks, Northeastern China

Cited by 56 publications

References 21 publications

Detection of Borrelia burgdorferi Sensu Lato and Relapsing Fever Borrelia in Feeding Ixodes Ticks and Rodents in Sarawak, Malaysia: New Geographical Records of Borrelia yangtzensis and Borrelia miyamotoi

Detection of Borrelia burgdorferi Sensu Lato and Relapsing Fever Borrelia in Feeding Ixodes Ticks and Rodents in Sarawak, Malaysia: New Geographical Records of Borrelia yangtzensis and Borrelia miyamotoi

Identification of Amblyomma Javanense and Detection of Tick-Borne Ehrlichia Spp. In Confiscated Malayan Pangolins

Borrelia miyamotoi DNA in a patient suspected of Lyme borreliosis

Contact Info

Product

Resources

About