BRAF‐mutated malignant melanoma with chondrosarcomatous differentiation in inguinal nodal metastasis

Abstract

We report the case of a young woman who developed metastatic melanoma in the inguinal nodal region, which acquired chondrosarcomatous differentiation and preserved the BRAF mutation found in the primary tumor. The patient was treated with a BRAF/MEK inhibitor combination therapy (dabrafenib/trametinib), which was demonstrated to be effective and well‐tolerated.

Primary Undifferentiated/Dedifferentiated Cutaneous Melanomas—A Review on Histological, Immunohistochemical, and Molecular Features with Emphasis on Prognosis and Treatment

“…Nevertheless, this expression is usually weaker than in osteosarcomas [ 40 ]. These tumors tend to occur on acral skin, but various other locations, such as the sun-exposed skin of the face, have been reported [ 41 , 42 , 43 ]. Local traumatism may trigger these lesions, as various authors have reported a history of trauma at the site of osteo-chondroid melanomas [ 42 ].…”