2011
DOI: 10.1111/j.1755-148x.2011.00837.x
|View full text |Cite
|
Sign up to set email alerts
|

BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the primary tumor site

Abstract: SUMMARY Oncogenic BRAF mutations are more frequent in cutaneous melanoma from sites with little or moderate sun-induced damage than from sites with severe cumulative solar ultraviolet (UV) damage. We studied cutaneous melanomas from geographic regions with different levels of ambient UV radiation to delineate the relative effects of cumulative UV damage, age and anatomic site on the frequency of BRAF mutations. We show that BRAF-mutated melanomas occur in a younger age group on skin without marked solar elasto… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

31
137
0
7

Year Published

2011
2011
2023
2023

Publication Types

Select...
6
1
1

Relationship

0
8

Authors

Journals

citations
Cited by 196 publications
(175 citation statements)
references
References 25 publications
31
137
0
7
Order By: Relevance
“…Further support for the association between ultraviolet exposure and TERT promoter mutations was apparent from an increased frequency of the mutations in tumours arising at the sites that are either intermittently or chronically exposed to sunlight compared with rarely exposed parts of the body 32 . Other features that supported the same proposition included association of the mutations in melanomas arising at the site of solar lentigines, the hyper pigmented lesions that are mostly seen in sun-damaged areas of skin 33 .…”
Section: Discussionmentioning
confidence: 89%
“…Further support for the association between ultraviolet exposure and TERT promoter mutations was apparent from an increased frequency of the mutations in tumours arising at the sites that are either intermittently or chronically exposed to sunlight compared with rarely exposed parts of the body 32 . Other features that supported the same proposition included association of the mutations in melanomas arising at the site of solar lentigines, the hyper pigmented lesions that are mostly seen in sun-damaged areas of skin 33 .…”
Section: Discussionmentioning
confidence: 89%
“…BRAF-mutant melanomas are associated with young age at diagnosis, intermittently sun-exposed sites such as the trunk, superficial spreading subtype, absence of solar elastosis, and presence of mitoses [17,60,63,64,93,144,155,228]. NRAS-mutant melanomas are associated with older age at diagnosis, but less associated with specific anatomic location, are more likely to be nodular subtype, and show increased Breslow thickness and presence of mitoses [60,63,64,86,139,228,231,234].…”
Section: Clinical Characteristics Of Tumor Subtypesmentioning
confidence: 99%
“…As BRAF V600E mutations occur early in mutagenesis and are associated with exposure to intermittent UVR exposure rather than chronic UVR exposure, 2,7,31 it is possible that early low-dose intermittent UVR exposure is sufficient to enable BRAF mutation after which other, at this point unknown, mutation drivers become the predominant mutagenic process in this subset of melanomas.…”
Section: Cutaneous Melanomas Lacking a Uvr Signaturementioning
confidence: 99%
“…6 Furthermore, melanomas arising in areas of intermittent UVR exposure, such as the trunk, back and abdomen, and those arising in sites of chronic UVR exposure, such as head and neck, have different associations with risk factors, histological appearances, and mutation profiles. 7,8 Melanomas from intermittently UVR-exposed sites tend to occur in younger patients, more commonly arise in pre-existing benign nevi, more often have superficial spreading histology and more often BRAF mutated, compared with melanomas arising in chronically exposed skin. 7 In contrast, the latter tend to occur in older people, are more commonly of lentigo maligna histological subtype and are less likely to carry BRAF mutation.…”
mentioning
confidence: 99%
See 1 more Smart Citation