<i>Bryophyllum pinnatum</i> in the treatment of restless legs syndrome: A case series documented with polysomnography

Manitius, Sigrid von; Flügel, Dominique; Steinlein, Bettina Gievers; Martin, Sebastian; Mandach, Ursula von; Simões‐Wüst, Ana Paula

doi:10.1002/ccr3.2144

Cited by 10 publications

(3 citation statements)

References 36 publications

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“…Seeds of Vigna radiata were used for this investigation. Four different concentrations (25,50,75, and 100 μg/mL) of SiNPs were prepared using distilled water. The seeds were surface sterilized using distilled water.…”

Section: Agricultural Applications Seed Germination Analysismentioning

confidence: 99%

Bio-fabrication of bio-inspired silica nanomaterials from Bryophyllum pinnatum leaf for agricultural applications

Periakaruppan

Sasivarnam

et al. 2022

Preprint

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Green chemistry approach was employed to synthesize Silica nanoparticles (SiNPs) using aqueous extract of Bryophyllum pinnatum leaf as capping agents. The physicochemical properties of formed nanoparticles were successfully completed through sophisticated characterization methods such as UV-Visible absorbance spectroscopy, Fourier Transform Infra-Red spectroscopy, X-Ray Diffraction, Scanning Electron Microscope, Energy Dispersive X-Ray, Zeta Potential Analysis and Thermo-Gravimetric Analysis. All the characterization results were indicating that the spherical morphology, amorphous nature with an average size of 24 nm of nanoparticles formed. FT-IR results highlighted the key bioactive compounds that could be responsible for capping and reduction to formation of SiNPs. As synthesized SiNPs shows excellent stability with negative zeta potential value − 32 mV. The biomolecules from B. pinnatum were successfully working for the formation of SiNPs with spherical shape. Moreover, to assess agricultural application of green synthesized SiNPs was carried out by seed germination assay on Vigna radiata. The seed germination assay confirms that the low concentration of SiNPs enhances the seed germination. Meanwhile, the higher concentration of the SiNPs inhibits the seed germination, shoot and root formation. SiNPs at optimum concentration could be used in the agriculture field as nano growth promoters.

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Section: Agricultural Applications Seed Germination Analysismentioning

confidence: 99%

Bio-fabrication of bio-inspired silica nanomaterials from Bryophyllum pinnatum leaf for agricultural applications

Periakaruppan

Sasivarnam

et al. 2022

Preprint

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“…In 2010, Bryophyllum preparations were already frequently used by anthroposophic physicians in Germany for the treatment of mental and behavioural disorders such as sleep disorders, anxiety, and depressive symptoms [2]. Since then, three prospective trials and one case series reported improved sleep quality during treatment with B. pinnatum (50% chewable tablets): during pregnancy [12], in cancer [13], associated with restless legs syndrome [14] and with nocturia [8]. Although little is known about possible mechanisms of action that would support its use in the treatment of mental and behavioural disorders, some results from animal models support a CNS depressant action, as well as sedative and anxiolytic effects [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

How Physicians and Nursing Staff Perceive Effectiveness and Tolerability of <i>Bryophyllum</i> Preparations: An Online Survey in an Anthroposophic Hospital

Huber,

Krüerke,

Simões-Wüst

2024

Complement Med Res

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Background: Bryophyllum preparations are widely used in anthroposophic medicine, most often for mental and behavioural disorders. Three prospective studies have revealed positive effects of Bryophyllum pinnatum on sleep quality, and various trials have shown very good tolerability. Results from animal models have indicated CNS depressant and anxiolytic effects. This survey was conducted at the hospital “Klinik Arlesheim”, in Switzerland, to find out how the physicians and the nursing staff perceive the effectiveness and the tolerability of the Bryophyllum preparations they most frequently use. Design: Internal, anonymous online survey of healthcare professionals (April 8th - May 31st 2022). The questionnaire comprised 105 multiple-choice questions. Answering the questions was taken as consent to participate in the survey. Participants and Methods: All physicians and nursing staff with a valid email address at the hospital “Klinik Arlesheim AG” were invited via email to participate in this REDCap survey. The data were analysed descriptively. Results: Out of 266 invited participants, 48 answered some and 36 answered all questions (response rate between 18.0% and 13.5%). The participants had long experience with Bryophyllum preparations and were comprised of approximately equal numbers of physicians and nursing staff. Various Bryophyllum preparations from the hospital´s own production and Wala Heilmittel GmbH (in both cases produced from the species B. daigremontianum), and from Weleda AG (species B. pinnatum) were used. The indications for which most participants had prescribed or administered Bryophyllum preparations “very frequently” were anxiety, sleep disorders, crisis situations in oncology, posttraumatic stress disorder, benzodiazepine dependence/withdrawal and depression. Improvements such as relief from restlessness, decreased anxiety, balance, easier falling asleep, better sleeping through, increased resilience, mood elevation, and less urge to move one’s legs were reported “frequently” or “very frequently”. Almost all participants agreed that Bryophyllum can be used to reduce the intake of synthetic sedatives or psychotropic drugs, but only approximately half believed that it could replace them. The majority of participants mentioned good tolerability of the various products, but a few reported occasional stomach or intestinal irritation, daytime fatigue, drowsiness, diarrhoea and nausea. Conclusion: Bryophyllum preparations are perceived as helpful in the treatment of various mental disorders, particularly anxiety, and generally well tolerated. Most of these preparations are used for indications that have not yet been clinically investigated.

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“…In Switzerland, its use during pregnancy to prevent preterm uterus contractions is well established [ 20 , 21 ], and uterus-relaxant properties have been proven at both the tissue [ 22 , 23 ] and cell level [ 24 , 25 ]. Some clinical studies have revealed its potential in the treatment of sleep disorders, be they during pregnancy [ 26 ] or associated with other diagnoses [ 27 , 28 ]. Its use in these indications corresponds well to the sedative, central nervous system depressant, and anxiolytic properties that have been shown in animal models, namely rats, mice [ 29 ], and zebra fish [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Bryophyllum pinnatum and Improvement of Nocturia and Sleep Quality in Women: A Multicentre, Nonrandomised Prospective Trial

Mirzayeva

Forst

Passweg

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Nocturia is a pathologic condition that significantly affects the quality of sleep. The aetiology of nocturia is multifactorial, and the evidence available on its management remains limited. Besides behavioural measures, validated pharmaceutical treatment options exist but are, however, associated with marked side effects. Prospective clinical studies with tablets prepared from the leaf press juice of the plant Bryophyllum pinnatum revealed a tendency towards reduction of micturition in patients with overactive bladder (OAB) and several improvements in sleep quality. These observations are in part supported by in vitro and in vivo data. In the present study, we investigated the effectiveness of Bryophyllum 50% chewable tablets in the treatment of nocturia and associated sleep disorders. Altogether, 49 women with idiopathic OAB and nocturia of ≥2 voids/night were treated with Bryophyllum 50% tablets for 3 weeks (350 mg chewable tablets, dosage 0-0-2-2 oral tablets; WELEDA AG, Arlesheim, Switzerland). Nocturia, voiding volumes at night (ml), quality of life, sleep quality, and daily sleepiness were assessed before and after treatment with a 3-day micturition diary, the International Consultation on Incontinence evaluating overactive bladder and related impact on quality of life (QoL) [ICIQ-OAB], the Pittsburgh Sleep Quality Index (PSQI), and the Epworth Sleepiness Scale (ESS), respectively. The age of the study population was 68.5 ± 11.6 y. After treatment, nocturia diminished from 3.2 ± 1.4 to 2.3 ± 1.3 ( P < 0.001 ) and the PSQI score decreased from 7.7 ± 3.7 to 6.6 ± 3.4 ( P = 0.004 ). Urgency, the ICIQ score, and the ESS lowered significantly, and the micturition volume showed a tendency to increase. No serious adverse drug reactions were reported, and compliance was good. The results show a beneficial effect on the nocturnal voids and sleep quality of women with OAB. Bryophyllum 50% tablets can be regarded as a well-tolerated alternative in the treatment of nocturia and broaden the repertoire of standard management.

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Bryophyllum pinnatum in the treatment of restless legs syndrome: A case series documented with polysomnography

Cited by 10 publications

References 36 publications

Bio-fabrication of bio-inspired silica nanomaterials from Bryophyllum pinnatum leaf for agricultural applications

Bio-fabrication of bio-inspired silica nanomaterials from Bryophyllum pinnatum leaf for agricultural applications

How Physicians and Nursing Staff Perceive Effectiveness and Tolerability of <i>Bryophyllum</i> Preparations: An Online Survey in an Anthroposophic Hospital

Bryophyllum pinnatum and Improvement of Nocturia and Sleep Quality in Women: A Multicentre, Nonrandomised Prospective Trial

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