<i>Burkholderia pseudomallei</i> in Environment of Adolescent Siblings with Melioidosis, Kerala, India, 2019

Bhaskaran, Praveena; Prasad, Vinitha; Gopinathan, Anusha; Shaw, Tushar; Sivadas, Suchitra; Jayakumar, Chandrasekhar; Chowdhury, Soumi; Dravid, Aparna; Mukhopadhyay, Chiranjay; Kumar, Anil

doi:10.3201/eid2806.211526

Cited by 7 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…B. pseudomallei possesses various virulence factors enabling its attachment and persistence in both phagocytic and nonphagocytic cells [3]. Interestingly, infection of the oropharyngeal lymphoid tissue has been suggested by previous reports of sore throat and tonsillitis in children with melioidosis [17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal melioidosis: a case report

Mohan,

Yeong,

Kumarasamy

et al. 2023

J Infect Dev Ctries

View full text Add to dashboard Cite

A 12-year-old boy was admitted after 11 days of fever and 2 days of nasal obstruction as well as swelling of a right cervical lymph node. Nasal endoscopy and computed tomography of the neck showed a nasopharyngeal mass occupying the entire nasopharynx, extending into the nasal cavity, and obliterating the fossa of Rosenmuller. Abdominal ultrasonography revealed a small solitary splenic abscess. Although a nasopharyngeal tumor or malignancy was initially considered, biopsy of the mass showed only suppurative granulomatous inflammation, and bacterial culture from the enlarged cervical lymph node yielded Burkholderia pseudomallei. The symptoms, nasopharyngeal mass, and cervical lymph node enlargement resolved with melioidosis-directed antibiotic therapy. Although rarely reported, the nasopharynx may be an important primary site of infection in melioidosis patients, especially in pediatric patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal melioidosis: a case report

Mohan,

Yeong,

Kumarasamy

et al. 2023

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…In addition, case reports of focal infections have shown that most patients have a good prognosis, and the examination indicators for these patients are quite different from the clinical manifestations of HLH[ 4 - 6 ]. Systemic infections are not complicated by MODS[ 2 ]. Therefore, the final progression of secondary HLH to B. pseudomallei sepsis contributes to patient mortality, and B. pseudomallei infection is mainly observed during the rainy season in tropical and subtropical regions.…”

Section: Discussionmentioning

confidence: 99%

“…However, granulocytopenia, which is common in areas where such cases have been reported, has been largely neglected by the research community. Combined with the clinical data on elevated ferritin levels, there is a need to examine the status of hemophagocytosis in deaths due to B. pseudomallei [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Fatal hemophagocytic lymphohistiocytosis-induced multiorgan dysfunction secondary to Burkholderia pseudomallei sepsis: A case report

Sui,

Wan,

Chen

et al. 2023

World J Clin Cases

View full text Add to dashboard Cite

Rehabilitation of lower limb amputation in developing countries is quite challenging. Though there are basic to highly advanced prostheses available in India, the set-up is still facing difficulties in developing countries. Prosthetic management is difficult due to lack of availability of prostheses and reduced affordability among low income populations. In this review we highlighted the lower limb amputation and prosthetic rehabilitation status in India. Currently, India is advancing well in the rehabilitation field, but further studies are required to provide more evidence and recommendation.

show abstract

“…Similar analysis from northern Vietnam linked three deaths in children from one family to likely ingestion of B. pseudomallei- contaminated water from a borehole on their property, which was damaged, presumptively allowing rainy season ingression of B. pseudomallei from soil [53 ▪ ]. Another environmental study was undertaken in India from the backyard of two siblings with melioidosis [54].…”

Section: Epidemiologymentioning

confidence: 96%

Melioidosis and Burkholderia pseudomallei: progress in epidemiology, diagnosis, treatment and vaccination

Currie

2022

Current Opinion in Infectious Diseases

View full text Add to dashboard Cite

Purpose of reviewMelioidosis and its causative bacterium Burkholderia pseudomallei are being found in unexpected locations and bacterial genotyping is providing new insights into global spread and where and how individuals are being infected. This review summarizes recent studies covering the epidemiology, diagnosis, treatment, and prevention of melioidosis. Recent findingsWhole-genome sequencing of B. pseudomallei from patients and environmental sampling is informing the phylogeography of B. pseudomallei at regional, continental, and global levels, while also defining the epidemiology for individual cases. The situation in Africa remains the most unresolved, while the evolving story of B. pseudomallei in the Americas may establish that B. pseudomallei is endemic in parts of southern USA. Guidelines for diagnosis and treatment of melioidosis are well established, and published mortality has decreased from 50% or higher to 10% or lower in some countries but access to laboratory and therapeutic resources are not available or are extremely limited in many melioidosis-endemic regions.

show abstract

Burkholderia pseudomallei in Environment of Adolescent Siblings with Melioidosis, Kerala, India, 2019

Cited by 7 publications

References 14 publications

Nasopharyngeal melioidosis: a case report

Nasopharyngeal melioidosis: a case report

Fatal hemophagocytic lymphohistiocytosis-induced multiorgan dysfunction secondary to Burkholderia pseudomallei sepsis: A case report

Melioidosis and Burkholderia pseudomallei: progress in epidemiology, diagnosis, treatment and vaccination

Contact Info

Product

Resources

About