<i>C. elegans</i>
            : Sequence to Biology

Hodgkin, Jonathan; Horvitz, H. Robert; Jasny, Barbara R.; Kimble, Judith

doi:10.1126/science.282.5396.2011

Cited by 41 publications

(21 citation statements)

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“…In addition, much is known about C. elegans biology. Its entire genome has been sequenced [35], its entire cellular development from zygote to adult has been described [80,81], and all 302 neurons of the hermaphrodite nervous system have been identified and their anatomical connections mapped by electron microscopy [91]. Because the worm is transparent, these neurons can be ablated to test their roles.…”

Section: Introductionmentioning

confidence: 99%

Touch sensitivity in Caenorhabditis elegans

Bounoutas

Chalfie

2007

Pflugers Arch - Eur J Physiol

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The nematode Caenorhabditis elegans was the first organism for which touch insensitive mutants were obtained. The study of the genes defective in these mutants has led to the identification of components of a mechanosensory complex needed for specific cells to sense gentle touch to the body. Multiple approaches using genetics, cell biology, biochemistry, and electrophysiology have characterized a channel complex, containing two DEG/ENaC pore-forming subunits and several other proteins, that transduces the touch response. Other mechanical responses, sensed by other cells using a variety of other components, are less well understood in C. elegans. Many of these other senses may use TRP channels, although DEG/ENaC channels have also been implicated.

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Section: Introductionmentioning

confidence: 99%

Touch sensitivity in Caenorhabditis elegans

Bounoutas

Chalfie

2007

Pflugers Arch - Eur J Physiol

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“…C. elegans is a self-fertilizing hermaphrodite that can also cross-fertilize, allowing for both homozygous and heterozygous offspring. The entire worm genome has been mapped and sequenced as well (Hodgkin et al 1998), allowing for the use of for-ward and reverse genetic techniques to elucidate the molecular mechanisms of habituation.…”

Section: Elegans As a Model Systemmentioning

confidence: 99%

Analyses of Habituation in Caenorhabditis elegans

Rose¹,

Rankin²

2001

Learn. Mem.

146

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Although the nonassociative form of learning, habituation, is often described as the simplest form of learning, remarkably little is known about the cellular processes underlying its behavioral expression. Here, we review research on habituation in the nematode Caenorhabditis elegans that addresses habituation at behavioral, neural circuit, and genetic levels. This work highlights the need to understand the dynamics of a behavior before attempting to determine its underlying mechanism. In many cases knowing the characteristics of a behavior can direct or guide a search for underlying cellular mechanisms. We have highlighted the importance of interstimulus interval (ISI) in both short-and long-term habituation and suggested that different cellular mechanisms might underlie habituation at different ISIs. Like other organisms, C. elegans shows both accumulation of habituation with repeated training blocks and long-term retention of spaced or distributed training, but not for massed training. Exposure to heat shock during the interblock intervals eliminates the long-term memory for habituation but not the accumulation of short-term habituation over blocks of training. Analyses using laser ablation of identified neurons, and of identified mutants have shown that there are multiple sites of plasticity for the response and that glutamate plays a role in long-term retention of habituation training.

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“…Free-living nematodes occupy the soil, seas, brackish water or fresh water, and some are regarded as "extremophiles" (Wharton 2003). One of them, Caenorhabditis elegans, was the first animal to have its entire genome sequenced (Hodgkin et al 1998). Some plant-parasitic species are economically important as pests of crops (Lee 2002).…”

Section: Introductionmentioning

confidence: 99%

Guide to the Parasites of Fishes of Canada Part V: Nematoda

Arai

Smith

2016

Zootaxa

605

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Keys are provided for the identification of the nematode species known to be parasites of Canadian fishes. The nematodes are described and illustrated, with a note of the site(s) they occupy in named fish host(s) and their geographical distribution. Parasite records are given by author and date, full details of which can be found in a bibliography of over 800 references. Diagnoses and keys for 22 Families, 47 genera and 88 species of nematodes are also given, together with a glossary of terms, a host-parasite list, and indices to both nematode parasites and hosts.

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C. elegans : Sequence to Biology

Cited by 41 publications

References 0 publications

Touch sensitivity in Caenorhabditis elegans

Touch sensitivity in Caenorhabditis elegans

Analyses of Habituation in Caenorhabditis elegans

Guide to the Parasites of Fishes of Canada Part V: Nematoda

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