<i>c‐Fos</i> expression in the spinal cord after acute sacral segmental nerve stimulation

Ishigooka, Manabu; Nakada, Teruhiro; Hashimoto, Tohru; Zermann, Dirk‐Henrik; Schmidt, Richard A.

doi:10.1002/nau.10041

Cited by 6 publications

(7 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Immunoreactivity to c‐ fos protein (a neuronal proto‐oncogene) was assessed at each spinal level in four control rats, six rats that underwent electrode implantation and 2 h of SNS and six rats that underwent electrode implantation alone. The authors demonstrated that SNS increased the number of c‐ fos ‐positive cells in the L5 to S3 segments, primarily in L6 and S1 (the segments which innervate the anorectum in the rat) when compared to both the control and electrode implantation only group and also that c‐ fos immunoreactivity was increased in all four sections of the spinal cord (dorsal commissure, lateral and medial dorsal horns and sacral parasympathetic nucleus) …”

Section: Resultsmentioning

confidence: 99%

A systematic review of sacral nerve stimulation mechanisms in the treatment of fecal incontinence and constipation

Carrington¹,

Evers

Grossi³

et al. 2014

Neurogastroenterology Motil

172

123

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

A systematic review of sacral nerve stimulation mechanisms in the treatment of fecal incontinence and constipation

Carrington¹,

Evers

Grossi³

et al. 2014

Neurogastroenterology Motil

172

123

View full text Add to dashboard Cite

show abstract

“…Therefore, SNS is typically used for treating diseases of the pelvic organs (36,48). However, more studies indicate the underlying central mechanism of SNS (8,15,18,20). Until now, no animal studies explored upper gastrointestinal effects of SNS.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, SNS increased the number of c-fospositive cells in the L 5 to S 3 spinal cord. Likewise, some studies indicated that neuromodulation of the sacral nerve might act on a central nerve system level (8,15,18,20). Therefore, some previous studies attempted to investigate the effects of SNS on upper gastrointestinal motor functions.…”

Section: Introductionmentioning

confidence: 99%

Sacral nerve stimulation increases gastric accommodation in rats: a spinal afferent and vagal efferent pathway

Liu

Li³

et al. 2020

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

Impaired gastric accommodation (GA) has been frequently reported in various gastrointestinal diseases. No standard treatment strategy is available for treating impaired GA. We explored the possible effect of sacral nerve stimulation (SNS) on GA and discovered a spinal afferent and vagal efferent mechanism in rats. Sprague-Dawley rats (450–500 g) with a chronically implanted gastric cannula and ECG electrodes were studied in a series of sessions to study: 1) the effects of SNS with different parameters on gastric tone, compliance, and accommodation using a barostat device; two sets of parameters were tested as follows: parameter 1) 5 Hz, 500 µs, 10 s on 90 s off; 90% motor threshold and parameter 2) same as parameter 1 but 25 Hz; 2) the involvement of spinal afferent pathway via detecting c-fos immunoreactive (IR) cells in the nucleus of the solitary tract (NTS) of the brain; 3) the involvement of vagal efferent activity via the spectral analysis of heart rate variability derived from the ECG; and 4) the nitrergic mechanism, Nω-nitro-l-arginine methyl ester (l-NAME), a nitric oxide synthase (NOS) inhibitor, was given before SNS at 5 Hz. Compared with sham-SNS: 1) SNS at 5 Hz inhibited gastric tone and increased gastric compliance and GA. No difference was noted between the stimulation frequencies of 5 and 25 Hz. 2) SNS increased the expression of c-fos in the NTS. 3) SNS increased cardiac vagal efferent activity and decreased the sympathovagal ratio. 4) l-NAME blocked the relaxation effect of SNS. In conclusion, SNS with certain parameters relaxes gastric fundus and improves gastric accommodation mediated via a spinal afferent and vagal efferent pathway. NEW & NOTEWORTHY Currently, there is no adequate medical therapy for impaired gastric accommodation, since medications that relax the fundus often impair antral peristalsis and thus further delay gastric emptying that is commonly seen in patients with functional dyspepsia or gastroparesis. The advantage of the potential sacral nerve stimulation therapy is that it improves gastric accommodation by enhancing vagal activity, and the enhanced vagal activity would lead to enhanced antral peristalsis rather than inhibiting it.

show abstract

“…Este mensajero se expresa después de la presencia de algún factor irritante químico sobre la vejiga o el tracto urinario bajo. Esto demuestra que la neuromodulación actúa también a nivel de mensajeros (18)(19)(20).…”

Section: Discussionunclassified

“…La neuromodulación provocada mediante estímulo transcutáneo o percutáneo del tibial, tiene efectos en la vejiga mediante la vía del plexo sacro, a través de estimulación aferente retrógrada (20).…”

Section: Discussionunclassified

Neuromodulación Periférica en El Tratamiento De La Incontinencia De Orina: Efecto De La Estimulación Transcutánea Del Nervio Tibial Posterior Sobre La Vejiga Hiperactiva

et al. 2008

Rev. chil. obstet. ginecol.

View full text Add to dashboard Cite

RESUMENObjetivo: Demostrar la efectividad de la neuromodulación con el sistema de estimulación transcutánea del nervio tibial posterior, en la inhibición de las contracciones no inhibidas del detrusor, en paciente con urgeincontinencia refractaria a tratamiento. Paciente: Se presenta un caso de incontinencia de orina mixta, con solución al componente de esfuerzo mediante TVT-Secur. El componente de urgencia, dado por vejiga hiperactiva, se trata mediante neuromodulación transcutánea del nervio tibial posterior, refractario al tratamiento medicamentoso y fisioterapia. Se demuestra objetivamente la acción de la neuromodulación, mediante la realización de una cistometría (urodinamia monocanal) durante la estimulación de nervio tibial (estímulos en modo continuo a 20 Hz y 200 milisegundos), comparada con la realizada sin estimulación. Resultados: Las contracciones no inhibidas del detrusor se inhibieron al realizar la neuromodulación con el sistema de estimulación transcutáneo del nervio tibial posterior, demostrado objetivamente por la desaparición de las contracciones durante la fase de llenado vesical. La capacidad cistométrica máxima, aumentó durante la neuromodulación y la sensación urgencia miccional disminuyó. Conclusión: La neuromodulación con el sistema de estimulación transcutánea del nervio tibial posterior, es efectiva en el tratamiento de la vejiga hiperactiva, lo que es posible de objetivar mediante la realización de una cistometría con urodinamia monocanal. Esta terapia ofrece una alternativa de tratamiento, con todas las características de mínima invasión.PALABRAS CLAVE: Incontinencia de orina, detrusor hiperactivo, vejiga hiperactiva, urge-incontinencia, urodinamia SUMMARYObjective: To demonstrate objectively the efficiency of the neuromodulation with the transcuteneous posterior tibial nerve stimulation in overactive bladder, in a patient with urge incontinence, refractory to traditional treatments. Patient: A case of urinary mixed incontinence is presented. The TVT-Secur was used for the stress urinary incontinence. The urge-incontinence due to overactive bladder was treated by transcutaneous tibial nerve neuromodulation when refractory appearing to the treatment with medicines and physiotherapy by thirty days. The action of the neuromodulation is demonstrated objectively by cystometry. Monochannel urodynamic equipment was used. The Biomed 2000 equipment was used for the transcutaneous neuromodulation, with stimuli in continuos way to 20 Hertz and 200 milliseconds. Results: The transcutaneous tibial 209 REV CHIL OBSTET GINECOL 2008; 73(3): 209 -213

show abstract

c‐Fos expression in the spinal cord after acute sacral segmental nerve stimulation

Abstract: SNS alone caused a near maximal response in c-Fos expression such that adding LUT irritation did not cause a linear increase in c-Fos. Subsequent LUT irritation could not induce additional expression of c-Fos within the spinal cord.

Cited by 6 publications

References 30 publications

A systematic review of sacral nerve stimulation mechanisms in the treatment of fecal incontinence and constipation

A systematic review of sacral nerve stimulation mechanisms in the treatment of fecal incontinence and constipation

Sacral nerve stimulation increases gastric accommodation in rats: a spinal afferent and vagal efferent pathway

Neuromodulación Periférica en El Tratamiento De La Incontinencia De Orina: Efecto De La Estimulación Transcutánea Del Nervio Tibial Posterior Sobre La Vejiga Hiperactiva

Contact Info

Product

Resources

About