2020
DOI: 10.1101/2020.09.09.289637
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Caenorhabditis elegans: a model to study the anthelmintic effects of polyphenolic compounds on the fertility of parasitic gastrointestinal nematodes?

Abstract: We set up a Caenorhabditis elegans model to extrapolate anthelmintic (AH) effects of commercial polyphenols to related gastrointestinal zoonotic species. We compared the practical convenience of S liquid to solid agar Nematode grown medium in daily reproduction patterns and total brood size. Solid agar resulted a highly effective, reproducibly medium, in a less costly and rapid time manner. A minimum of three replications per monomer concentration are suggested to get a robust statistical analysis. Flavonoids … Show more

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“…Te anthelmintic activity of the extracts of C. nioroense (Figures 5 and 6) may be due to the presence of phytochemicals such as alkaloids, saponins, tannins, favonoids, and glycosides. Tis is because the aforementioned secondary metabolites in the extracts have been reported to possess anthelmintic activity [46][47][48][49]. Te mode of action of some anthelmintics like imidazothiazoles, derquantel, and piperazine, which are all alkaloids, is to cause paralysis of worms, such that they can be expelled in the faeces of humans and animals [1,14].…”
Section: In Vitro Anthelminthic Activity Te Ethanol and Petroleum Eth...mentioning
confidence: 99%
“…Te anthelmintic activity of the extracts of C. nioroense (Figures 5 and 6) may be due to the presence of phytochemicals such as alkaloids, saponins, tannins, favonoids, and glycosides. Tis is because the aforementioned secondary metabolites in the extracts have been reported to possess anthelmintic activity [46][47][48][49]. Te mode of action of some anthelmintics like imidazothiazoles, derquantel, and piperazine, which are all alkaloids, is to cause paralysis of worms, such that they can be expelled in the faeces of humans and animals [1,14].…”
Section: In Vitro Anthelminthic Activity Te Ethanol and Petroleum Eth...mentioning
confidence: 99%