<i>Candida albicans</i>
            overgrowth disrupts the gut microbiota in mice bearing oral cancer

Wang, Xu; Wu, Shuangshaung; Li, Linman; Yan, Zhimin

doi:10.1080/21501203.2023.2256761

Cited by 8 publications

(2 citation statements)

References 43 publications

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“…Firmicutes and Bacteroidetes are two dominant phyla that together comprise 90% of the total gut microbiota. The F/B ratio is recognized as an important index of gut microbiota health [19] and is widely accepted as having an important influence in maintaining normal intestinal homeostasis. Increased or decreased F/B ratio is regarded as dysbiotic.…”

Section: Gut Microbiome Of Lc Aa Psoriasis Vitiligomentioning

confidence: 99%

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

W. Chambers

2024

JNNS

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The dermatological manifestations of Long Covid (LC) have languished in the shadows of chronic fatigue and brain fog. Yet they are all linked by gut dysbiosis and the cytokine triad of TNF-α, IL-1β, and IL-6. The gut microbiome common not only to LC, psoriasis, AA, and vitiligo but also to neurodegenerative disease has been recently described. This gut microbiome induces an altered tryptophan metabolism linked to autoimmune disease. SARS CoV2, Mycobacteria, and many intestinal parasites protectively upregulate IFN-γ (less Covid in BCG and in subSaharan Africa), triggering the characteristic altered tryptophan metabolism and curtailing synthesis of serotonin and melatonin. Chronic inflammation due to persistent spike protein S exhausts IFN-γ and leads to gut dysbiosis and autoimmune risk. Butyrate immunomodulates IFN-γ and TGF-β, which counterbalance each other (reciprocal relationship). Low IFN-γ (LC) translates to high TGF-β (organ fibrosis). This review suggests that an etiologic prebiotic (d-mannose)/probiotic (lactobacilli, bifidobacteria)/postbiotic (butyrate) approach to autoimmune skin disease that improves intestinal barrier integrity and that suppresses the triad of TNF-α, IL-6, and IL-1β may enhance or even eliminate the traditional immunotherapy of targeted monoclonal antibodies, Janus kinase inhibitors, and steroids. Health benefits of this approach extend well beyond suppression of autoimmune skin disease. Societal benefits include relief to those most affected - women (LC), especially of color (AA, psoriasis, vitiligo).

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Section: Gut Microbiome Of Lc Aa Psoriasis Vitiligomentioning

confidence: 99%

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

W. Chambers

2024

JNNS

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show abstract

“…Gut Microbiome of LC, AA, Psoriasis, Vitiligo Firmicutes and Bacteroidetes are two dominant phyla that together comprise 90% of the total gut microbiota. The F/B ratio is recognized as an important index of gut microbiota health 19 and is widely accepted as having an important influence in maintaining normal intestinal homeostasis. Increased or decreased F/B ratio is regarded as dysbiotic.…”

Section: Introductionmentioning

confidence: 99%

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

Chambers,

Chambers

2023

Preprint

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The dermatological manifestations of Long Covid (LC) have languished in the shadows of chronic fatigue and brain fog. Yet they are all linked by gut dysbiosis and the cytokine triad of TNF-α, IL-1β, and IL-6. The gut microbiome common not only to LC, psoriasis, AA, and vitiligo but also to neurodegenerative disease has been recently described. This gut microbiome induces an altered tryptophan metabolism linked to autoimmune disease. SARS CoV2 invades enterochromaffin cells rich in ACE2 receptors and curtails absorption of the essential amino acid tryptophan and subsequent synthesis of serotonin and melatonin. This review suggests that an etiologic prebiotic (d-mannose)/probiotic (lactobacilli, bifidobacteria)/postbiotic (butyrate) approach to autoimmune skin disease that improves intestinal barrier integrity and that suppresses the triad of TNF-α, IL-6, and IL-1β may enhance or even eliminate the traditional immunotherapy of targeted monoclonal antibodies, Janus kinase inhibitors, and steroids. Health benefits of this approach extend well beyond suppression of autoimmune skin disease.

show abstract